Hmmm, well it looks like the body can generate phosphatidylcholine from phosphatidylserine so I guess that's not surprising.
Why did I feel so good on Finasteride?
- Thread starter Continuous Heal
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Aflac94
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Hopefully not a coincidence, I'm gonna have give it a try my sleep sucks. What brand did you get?
NOW brand, off Amazon, soy version
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@Continuous Heal this is why you felt good on finasteride.
Elevated levels of inhibitory neurosteroids, namely allopregnanolone, can produce paradoxical effects, such as negative mood, anxiety, irritability, and aggression.[39][40][41][42] This appears to be because these neurosteroids, like other positive allosteric modulators of the GABAA receptor such as the benzodiazepines, barbiturates, and ethanol,[34][42] possess biphasic, U-shaped actions – moderate levels (in the range of 1.5–2 nM/L total alloprogesterone, which are approximately equivalent to luteal phase levels) inhibit the activity of the GABAA receptor, while lower and higher concentrations facilitate the activity of the receptor.[40][41]
Elevated levels of inhibitory neurosteroids, namely allopregnanolone, can produce paradoxical effects, such as negative mood, anxiety, irritability, and aggression.[39][40][41][42] This appears to be because these neurosteroids, like other positive allosteric modulators of the GABAA receptor such as the benzodiazepines, barbiturates, and ethanol,[34][42] possess biphasic, U-shaped actions – moderate levels (in the range of 1.5–2 nM/L total alloprogesterone, which are approximately equivalent to luteal phase levels) inhibit the activity of the GABAA receptor, while lower and higher concentrations facilitate the activity of the receptor.[40][41]
Continuous Heal
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So having low allo made me feel great (as if it were high allo)... At some point my stress levels in life were elevated, and this resulted in a rise in allo into the moderate range?, and hence the negative mood and anxiety during the crash? So I now I want to be back into high allo in order to feel like I used to, without the nerve damage?
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What makes more sense now is that all these people who are still on fin or took fin in the past reversed there sides with high doses of zinc. This is while they were on fin, but they also said there hair shedded more again.
Since fin is a progestin and zinc is used to increase progesterone this would make sense. The body doesn't need to make progesterone anymore since you are taking finasteride which is a progestin. The body can't lower progesterone so it gets rid of zinc (and magnesium too probably) which is why it would cause estrogen to rise (zinc lowers estrogen). Both zinc and magnesium put potassium back into the cell. That is probably why adding zinc back in while on fin alleviates many of the side effects because you are necessarily forcing it.
What I always wondered why some people get sides and others don't. Maybe if zinc, magnesium and copper stores were full when coming off fin, the HPTA wouldn't become imbalanced and it would prevent PFS from happening. Just a thought though since I have seen countless logs of people on fin who take zinc to reverse the sides of it.
Since fin is a progestin and zinc is used to increase progesterone this would make sense. The body doesn't need to make progesterone anymore since you are taking finasteride which is a progestin. The body can't lower progesterone so it gets rid of zinc (and magnesium too probably) which is why it would cause estrogen to rise (zinc lowers estrogen). Both zinc and magnesium put potassium back into the cell. That is probably why adding zinc back in while on fin alleviates many of the side effects because you are necessarily forcing it.
What I always wondered why some people get sides and others don't. Maybe if zinc, magnesium and copper stores were full when coming off fin, the HPTA wouldn't become imbalanced and it would prevent PFS from happening. Just a thought though since I have seen countless logs of people on fin who take zinc to reverse the sides of it.
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@TubZy Shouldn't high doses of Zinc be listed in this thread then? Summary of PFS, PSSD & Post Accutane Experimental Treatments (as of 12/16)
Aflac94
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Is this stuff still working or was it a one time help?
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There is a difference between using zinc while on fin versus PFS. I was just using zinc as an example in this case, I'm not saying it is for PFS. High dose zinc with maybe potassium could be an option for PFS but there is no evidence behind it to consider it a treatment at least for now, if you try it, let us know/log it. Zinc will lower cortisol and the potassium will bring down the progesterone. I can't handle zinc alone but when I tried zinc and potassium I felt way better on it, haven't experimented with it much though, I do way better with copper.
Just saying that when you are taking fin, you are essentially turning off your body's natural progesterone. This was shown in studies, people on finasteride have lower prog levels which means fin is acting as a progestin since body senses that progesterone (fin) is already in circulation. The difference is that fin as a progestin can't convert to cortisol or neurosteroids etc. like natural progesterone does and this makes the entire cascade get screwed up. This causes down regulation of enzymes and receptors in order for the body to compensate. So when you take away the progestin (fin) your enzymes and receptors are still screwed up, that is why by just increasing progesterone by say, just taking zinc, it doesn't work and you could actually feel worse. So things can work while taking fin perfectly fine but cannot with PFS.
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Kind of. I slept from 4am to 10am today instead of my usual 11pm to 3am. So I'm getting about 2 hours extra.
@TubZy I am taking finasteride again at this very moment, I am on the fifth day, I am an accutane sufferer, I took the first time finasteride for 28 days after seeing the accutane recoveries using finasteride and felt an improvement of about 15% on my libido after stopping , do you think I should take zinc along with finasteride now that I am taking it again then?
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Possibly but I'll be honest I don't know with post accutane whether you want to feel worse or not while taking fin in order to feel better when coming off for it to work..however I do know zinc is a cofactor in creating retinoic acid which is what accutane is derived from
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@TubZy hmm, the first time I took finasteride I did not feel anything, now I do not feel anything, just my hair that is falling a little again, same the first time I took it, how many mg of zinc would you recommend taking? 30?
I hope this can help me, I will take until the day I stop with finasteride again, I must take for 25 days I think
problem that I have some doubts about the 2 pharmacies of handling that has in my city, here is very small, sometimes I think they are false manipulations because I do not feel practically anything, do you think I should add magnesium too or vitamin E?
@gbolduev Could you please give us your opinion on this too?
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Yeah I would use at least 30 or more, in the logs people mentioned 30 or higher too to feel the effects.
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I also wanted to mention that there was I believe two PFS users (not from here) that went back on finasteride for a short time period and felt better. Then they got off again and felt better in baseline. I'm not suggesting this at all, just using as an example.
For the record, I don't believe they were taking anything else like zinc or anything like that, that I remember, so how you responded your first time seems to make sense.