I never thought humans were significant lol. Humanity looks more like how bacteria operate, they take over stuff overwhelm resources with reproduction replication, etc. I don't think humans are special at all. It's religion yes that feeds the belief we are magical beings. But of course always backed by violence because their belief is nonsense so people who believe in it get upset and violent (narcissistic injury) when they can't see they are just organisms and you don't agree with the magical thinking. Reason why christians, muslims, etc. they killed millions of people.
Most people's lives are in a way useless in the big picture. Even people who did a lot for the world so called it's nothing in the eyes of the system that humans come out of and are dominated by which is biological, replication, domination over environment and resources.
It simply doesn't care about 1 person. 1 Person is like 1 cell in an organism or a bacteria... it's nothing. And then add on top of that you can even add the theory of million planets. Even on Earth most of us don't matter in the long term big picture. Even some billionaires don't. Or whoever you think is "important".
Human nature is just like a bacteria and an animal. But we have comforts and ability to step aside from it to an extent but the system is still working underneath... 24/7, always. Even after you go to dust the machine of human nature does not care. It's all built. Incl. our emotions, anger, sadness, etc. to reproduce survive. It's not built for you to see true reality either. It's just a way for you succeed in the basic biological need. Even people helping each other often is. That's why it's useless endeavor.
But it is depressing a lot. Because you really get that feeling how insignificant we are.. Like I said I think that is the main reason why people don't want to look at that reality and just find comfort in nonsense like religion..