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RU-486 (mifepristone) sources
RU-486 (mifepristone) sources
RU / "Mifepristone Challenge" Log
- Thread starter jinstewart
- Start date
jinstewart
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@5 alpha
Thanks for the kind words, but honestly it was @Boris ' idea, I just bought the stuff and ran it. The tests were just what we should be doing (if we can afford and it's feasible for individuals ofc.) I myself will never find 'the answer' but I CAN at least provide useful things to people like Helen, who probably will. No guts involved really, it was looking safe enough from the studies posted, although Minime's cautionary tale was well worth bearing in mind.
Your total T, free T and DHT were more or less in the normal range prior to starting your trial. About half way through your trial your total T, free T and DHT increased by not all that much but enough to put your free T and total T slightly over the top of your labs reference range. Your LH and FSH were on the low side before your trial and remained on the lowish side half way through your trial. So really nothing significant with changes to your total T, free T, DHT, LH and FSH during trial. However, your progesterone and cortisol which were already on the high side increased significantly during your trial. Before trying to chime in on any possible conclusions that can be made thus far I first wanted to make sure that I am correct with everything I stated in my summary.
- Yes that's about right. I've put the running tests in the OP but it's a lot to follow ofc. Also Oestradiol went MENTAL.
What is your current plan on the post labs? How are you feeling now?
- I think I'll run the post-bloods next week or early the following week. Feeling like improvements are maybe dropping back just a little tiny bit. But had a HUGELY stressful end to last week and same yesterday. No question I'm coping better with that, sleep has improved a lot and 'world immersion' is a little better and 'wellbeing' has improved a few points. Sexually maybe a small decline even, but that's only the last week ish. I'm kinda still reeling from work recently, it's been that stressful, so could be that. Been off the masturbation since Thursday, don't feel like it at all.
Current plan is wait a couple of weeks. I've ordered enough alibaba powder to run a savage amount, and the 'feeling' about it is to run this way higher for a little longer. So long as that delivery actually arrives I'll be ready after the post-bloods. I'll see what the thinking is. 1g/day for 7 days vaguely I think.
honestly man this is fucking awesome
- Thanks!
Tbh it's good being considered a viable candidate for experiments here and I can log them sensibly and if I hit something useful to us we have bloods to refer to. All the quick antibiotic/random med recoveries, the creeping tribulus/gut/CDnuts ones... We (Helen and crew) must be able to figure this out.
So yes, unless anyone wants me trialling anything else the above is my plan. @Helen if you approve also of that interval between post-bloods and starting again then I'll proceed.
EDIT - post-bloods are due to be taken next Friday, so results should be with us <2 weeks after that. Let's see what we did. 13g of RU is ready for deliver today, cost me all of $200. I'll post the source at some point, when I have something of an idea it's legit. Western Union for that one though, no PayPal. :/
Thanks for the kind words, but honestly it was @Boris ' idea, I just bought the stuff and ran it. The tests were just what we should be doing (if we can afford and it's feasible for individuals ofc.) I myself will never find 'the answer' but I CAN at least provide useful things to people like Helen, who probably will. No guts involved really, it was looking safe enough from the studies posted, although Minime's cautionary tale was well worth bearing in mind.
Your total T, free T and DHT were more or less in the normal range prior to starting your trial. About half way through your trial your total T, free T and DHT increased by not all that much but enough to put your free T and total T slightly over the top of your labs reference range. Your LH and FSH were on the low side before your trial and remained on the lowish side half way through your trial. So really nothing significant with changes to your total T, free T, DHT, LH and FSH during trial. However, your progesterone and cortisol which were already on the high side increased significantly during your trial. Before trying to chime in on any possible conclusions that can be made thus far I first wanted to make sure that I am correct with everything I stated in my summary.
- Yes that's about right. I've put the running tests in the OP but it's a lot to follow ofc. Also Oestradiol went MENTAL.
What is your current plan on the post labs? How are you feeling now?
- I think I'll run the post-bloods next week or early the following week. Feeling like improvements are maybe dropping back just a little tiny bit. But had a HUGELY stressful end to last week and same yesterday. No question I'm coping better with that, sleep has improved a lot and 'world immersion' is a little better and 'wellbeing' has improved a few points. Sexually maybe a small decline even, but that's only the last week ish. I'm kinda still reeling from work recently, it's been that stressful, so could be that. Been off the masturbation since Thursday, don't feel like it at all.
Current plan is wait a couple of weeks. I've ordered enough alibaba powder to run a savage amount, and the 'feeling' about it is to run this way higher for a little longer. So long as that delivery actually arrives I'll be ready after the post-bloods. I'll see what the thinking is. 1g/day for 7 days vaguely I think.
honestly man this is fucking awesome
- Thanks!
Tbh it's good being considered a viable candidate for experiments here and I can log them sensibly and if I hit something useful to us we have bloods to refer to. All the quick antibiotic/random med recoveries, the creeping tribulus/gut/CDnuts ones... We (Helen and crew) must be able to figure this out.So yes, unless anyone wants me trialling anything else the above is my plan. @Helen if you approve also of that interval between post-bloods and starting again then I'll proceed.
EDIT - post-bloods are due to be taken next Friday, so results should be with us <2 weeks after that. Let's see what we did.
13g of RU is ready for deliver today, cost me all of $200. I'll post the source at some point, when I have something of an idea it's legit. Western Union for that one though, no PayPal. :/
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@5 alpha
Thanks for the kind words, but honestly it was @Boris ' idea, I just bought the stuff and ran it. The tests were just what we should be doing (if we can afford and it's feasible for individuals ofc.) I myself will never find 'the answer' but I CAN at least provide useful things to people like Helen, who probably will. No guts involved really, it was looking safe enough from the studies posted, although Minime's cautionary tale was well worth bearing in mind.
Your total T, free T and DHT were more or less in the normal range prior to starting your trial. About half way through your trial your total T, free T and DHT increased by not all that much but enough to put your free T and total T slightly over the top of your labs reference range. Your LH and FSH were on the low side before your trial and remained on the lowish side half way through your trial. So really nothing significant with changes to your total T, free T, DHT, LH and FSH during trial. However, your progesterone and cortisol which were already on the high side increased significantly during your trial. Before trying to chime in on any possible conclusions that can be made thus far I first wanted to make sure that I am correct with everything I stated in my summary.
- Yes that's about right. I've put the running tests in the OP but it's a lot to follow ofc. Also Oestradiol went MENTAL.
What is your current plan on the post labs? How are you feeling now?
- I think I'll run the post-bloods next week or early the following week. Feeling like improvements are maybe dropping back just a little tiny bit. But had a HUGELY stressful end to last week and same yesterday. No question I'm coping better with that, sleep has improved a lot and 'world immersion' is a little better and 'wellbeing' has improved a few points. Sexually maybe a small decline even, but that's only the last week ish. I'm kinda still reeling from work recently, it's been that stressful, so could be that. Been off the masturbation since Thursday, don't feel like it at all.
Current plan is wait a couple of weeks. I've ordered enough alibaba powder to run a savage amount, and the 'feeling' about it is to run this way higher for a little longer. So long as that delivery actually arrives I'll be ready after the post-bloods. I'll see what the thinking is. 1g/day for 7 days vaguely I think.
honestly man this is fucking awesome
- Thanks!
So yes, unless anyone wants me trialling anything else the above is my plan. @Helen if you approve also of that interval between post-bloods and starting again then I'll proceed.
EDIT - post-bloods are due to be taken next Friday, so results should be with us <2 weeks after that. Let's see what we did.
awesome man
Please keep us updated
I have been seriously considering the possibility of running a similar experiment while trying to block prog production. It's just extra risky doing two things that I have never done before at the same time. High dose RU combined with trying to inhibit Prog production. Also there does not seem like there are 2 many options to inhibit Prog production. I tried asking Helen about it in another thread but I am wondering if all the extra prog your body produced while taking the high dose RU prevented or limited the RU's ability to have its desired effect on the prog receptors. Of course I am just guessing and have no back ground in any of this. It does feel like an educated guess though seeing that it is possible for pregenant woman who take RU while also taking high dose prog to not have an abortion. In other words enough prog made it to the receptors to prevent the abortion for some woman also taking high doses of prog while taking the RU>
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it is a big difference between feeding extra huge progesterone levels. from oustide to over take Ru, and just taking RU and body is trying to adjust progesterone production.
Still blocking progesterone receptor will upregulate it, of course blocking receptor and production at the same time, will upregulate it more.
interesting....
I suppose that's good assuming the goal for a particular person is to up-regulate. Before I had my first successful RU trial my Prog was low which I guess insinuates that at that time my prog receptors were already up-regulated which complicates things as to why it even worked for me. Maybe some people's norm requires them to have up-regulated receptors who knows. I guess it's guess work and god for bid if up-regulating is not what a particular person wants to have happen and you are now taking taking RU combined with blocking prog production to force additional up-regulation you are asking for trouble.
Risky business. Maybe the smartest thing to do is first take the drug that inhibits prog production alone to see how I react and than later combine it with RU or just go all out the first time and it is what it is.
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If you solely think your issue is prog related and not cortisol and/or both that could be beneficial. However maybe you should try Ella which primarily focuses on blocking progesterone only then you can compare what you felt better on RU vs Ella. Then you can know Cortisol vs prog vs AR etc
Thanks man
I don't know if you seen from the private chat with joekool that it looked like you were a part of I had no idea that you were Tubz. It's good to hear from you
I will have to consider doing that. Maybe I could just order some Ella and run that for now to get to the bottom of what you are saying to do which also gives me more time to sit back and put more thought into this whole inhibiting 3β-hydroxysteroid dehydrogenase idea.
I translated to english in my browser. It says "this drug is sent to the regions of the russian federation and the CIS only by prepayment"
I attached a screen shot. So I suppose we are SOL in the US. It does look like a trust worthy source though.
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jinstewart
Well-Known Member
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Thanks Helen! I'm also now the proud owner of >10g Mifepristone powder which I got from China, delivered for $180. However I'll only find out if that's RU or baby formula next time I run this. Which I'll likely do shortly after the "post-bloods" come in. If we're able to source something branded (and Russian) though I feel that'd be better.
EDIT - Source for the powder was also this place, although their prior min order was 1g. Discrete shipping, very polite, takes a good couple of weeks to come though:
[Hot Item] High Quality Mifepristone CAS 84371-65-3 for Medical Abortion
EDIT - Source for the powder was also this place, although their prior min order was 1g. Discrete shipping, very polite, takes a good couple of weeks to come though:
[Hot Item] High Quality Mifepristone CAS 84371-65-3 for Medical Abortion
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did you do the transaction using alibaba or did you just purchase it directly from the Wuhan Shu Ou Technology Co., Ltd. website? I am working on figuring out the whole albaba thing. They can hook you up with so many different companies that sell Mifepristone for research lab purposes. It's actually pretty cool. So far i have one seller responding to me telling me they will do 15g for $188. This is awesome...
Maybe if I get my hands on some as well I can see if I can have it tested some where in the US
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@jinstewart did you get bloods drawn yet post RU?
jinstewart
Well-Known Member
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- 189
Hi - yes I sent them a message through the site there, rest was done over email (confirmed quote, Western Union-ed the money from a branch in town - just told the branch I was buying some electronics samples,) got a tracking number and watched it for a couple of weeks. Came stealthily enough.
Hi - no that'll be Friday morning. When they're in I'm tempted to run again. I'll weigh the powder out into capsules on micro scales and set myself up.
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I found a Chines supplier on Alibaba who is willing to do 15g of mifepristone for $90.00 USD. I sent them the money using western union. no fee! and the $90.00 covers shipping costs from the company. I hope I did not get scammed! will let everyone know.
15g=15000 Milligrams so this is a lot of experiments. Next, I will start researching how to have it tested by a lab in the US.
jstewart are you still planning on running an even higher than 800MG dose per day? I am going to start "writing out" the possible ways I am going to run this. With talk of the Cortisol receptors in the other thread being to blame and seeing that your Cortisol levels shot through the roof just like your Prog levels did while on RU that's kinda of confirmation that the mifepristone is blocking Cortisol receptors as well. I actually did not know mifepristone blocks Cortisol receptors until Boris and Helen mentioned it. Now that I know this I am kinda thinking of new possible ways to go about this.
15g=15000 Milligrams so this is a lot of experiments. Next, I will start researching how to have it tested by a lab in the US.
jstewart are you still planning on running an even higher than 800MG dose per day? I am going to start "writing out" the possible ways I am going to run this. With talk of the Cortisol receptors in the other thread being to blame and seeing that your Cortisol levels shot through the roof just like your Prog levels did while on RU that's kinda of confirmation that the mifepristone is blocking Cortisol receptors as well. I actually did not know mifepristone blocks Cortisol receptors until Boris and Helen mentioned it. Now that I know this I am kinda thinking of new possible ways to go about this.
jinstewart
Well-Known Member
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- 189
Ooh nice!
I am, yes. Once the "post bloods" are in I'll run 1-1.2g/day for 7 days or possibly longer. I think 1.2g was the maximum dose anyone in the human trials ran. I think the most I could do ofc would be 1.2g/day for 10 days given the dust left in the packet etc.
Maybe this time I'll make the BIGGEST knock out of it I can and do the full 10 days @ 1.2g. Not totally sure yet.
What you thinking of doing? I'm aware there was a lady who took a smaller dose for months and it equalled her adrenals nicely. I can't find that at the moment though.
EDIT - that's this one, if I'm reading it right: Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency
jinstewart
Well-Known Member
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- 189
Tell you what, if you want to fiddle with the latter idea I'll run the "big hit" idea for 10 days. I didn't really feel DRAMATICALLY better on the RU, but maybe a little bit. Then again it was only a short short run. This'll be double the length and 50% stronger dose too.
I'm tempted to start Monday even, before the bloods come back, but I'd probably just better wait for the results and see.
@Helen do you have any thoughts on the upcoming?
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