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Some people felt better on this. @joekool @Ocguy
As I mentioned, for slow oxidizers high calcium people. I think gaba overexpression might be causing a problem.
other gaba a inhibitors are clarithromycin and other microlides.
Clarithromycin in GABA-related Hypersomnolence: A Randomized, Crossover Trial
Flumazenil effective in refractory hypersomnolence
You see they use flumazenil to achieve same gaba a inhibition as with those antibiotics.
obviously this is not a cure, but I am just mentioning the possible mechanism how it helps to feel better.
Also jack17 by inhibiting 5AR with dut. could lower both allo and 3 adiol and thus lower gaba. action. and feel good.
Gaba is complicated as it inhibits and raises prolactin.
Some say that copper in the pituitary blocks gaba and causes increased prolactin release
and in second variant in CNS gaba lowers dopamine, and increases prolactin by that mechanism.
So gaba at the pituitary lowers prolactin. Effect of GABA agonists and modulators on prolactin release - ScienceDirect
and at CNS increases prolactin.
Now TEI says that slow oxidizers are toxic in copper in the brain. thus it blocks GABA at the pituitary. so then you have gaba, which raises prolactin at CNS and no gaba which inhibits prolactin release at the pituitary. so end effects prolactin release. which then retains calcium.
So this could be the case also.
So for slow oxidizers, it is either overexpressed gaba receptor as it is, or imbalance of gabas between pituitary and CNS which is caused by copper in the brain.
1) overexpressed GABA receptor would cause high prolactin. and this retains calcium non stop. which then increases progesterone, inhibits cortisol and estrogen. and histamine, which obivously kills opiods, canabinoids, and endorphins.
2) copper in the brain, will increases prolactin by blocking gaba , this will increase Prolactin, retains calcium. and increases progesterone, and decreases estrogen,
and inhibit histamine. kills opiods, canabinoids, and endorphins.
Variant number 2 is what promoted by TEI and ARL. for slow oxidizers.
variant number 1 is overexpressed gaba. I like this variant, but it is hard to believe in any receptor imbalance. since receptors adjust in days. to any situation. To me the variant number 2 is organic and is more likely. of course overexpressed gaba does not help this situation at all.
As I mentioned, for slow oxidizers high calcium people. I think gaba overexpression might be causing a problem.
other gaba a inhibitors are clarithromycin and other microlides.
Clarithromycin in GABA-related Hypersomnolence: A Randomized, Crossover Trial
Flumazenil effective in refractory hypersomnolence
You see they use flumazenil to achieve same gaba a inhibition as with those antibiotics.
obviously this is not a cure, but I am just mentioning the possible mechanism how it helps to feel better.
Also jack17 by inhibiting 5AR with dut. could lower both allo and 3 adiol and thus lower gaba. action. and feel good.
Gaba is complicated as it inhibits and raises prolactin.
Some say that copper in the pituitary blocks gaba and causes increased prolactin release
and in second variant in CNS gaba lowers dopamine, and increases prolactin by that mechanism.
So gaba at the pituitary lowers prolactin. Effect of GABA agonists and modulators on prolactin release - ScienceDirect
and at CNS increases prolactin.
Now TEI says that slow oxidizers are toxic in copper in the brain. thus it blocks GABA at the pituitary. so then you have gaba, which raises prolactin at CNS and no gaba which inhibits prolactin release at the pituitary. so end effects prolactin release. which then retains calcium.
So this could be the case also.
So for slow oxidizers, it is either overexpressed gaba receptor as it is, or imbalance of gabas between pituitary and CNS which is caused by copper in the brain.
1) overexpressed GABA receptor would cause high prolactin. and this retains calcium non stop. which then increases progesterone, inhibits cortisol and estrogen. and histamine, which obivously kills opiods, canabinoids, and endorphins.
2) copper in the brain, will increases prolactin by blocking gaba , this will increase Prolactin, retains calcium. and increases progesterone, and decreases estrogen,
and inhibit histamine. kills opiods, canabinoids, and endorphins.
Variant number 2 is what promoted by TEI and ARL. for slow oxidizers.
variant number 1 is overexpressed gaba. I like this variant, but it is hard to believe in any receptor imbalance. since receptors adjust in days. to any situation. To me the variant number 2 is organic and is more likely. of course overexpressed gaba does not help this situation at all.
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