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It seems that PAS and PSSD share many of the same symptoms. I've seen on several forums, that many blame the 5HT1A receptor for PSSD. As the auto-receptor version of 5HT1A becomes desensitised due to SSRI use, which persists after stopping the SSRI. As a result there is an excess of 5HT1A...

I was just wanting to know if Gbol had made any changes or released any more info regarding post accutane syndrome (PAS) in relation to sexual sides etc. (not hairloss). I appreciate Gbol has written extensively, and is constantly being pestered by people on the forum, so I know he has no...

Can people please state whether their post accutane sexual sides are accompanied by any other significant side effects such as: 1. Depression 2. Anhedonia (get noticeably less pleasure from normally pleasurable activities) 3. Loss of motivation/ drive 4. Loss of interest in socialising, social...

I'm postulating that one possible theory of accutane induced problems is due to accutane increasing D2R expression in regions of the brain such as the striatum. This may persist after treatment and could interfere with normal reward processing in the VTA, due to hyperactivity of the striatum...

Does anyone have any links to any papers showing that accutane or a metabolite of accutane such as atra increases progesterone? I have found one paper in rats but I can't find anything else. And can anyone provide evidence or a theory of how accutane could increase progesterone? Thanks

Sorry to keep posting new threads, but I'm very interested in finding anyone with PAS particularly those with sexual side effects who has tried RU486 or ELLA? Several theories of PAS induced sexual dysfunction would likely be treated by RU486, given its effect on androgen receptor expression...

Hi guys, I'm not sharing this to promote another website etc. for personal gain, I've donated myself. I simply think the success and support of a project like this, will help us all. This is one of the only organisation which is taking these conditions seriously. If people suffering from these...

Hi there, I'm currently investigating a few causes of PAS and how we could treat them. I thought it might be useful if people published or shared any blood results they have. To make this more useful, if you post any blood results you have, could you also post your major symptoms such as sexual...

Just out of interest, has anyone tried the DHT + estrogen route. I know its only a temporary fix but surely it would be very useful to know whether it actually works. As surely if people tried this route and it didn't work or do anything, then all the other protocols may need to be rethought...

Could anyone clarify the link between progesterone, progestins etc. in relation to accutane. Gbols theories make complete sense in relation to PFS but I'm confused about how it links to accutane? Would be greatly appreciated!!!

I'm really starting to think that dopamine underlies much of the sexual side effects we feel. Particularly with Accutane induced sexual dysfunction. Also possible with Fin as its been shown to damage the nucleus accumbens I think its possible that our dopamine receptors have been down regulated...

Are there any post accutane sufferers currently experimenting with any of the protocols on this forum such as Gbols protocols? Have they noticed any improvement or found any protocols to be ineffective (not worth trying)? Would be useful to know, I'm looking to jump on a protocol or get some...

I am currently researching the causes of accutane induced sexual dysfunction. I have seen on many forums, people say that accutane/isotretinoin is a 5 alpha reductase inhibitor. However I am struggling to find research papers which support this claim. Could people please link any research...

Hi there, I just wanted to make a thread and see if anyone with post-accutane syndrome, specifically with side effects relating to sexual dysfunction (loss of libido, loss of morning wood, lack of sexual arousal/response, less pleasure from orgasm) has found anything in regards to protocols...