Is it about Arachidonic acid and Cb1 receptor and anandamide? ( HAIRLOSS, PFS, IMMUNE SYSTEM, PTSD)

[Helen]

PFS could be an imbalances of arachidonic acid. and CB1 receptor. and phospholipase.



people need to test their FFAs and supplement and see all their symptoms go away.


some need to get rid of sibo, to stop activation of phospholipase.


Some folks got psoriasis. in PFS. arachidonic acid gets rid of it. in some cases.

arachidonic acid is your immune system.


arachidonic acid suppresses prolactin release and increases dopamine.


arachidonic acid suppresses gaba release.





ESTROGEN increases arachidonic acid synthesis and cannabinoids. and opiods. ( anandamide) as I wrote many times.


EMOTIONS are cannabinoids and opiods. estrogen provides emotions thru these things


CB1 receptor controls CORTISOL and LH release. CB1 receptor control prolactin release. and gaba.


Finasteride stops hairloss just by making you deficient in arachidonic acid.


but it can never regrow temples. since you need arachidonic acid to actually regrow stuff

arachidonic acid turns into PGE2 and PGD2, PGD2 is what causes hairloss


and PGE2 is what grows hair.( by the way this is why castor oil works , since it activates this receptor)


but PGE2 is made with GLUTATHIONE.. so if you are missing glutathione. you will be losing hair. since all your arachidonic acid will be turning into PGD2.

unless you get deficient totally in arachidonic acid. ( which is what finasteride does.)

they you stop losing hair with very mediocre regrowth. which eventually wil; not even work, as you get totally deficient in arachidonic acid.. but get totally screwed with immune system emotions. etc regulation of hormones.


This is why raw meat dieters carnivore people all have terrible bad bad hair. since most of those people have very low levels of glutathione.

and they go on carnivore diet, since they feel better on it. but as they replenish arachidonic acid, they will be balding. but feeling better


look at sverige guy, look at baker, look at any carnivores , raw meaters, ALL bald. and will be bald.



Some people get pyroluria in PFS, what is pyroluria. pyroluria causes zinc and b6 deficiency, which causes deficency of arachidonic acid.

so some folks already had problems with this @MCurtone before PFS and thus stress caused similar symptoms.

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study



So we need to look into Cb1 receptors anandamide and arachidonic acid. and different cases .

SIBO for instance can activate phospholipase too much and flood the blood with arachidonic acid. as an example.

Also is it possible that finasteride upregulates those receptors too much like CB1? in some cases and then you get too much archidonic acid



I would be nice if people tested their fatty acids in blood

 

[Helen]

@tanedout for instance if you overload yourself with vitamin A. then your bile will be inhibited and you will be deficient in fatty acids.

this is why this vitamin A depletion thing especially for accutane people makes sense.

they eat zero vitamin A, but tons of arachidonic acid. on that diet.

 

[Helen]

As we saw in Melcangi study , there were no pregnenolone in CFS of finasteride people.

pregnenolone is antagonist of Cb1 receptor. as I wrote before.

 

[tanedout]

@tanedout for instance if you overload yourself with vitamin A. then your bile will be inhibited and you will be deficient in fatty acids.

this is why this vitamin A depletion thing especially for accutane people makes sense.

they eat zero vitamin A, but tons of arachidonic acid. on that diet.

Sounds like eating loads of eggs would increase it (although I guess then you get too much vit A/retinol), but overall it sounds like it’s pro inflammatory

arachidonic acid | Health Topics | NutritionFacts.org

 

[Helen]

@Orion

by the way, thyroid hormones deplete vitamin A stores. within 3 weeks. since it increases the production of retinoic acid. to supply ceruloplamin

obviously vitamin A is not a toxin.

but most of ray peat forum ate tons of it, along with liver ( COPPER)) and of course got toxic) when ray peat told them that it only should be taken with THYROID.

 

[Ingeno]

Somehow this theory sounds pretty logical and familiar, wondering if we ever could reach a balance where temple regrowth is possible.

 

[Helen]

Somehow this theory sounds pretty logical and familiar, wondering if we ever could reach a balance where temple regrowth is possible.

did you see that swiss temple dude regrow his temples like crazy, by blocking PGD2 and enhancing PGE2.

A loss recovered: My Progress

 

[RebelWithACause]

Finasteride lowers bile and androsterone (R-Andro)/DHT increases it right?

Maybe to undo the damage from lack of bile you need to push the body the opposite way with something like androsterone. Increase bile, feed the body the fatty acids it missed out on (years for some) and get back to normal.

But then what about the people who crashed after one pill? Are they all g6pd deficient? I don't get it. Since you will not be deficient in archidonic acid after one pill I would guess.

 

[Walker]

Finasteride lowers bile and androsterone (R-Andro)/DHT increases it right?

Maybe to undo the damage from lack of bile you need to push the body the opposite way with something like androsterone. Increase bile, feed the body the fatty acids it missed out on (years for some) and get back to normal.

But then what about the people who crashed after one pill? Are they all g6pd deficient? I don't get it. Since you will not be deficient in archidonic acid after one pill I would guess.

Androsterone definitely increases bile, plus the downstream DHT increases your overall 5AR production. I gained the most during my recovery during the four cycles I did that included Androsterone (Super R-Andro Rx).

TUDCA also increases bile flow from what I've read. Could be a good combo together, or used separately.

 

[Ingeno]

did you see that swiss temple dude regrow his temples like crazy, by blocking PGD2 and enhancing PGE2.

A loss recovered: My Progress

Yes, I have seen the story. He did have some sides if I remember correctly. Not strange with all the stuff he was doing. But the question remains if regrowth is possible on its own, without external topicals and shitt.

 

[TubZy]

Yes, I have seen the story. He did have some sides if I remember correctly. Not strange with all the stuff he was doing. But the question remains if regrowth is possible on its own, without external topicals and shitt.

He also couldn't stand the side of effects of dut without being in keto. He had been a keto person for like almost a decade. If he eats carbs he feels like shit.

 

[Nina]

@Orion

by the way, thyroid hormones deplete vitamin A stores. within 3 weeks. since it increases the production of retinoic acid. to supply ceruloplamin

obviously vitamin A is not a toxin.

but most of ray peat forum ate tons of it, along with liver ( COPPER)) and of course got toxic) when ray peat told them that it only should be taken with THYROID.

So if ceruloplamin rises in slow metabolism (by increasing it from outside through supplements), you waste more potassium, metabolism goes even lower and eventually ACTH tanks and copper becomes biounavailable (low k = low ceruloplasmin)

 

[MCurtone]

@Helen So the goal is to increase Arachidonic Acid? How would one go about doing that exactly?

I plan on continuing this raw meat diet but doing what I can to increase glutathione.
Also about to add TUDCA and Betaine HCL with pepsin to help start digesting better. Maybe this will increase my Arachidonic acid.

 

[Helen]

@Helen So the goal is to increase Arachidonic Acid? How would one go about doing that exactly?

I plan on continuing this raw meat diet but doing what I can to increase glutathione.
Also about to add TUDCA and Betaine HCL with pepsin to help start digesting better. Maybe this will increase my Arachidonic acid.

I think we need to look into this further , what if Cb1 receptor overexpression is primary problem.

if I were you since you mentioned that you had PFS before PFS.

I would test your arachidonic acid in blood and also linoiec and pyroles.

you see if you have pyroluria ( which is usually becasue of some metal toxicity )

then you cant even make arachidonic acid. since linoiec cant be converted into arachidonic.

and thus you could me missing, endrophns, cannabinoids, and opiiods. which are what your body deals with stress with.

 

[Helen]

@MCurtone meat diet like carnivore, usually is high in arachidonic acid. and zinc. so this is why you feel better on it.

 

[bruschi11]

I’m feeling way better post fast with lots of bone broth. Just normalizing type stuff. Makes sense. I had pyroluria too.

Also I have some testing I will post on my log very shortly today. Probably best form of testing out there for you @Helen - Called Nutreval it has so much stuff on it. Including fatty acids, aminos etc.

 

[bruschi11]

I have more than enough Linoleic acid. I have low arichidonic acid. So yes there seems to be a certain problem there in conversion.

 

[Helen]

I have more than enough Linoleic acid. I have low arichidonic acid. So yes there seems to be a certain problem there in conversion.

yes and linoleic acid causes symptoms, you have pyroluria.


if you have heavy metals like mercury. or lead or arsenic, it will cause pyroluria.

 

[Helen]

@bruschi11 if you ever decide to go with chelation. here is the good one for you. Emeramide | CAS#351994-94-0 | chelator | MedKoo

 

[bruschi11]

@bruschi11 if you ever decide to go with chelation. here is the good one for you. Emeramide | CAS#351994-94-0 | chelator | MedKoo

Good stuff. When I'm ready and I'll get there for sure. Mercury is crazy man- been going at it a little bit with Rife. Chem depression sucks, but its not as bad as it used to be so system is making strides in handling it.

I'm posting my labs now on my log. You will love this test.