Yet Another interesting brain nootropic - Emoxypine Succinate

[Helen]

@joekool this is why in some of my anavar trials, I had people have totally zero POIS while on anavar. but when they came off. POIS increased and they were complaining that anavar made it worse

Since anavar upregulated AR density.


this is why if you take testosterone you increase DHT, this is what you have been doing. And there is zero low test state on 100mg a week, or 20mg a week)) you will be always higher than the baseline even on 10mg a week
And the minute testosterone finds NADPH floating around, it binds it and makes DHT.

so you keep spiking your DHT )) this is why you felt like total shit at first, and over time, body gets used to extra DHT by downregulating AR density in DHT sensitive tissues like brain and prostate. and you have less adrenaline activation, since DHT activates adrenaline and aldosterone

 

[Helen]

As far as going on finasteride, one dose and then taking time off.

Please go on finasteride and check

1) insulin level
2) NADPH levels
3) DHT levels


Finasteride increases INSULIN level when you take it Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats
same exactly like testosterone does)) and effects minerals the same way also.

Why finasteride increases insulin? since it binds NADPH. and insulin MAKES NADPH )) same as testosterone also binds NADPH ( this is why you do low dose test)) since otherwise you crash with ANEMIA))) since test will bind all your NADPH and insulin wont be able to make new one.

and say hello to hemolytic anemia LOL

so when you take one dosage of finasteride you increase insulin

Then the action of fin goes way, but insulin stays higher than before. and you have NADPH produced in higher amounts

and this creates DHT spikes. this is like taking nasal insulin, which we know helps some PFS cases. and those people who tried it , felt effects of almost full recovery in DAYs, not years))

 

[vicecaz]

Regarding insulin, a lot of people with PAS already had issue with insulin before going on accutane

Insulin spike, after eating food with a high glycemic index/sugar ( white bread/pasta, whatever ) for example, increases androgen and thus sebaceous gland especially in people with insulin resistance
Insulin resistance in severe acne vulgaris

It was my case at least. I was just uninformed at 16 to realize it

It could be a mechanism of Hair loss - Male pattern baldness too

 

[Helen]

Regarding insulin, a lot of people with PAS already had issue with insulin before going on accutane

Insulin spike, after eating food with a high glycemic index/sugar ( white bread/pasta, whatever ) for example, increases androgen and thus sebaceous gland especially in people with insulin resistance
Insulin resistance in severe acne vulgaris

It was my case at least. I was just uninformed at 16 to realize it

It could be a mechanism of Hair loss - Male pattern baldness too

insulin resistance is low thyroid.

body does not want to keep inserting sugar into the cell, since it does not get burnt

 

[Blugrass]

@Helen could milk thistle be used as a substitute to sulforaphane in the experiment you did? Or do they have different effects on androgens and androgen receptors

I'm looking back in my journal, I noticed that sometimes I have good erections a few days after taking Milk Thistle in a single dose. But could be a coincidence.
I should mention that I don't feel good while on milk thistle.

 

[Blugrass]

@joekool there is a case of PFS where people feel better upregulating androgen receptor.

but in those cases the problem is with GABA not androgen receptor.

GABA does not lets progesterone convert further into its metabolites

and progesterone is blocking AR. this is why in those people they would feel better if they upregulate AR receptors( their receptors are upregulated already as it is ) . or they kill progesterone with ella ( etc)

But that should not be done. Since the minute you take care of your GABA problem, you would be totally bald as it happened to Minimi)) since androgen receptor is already upregulated to fight high progesterone.


These people have high DHEA. since 3 beta hsd is not working. since 3 beta hsd wil make more progesterone.


This is why these people benefit from raising acetylcholine. which lowers their gaba and calcium. and they would feel cured on it.


and that is why some of them feel cured on DHEA. since DHEA blocks GABA and progesterone pours into allopregnenolone.

The level of progesterone falls and AR receptor= free.

DHEA is high in my labs, I measured twice in blood, and once in saliva, it's over the range every time. I also measured progrestrone once and it was in high end. Hmmm interesting

 

[Helen]

@Helen could milk thistle be used as a substitute to sulforaphane in the experiment you did? Or do they have different effects on androgens and androgen receptors

I'm looking back in my journal, I noticed that sometimes I have good erections a few days after taking Milk Thistle in a single dose. But could be a coincidence.
I should mention that I don't feel good while on milk thistle.

sulphoraphane is dangerous for the wrong bodychemistry.

if milk thistle is working for you , you do milk thistle

 

[ruprmurdoch]

Sulbutiamine increases NADPH which increases 5AR/. it increases acetylcholine which then upregulates D1 receptor.

b6 increases dopamine production. and increases histamine production.


B1 vitamin or sulbuthiamine which is also b1 or benfo also works., increases NADPH and increases 5AR.

this is why I used it after fin crash. right away along with potassium.



Also hormones regulate neurotransmitters. not the opposite.


Estrogen increases copper in the cell, which converts dopamine into noradrenaline for instance.

Testosterone increases iron , which increases dopamine production.


When you sleep you have no activation of sympathetic nervous system. less activation, that is why you have more erections.

and when you wake up, your adrenaline system is activated fully and you have shrinkage, since sugar metabolism is closed down since it would produce NADPH)) and increase DHT.



If the body is trying to fight high DHT. or too sensitive DHT, it closes down production of NADPH, ( b1 is the main player in this , since B1 increases transkelotase)


this is why in PFS in half of the cases we have totally shut down INSULIN. since insulin increases NADPH and g6pd which produces NADPH, and NADPH is the substrate for 5AR


This is why when you take FIN, fin binds NADPH. and the body increases INSULIN to produce more of NADPH. to fight finasteride binding to NADPH.

then when you quit Finasteride. YOUR receptors are super sensitive, and in half of the cases, the body just simply SHUTS down all SUGAR metabolism not to produce NADPH< this is what the crash is..

this is why we see super low insulin in half of the cases in PFS


Since insulin is shut down. then body has to use only fats for energy , thus you have your turtling, shrinkage and all other stuff. since your dopamine is basically excessively converts into noradrenaline and adrenaline to get to fatty acids.

this why during any stress, going to the bathroom, waking up , you will have too little dopamine OVERALL.



This is why I used B1( benfo) in my case, since B1 along with potassium , increased my 5AR and kept it steady, and did not allow the body to shut down 5AR function.

Potassium pushed insulin production, and B1 pushed NADPH production, which stopped 5AR from shutting down, and this forced receptors to downregulate


In most people. basically, if AR is overexpressed, body just shuts down insulin and NADPH production.

Without NADPH, you cant protect your red blood cells, and you get anemia.( this is what crash is) and your folic acid goes to zero. along with b12

Now as folic acid goes to zero, since to make tetrafolate you need NADPH. but remember body closed down production of NADPH.

Since there is zero tetrafolate , body loses histidine into the urine. And since histidine is not there, your b6 cant work. since b6 converts histidine into histamine.

NADPH is very important. I gain a bit of kg more while on antibiotics last year, and started taking chromium(g6pd probably work on this) + benfotiamine(active b1 ), I really have much more energy than last 8 months. Guys remember a lot of antibiotics decrease NADPH, so vitamin b1 and probably chromium. And like helen wrote above :

,,Without NADPH, you cant protect your red blood cells, and you get anemia.( this is what crash is) and your folic acid goes to zero. along with b12

Now as folic acid goes to zero, since to make tetrafolate you need NADPH. but remember body closed down production of NADPH.

Since there is zero tetrafolate , body loses histidine into the urine. And since histidine is not there, your b6 cant work. since b6 converts histidine into histamine."

 

[Ingeno]

Would regular thiamine hcl be sufficient as well instead of benfothiamine?