Downregulating D2R expression with dopamine agonists - Any thoughts?

[Flynn]

I'm postulating that one possible theory of accutane induced problems is due to accutane increasing D2R expression in regions of the brain such as the striatum. This may persist after treatment and could interfere with normal reward processing in the VTA, due to hyperactivity of the striatum.

I'm thinking of trying to downregulate D2R expression using a dopamine agonist such as bromocriptine. A study showed signficant decreases in D2R expression when bromocriptine was mixed with clozapine.

does anyone have any experience with either of these drug types?

 

[Orion]

I have tried lisuride, it definitely produces good mood, and would make me laugh at things that should make you laugh. But it seems effects wear off after couple days...

 

[Flynn]

I have tried lisuride, it definitely produces good mood, and would make me laugh at things that should make you laugh. But it seems effects wear off after couple days...

\how long did you take it and at what dose?

Were there any major side effects?

 

[Orion]

\how long did you take it and at what dose?

Were there any major side effects?

50-100mcg per day for about a week, effects wore of after about 2-3 days.

No side effects, but long term use is considered risky.