PSSD Proposed Solution

[TeslaFan]

For PSSD only.

In short: Acetazolamide + Copper + Potassium + Magnesium + some Calcium.

It will NOT work with just Acetazolamide!

Acetazolamide increases CO2 in blood, and reduces PH of the same. This fools the body into believing metabolism is higher than it is because there is more byproduct of metabolism (CO2 and acidity in blood). This will reduce serotonin release in the blood, which is important part of recovery: to reset serotonin receptors, then lower blood levels, and break serotonin dominance. Body will respond by trying to lower metabolism and trying to alkalize the blood. Notable things during Acetazolamide:

1. Body will pull potassium from the cell into blood (to slow down metabolism by lowering cell’s sensitivity to thyroid AND to alkalize blood as potassium is alkalizing mineral). Kidneys will then waste potassium out. If you don’t take potassium, you’ll develop hypokalemia, Sodium will become dominant, and you will develop volume expansion.
Potassium chloride is good, and cream of tartar with orange juice.

2. For almost the same reasons, body will pull Magnesium from cells into blood (to have less Magnesium-ATP complexes in the cell, and to alkalize blood). If you don’t take Magnesium, you will not oppose Sodium, may become diabetic, depressed, and host of other problems because Magnesium is a master mineral.
Magnesium Chloride is good.

3. Body will raise Calcium in blood via PTH, also to alkalize blood. This can hurt your teeth and/or give you headaches. A glass of milk a day should keep PTH in check.

4. Acetazolamide is a Sulfur compound, and it will strongly oppose Copper! If you don’t supplement with Copper your MAO-A will drop, Serotonin will go up, and you will be back to square one. Also, you may develop gray hair, and anxiety.
Copper-Niacin, Copper Sebacate, or Copper Glycinate are good.

Cofactors are the KEY.

Thanks to [mention]gbolduev[/mention] for many details.

Also, according to some theories, large dozes of Thiamine (also a Sulfur compound and a carbonic anhydrase inhibitor) may be able to replace Acetazolamide, but I haven’t tried this. Same cofactors would apply.

 

[Jaxx]

This is a really surprizing solution/ direction. Do you have thoughts on amounts and frequency etc? Also, how does this relate to high progesterone?

 

[barbaar]

I'm also interested in what dosages, and for what duration we should take all this stuff. Or is that up to us to figure out? Acetazolamide sounds like it's pretty powerful, and not without its own side effects. If this truly could be a cure, that's a risk I'd be willing to take though.

I was also wondering if MSM, another sulfur compound, could also be related to this mechanism. Someone on pssdforum got complete remission of his symptoms for a week while taking that iirc, it didn't stick though and didn't work anymore after that according to him.

 

[TubZy]

Just out of curiosity how come this would be for PSSD only? Is it due to the calcium?

 

[Helen]

This is a dangerous topic. I did not post this as a cure yet.I posted this as the first thing I will be trying tonight. I will try things and test them. People are too quick to jump to the conclusions. Be patient

 

[barbaar]

This is a dangerous topic. I did not post this as a cure yet.I posted this as the first thing I will be trying tonight. I will try things and test them. People are too quick to jump to the conclusions. Be patient

Fingers crossed gbol. You're amazing for doing this!

 

[Shadow]

please, I know that we need to fix this crap, but listen to [mention]gbolduev[/mention], dont rush things!

 

[TeslaFan]

This is a really surprizing solution/ direction. Do you have thoughts on amounts and frequency etc? Also, how does this relate to high progesterone?

I did it for a week. Single 250 mg pill each day. My progesterone was normal. I never took Fin. That's why I am saying this is for PSSD, and I would add, at a later stage of PSSD when your sexual function is back to normal but you still have alkalosis and volume expansion.

If you recently took SSRI, maybe longer time is needed. I took SSRI over 8 years ago, and wanted to fix the remaining alkalosis.

 

[TeslaFan]

I'm also interested in what dosages, and for what duration we should take all this stuff. Or is that up to us to figure out? Acetazolamide sounds like it's pretty powerful, and not without its own side effects. If this truly could be a cure, that's a risk I'd be willing to take though.

I was also wondering if MSM, another sulfur compound, could also be related to this mechanism. Someone on pssdforum got complete remission of his symptoms for a week while taking that iirc, it didn't stick though and didn't work anymore after that according to him.

Not sure, but I remember when I took MSM once I got extra gray hair. It wastes Copper.

 

[TeslaFan]

Just out of curiosity how come this would be for PSSD only? Is it due to the calcium?

No, Calcium is just to keep PTH in check. I say only for PSSD because I cannot say it's for PFS, never took it. Also, my progesterone was normal, as I never played with it.

 

[TeslaFan]

This is a dangerous topic. I did not post this as a cure yet.I posted this as the first thing I will be trying tonight. I will try things and test them. People are too quick to jump to the conclusions. Be patient

I tested and shared my experience. Thank you for your significant contribution. This is mostly a summary of your ideas, which worked for me. Cheers! And, please, when you have a chance, answer my private PM. Thank you!

 

[Jaxx]

Just out of curiosity how come this would be for PSSD only? Is it due to the calcium?

No, Calcium is just to keep PTH in check. I say only for PSSD because I cannot say it's for PFS, never took it. Also, my progesterone was normal, as I never played with it.

The general idea is that ssri’s raise progresterone levels, which seems to be backed with many pssd blood tests. Do i understand right that your sexual function was already fully healed when trying this protocol?
Looking forward to whatever comes out of this.

 

[Helen]

This is a dangerous topic. I did not post this as a cure yet.I posted this as the first thing I will be trying tonight. I will try things and test them. People are too quick to jump to the conclusions. Be patient

I tested and shared my experience. Thank you for your significant contribution. This is mostly a summary of your ideas, which worked for me. Cheers! And, please, when you have a chance, answer my private PM. Thank you!

Nice, that it helped you. I thought you were following my yesterdays post in Gbold theory thread. I posted there that I will try this regimen tonight. I forgot I posted this regimen before. Good for you. I actually took finasteride again. a week ago. And now I am in PFS. And today is the first day I am applying this regimen to myself. I think it will work.

So happy, that it worked for you. Alkalosis is bad news and is the thing that is stopping the natural recovery


I will answer your PM tomorrow. Huge brain fog today after the fin crash.

 

[ruprmurdoch]

I am asking, one more time (sorry for being obtrusive) what levels of progesterone in blood are considered as high in your opinion?

 

[Helen]

on the high end of the range or above

 

[Anonymous]

I am asking, one more time (sorry for being obtrusive) what levels of progesterone in blood are considered as high in your opinion?

I'd say mine are quite good example :roll:

 

[wuf]

For PSSD only.

In short: Acetazolamide + Copper + Potassium + Magnesium + some Calcium.

It will NOT work with just Acetazolamide!

Acetazolamide increases CO2 in blood, and reduces PH of the same. This fools the body into believing metabolism is higher than it is because there is more byproduct of metabolism (CO2 and acidity in blood). This will reduce serotonin release in the blood, which is important part of recovery: to reset serotonin receptors, then lower blood levels, and break serotonin dominance. Body will respond by trying to lower metabolism and trying to alkalize the blood. Notable things during Acetazolamide:

1. Body will pull potassium from the cell into blood (to slow down metabolism by lowering cell’s sensitivity to thyroid AND to alkalize blood as potassium is alkalizing mineral). Kidneys will then waste potassium out. If you don’t take potassium, you’ll develop hypokalemia, Sodium will become dominant, and you will develop volume expansion.
Potassium chloride is good, and cream of tartar with orange juice.

2. For almost the same reasons, body will pull Magnesium from cells into blood (to have less Magnesium-ATP complexes in the cell, and to alkalize blood). If you don’t take Magnesium, you will not oppose Sodium, may become diabetic, depressed, and host of other problems because Magnesium is a master mineral.
Magnesium Chloride is good.

3. Body will raise Calcium in blood via PTH, also to alkalize blood. This can hurt your teeth and/or give you headaches. A glass of milk a day should keep PTH in check.

4. Acetazolamide is a Sulfur compound, and it will strongly oppose Copper! If you don’t supplement with Copper your MAO-A will drop, Serotonin will go up, and you will be back to square one. Also, you may develop gray hair, and anxiety.
Copper-Niacin, Copper Sebacate, or Copper Glycinate are good.

Cofactors are the KEY.

Thanks to @gbolduev for many details.

Also, according to some theories, large dozes of Thiamine (also a Sulfur compound and a carbonic anhydrase inhibitor) may be able to replace Acetazolamide, but I haven’t tried this. Same cofactors would apply.

Are you saying that with this protocol you restored your sexual sides?

 

[TeslaFan]

Just out of curiosity how come this would be for PSSD only? Is it due to the calcium?

No, Calcium is just to keep PTH in check. I say only for PSSD because I cannot say it's for PFS, never took it. Also, my progesterone was normal, as I never played with it.

The general idea is that ssri’s raise progresterone levels, which seems to be backed with many pssd blood tests. Do i understand right that your sexual function was already fully healed when trying this protocol?
Looking forward to whatever comes out of this.

There is some connection between SSRI and Progesterone. For example, it is well known that SSRI increases allopregnanolone, which is a derivative of dihydroprogesterone, which is one derivative of progesterone. Not sure if there is more direct correlation. Maybe there is.

Correct, sexual function was already pretty good at this point, so I could describe my situation as later-stage PSSD, which is basically alkalosis. It's been almost a decade now since I last touched SSRI.

 

[TeslaFan]

This is a dangerous topic. I did not post this as a cure yet.I posted this as the first thing I will be trying tonight. I will try things and test them. People are too quick to jump to the conclusions. Be patient

I tested and shared my experience. Thank you for your significant contribution. This is mostly a summary of your ideas, which worked for me. Cheers! And, please, when you have a chance, answer my private PM. Thank you!

Nice, that it helped you. I thought you were following my yesterdays post in Gbold theory thread. I posted there that I will try this regimen tonight. I forgot I posted this regimen before. Good for you. I actually took finasteride again. a week ago. And now I am in PFS. And today is the first day I am applying this regimen to myself. I think it will work.

So happy, that it worked for you. Alkalosis is bad news and is the thing that is stopping the natural recovery


I will answer your PM tomorrow. Huge brain fog today after the fin crash.

Oh, I was following your posts for a long time, when you first appeared at RP forum.You mentioned acetazolamide there, after discussing it with a friend of yours, an anesthesiologists, as a solution for alkalosis. And you mentioned your concern of potassium problems. This is where it got me interested. Then, on this forum, you also mentioned something that caught my attention: try copper + magnesium + potassium FIRST, then add zinc + manganese AFTER. I think this order is crucial. I even re-quoted that on this forum, half-jokingly saying it's a cure itself.

Please take your time to deal with this Fin testing. My PM questions are not super urgent, I just wanted to make sure you didn't forget it entirely. I am curious about some biochemistry. PFS people are priority.

 

[Shadow]

No, Calcium is just to keep PTH in check. I say only for PSSD because I cannot say it's for PFS, never took it. Also, my progesterone was normal, as I never played with it.

The general idea is that ssri’s raise progresterone levels, which seems to be backed with many pssd blood tests. Do i understand right that your sexual function was already fully healed when trying this protocol?
Looking forward to whatever comes out of this.

There is some connection between SSRI and Progesterone. For example, it is well known that SSRI increases allopregnanolone, which is a derivative of dihydroprogesterone, which is one derivative of progesterone. Not sure if there is more direct correlation. Maybe there is.

Correct, sexual function was already pretty good at this point, so I could describe my situation as later-stage PSSD, which is basically alkalosis. It's been almost a decade now since I last touched SSRI.

To be more precise about Allo increase, SSRIs make 3a-HSD convert more 5α-Dihydroprogesterone(endogenous progestin) to Allopregnenolone.

Maybe it works like this:
3a-HSD start to synthesize much more Allopregnenolone from 5α-Dihydroprogesterone.
As a consequence more 5α-Dihydroprogesterone needs to be synthesized from Progesterone, leading to an increase in both 5aDHP and P levels.
For some unknown reason or by stopping the drug, 3a-HSD stop synthesizing Allo like crazy.
The Allo levels drop abruptly leading to symptoms related to GABA A receptors.
There are too much 5α-Dihydroprogesterone(progestin) laying around and it starts fucking with things like finasteride.