ESTRONE VS ESTRADIOL RATIO as the cause of PFS and hairloss.

[Shadow]

You guys need to understand that histidine is also made in pentose pathway. The pathway that makes NADPH. So if that pathway is not working, then histidine is down. And you experience histamine reactions to stuff, like mold etc. The minute you recover NADPH pathway. histidine starts going up. And all allergies go away.

This makes so much sense! Before my ED problems started(while on SSRIs) I developed this freaking hives/urticaria all over the body... Also, a common symptom of post ssri is reactions to stuff like foods, smells...

 

[Jaxx]

This makes so much sense! Before my ED problems started(while on SSRIs) I developed this freaking hives/urticaria all over the body... Also, a common symptom of post ssri is reactions to stuff like foods, smells...

What this hives thing something permanent or a temporarily thing? I had a very bad hives reaction while on SSRI, but it was more like a 2 week outbreak which even freaked out my GP. I basically got a new layer of skin after this =|

 

[Shadow]

What this hives thing something permanent or a temporarily thing? I had a very bad hives reaction while on SSRI, but it was more like a 2 week outbreak which even freaked out my GP. I basically got a new layer of skin after this =|

Still have, but it fluctuates in severity, sometimes my skin only goes red after a scratch, other times it itch like hell and I got dermographism too.

 

[Helen]

Still have, but it fluctuates in severity, sometimes my skin only goes red after a scratch, other times it itch like hell and I got dermographism too.

I was so far away from medicine when I got sick, I have neven been to a doctor and I never knew what ceruloplasmin was. I was like many here was looking for solutions. had crazy hives, had perfume sensitivities, had mold allergies like crazy. they wanted to put me on SSRI and did , put me on paxil. I was on it for 3 months. gained tons of weight on that crap and felt like death. Then the fun part started , I could not feel my head, I had crazy sleeping episodes like when I felt I was going go die, and adrenaline kicked me out of my sleep to keep breathing since hypoxia was just too much.

Histidine is needed to take oxygen and carry it, without histidine oxygen is basically does not get on hemoglobin. Histidine binds it

So you experience hypoxia. and that is why ozone always helped me. I felt much better on ozone in days.

And if I took huge B vitamins vitamin C and E I felt even better. I did liver flushes, and also I did sort of electrolytes protocol. And it all just went away. ARL helped by giving me cofactors.

I think anyone can be fixed from this in 2-3 months. Neurons will restore on B1. even parkinsons goes away on that. the latest thing for parkinsons is b1.


Ray Peat's diet alone is a NO NO. Sugar will kill B1. And that is how most people got the b1 deficiency in a first place by just pounding sugars. You need to eat the diet which is really high in b1 and moderate in carbs. No high and not low. Moderate.

 

[Shadow]

I was so far away from medicine when I got sick, I have neven been to a doctor and I never knew what ceruloplasmin was. I was like many here was looking for solutions. had crazy hives, had perfume sensitivities, had mold allergies like crazy. they wanted to put me on SSRI and did , put me on paxil. I was on it for 3 months. gained tons of weight on that crap and felt like death. Then the fun part started , I could not feel my head, I had crazy sleeping episodes like when I felt I was going go die, and adrenaline kicked me out of my sleep to keep breathing since hypoxia was just too much.

Histidine is needed to take oxygen and carry it, without histidine oxygen is basically does not get on hemoglobin. Histidine binds it

So you experience hypoxia. and that is why ozone always helped me. I felt much better on ozone in days.

And if I took huge B vitamins vitamin C and E I felt even better. I did liver flushes, and also I did sort of electrolytes protocol. And it all just went away. ARL helped by giving me cofactors.

I think anyone can be fixed from this in 2-3 months. Neurons will restore on B1. even parkinsons goes away on that. the latest thing for parkinsons is b1.


Ray Peat's diet alone is a NO NO. Sugar will kill B1. And that is how most people got the b1 deficiency in a first place. You need to eat the diet which is really high in b1 and moderate in carbs. No high and now low. Moderate.

I eat a lot of sugar! Damn

 

[Helen]

I eat a lot of sugar! Damn

Dude, it is time for you to get well. I can feel it. Just power thru it.

 

[supernature]

Histidine is needed to take oxygen and carry it, without histidine oxygen is basically does not get on hemoglobin. Histidine binds it

...

 

[Helen]

Any idea/theory how hemoglobin would look like in CBC if histidine is too low, so hypoxia would be present for ex. ?
Maybe low histidine, then low hemoglobin ?

Yes you might have low hemoglobin

I think we have 2 cases here, in one case there is super activation of NADPH oxidase going on and this also creates superoxide

This is why we have people with high and low testosterone and DHT.

So in one case, there might be too much NADPH is made and some of it is going to NADPH oxidase and creates oxidative stress that way.

And in another case it could be no NADPH and you create oxidative stress another way since you cant recycle glutathione.

So it is b1 or b2 deficiencies. glutathione needs to be recycled by 2 things, FAD and NADPH. If there is no NADPH , then glutathione is not recycled, and if there is no FAD, then glutathione is not recycled.

If there is no FAD , then I assume you have too much of NADPH since it is not being used. and it goes into NADPH oxidase which creates oxidative stress.
And if you are missing NADPH , then you cant recycle glutathione and you are low in all hormones .


IN reality there are 2 deficiencies always, FAD and NADPH, it is just relative and when you start feeding one, the other one goes way too low.


Both of these cases recycle glutathione badly. And both of these cases can have not working Nitric Oxide and create tons of oxidative stress.

It is all about glutathione recycling, and it is either FAD or NADPH.

2 cases will need one will need more b2 and supportive supps, and another case will need more b1 and supportive supps.

I will try to write it out for people later one. With high and low DHT and testosterone.

 

[Ben123]

So what is a good vitamin b complex?

 

[Jaxx]

I gave you practical advice. And I told you what to do precisely. There is electrolytes protocol for that which has PFS protocol in it.

This is what I wrote to you.

It is not a mold problem, is it just a MAO problem.

You mentioned MAO a couple of times, some time ago. How would MAO inhibition come into play here?

 

[supernature]

You mentioned MAO a couple of times, some time ago. How would MAO inhibition come into play here?

...

 

[Yura]

es, this is why it is crucial to increase NADPH and FAD which will increase glutathione recylcling, which will increase active ascorbate, which will recycle bh4 , which will make sure that NO synthase creates NO and no superoxide. This is why increasing NO with supplements or precursors without propery Bh4 levels will lead to veins problems .

This is partly why many sports people die. Since they all try to increase NO levels with supps

Is this also true for taking L arginine or version with better absorbtion L arginine alpha ketoglutarate?? This will increase NO a lot right? Last thing what I want to do is damage my veins even more. Mine are fucked up from oxidative stress, collagen/elastin loss or I think both..

Btw "I think the proper way to do this would be to lower ARL dosages to once a day . And increase needed aminos during the day."
this is exactly what I said. Taking 120mg of zinc, 800mcg of chromium etc. doesn't make any sense..

You write about histidnine, histidine like crazy here. SO I should probably continue taking histidine.. But what about arginine?

 

[Jaxx]

I think what its meant is the opposite, MAO is suppressed and cant be used due to interactions it has on other levels. Its suppressed for the reasons mentioned and it takes to work on the reason/s so it can go up and stop making issues with mold for ex.

Progesterone would increase MAO, thus inhibiting neurotransmitters.

 

[supernature]

Progesterone would increase MAO, thus inhibiting neurotransmitters.

...

 

[RebelWithACause]

This is speculation, take it with a grain of salt:

I think finasteride causes low estrogen side effects after a while. Wether it is the expression of estrogen on the receptor or ACTUAL low estrogen I don't know.

Friends of mine who do bodybuilding feel similar to people on PFS. Joint pain, no sex drive, no erections, stomach issues/bloated stomach, brainfog, anxiety, OCD thinking, bad stools, low confidence, suicidal thoughts, irritated and angry. Creatine also made them feel WORSE - it increases DHT. This results in more competition between DHT and estrogen. Just like me after I first quit finasteride. For some of them it took months to be back to normal. Even when their estrogen in bloodwork was GOOD. They still felt a lot of the side effects.

Similar to how guys have good blood work after quitting finasteride but they still feel like shit!

It seemed the longer they were in low estrogen state, the longer it took to feel back to normal.

One guy told me when he was on trenbolone (progestin) he would still have high sex drive even though he crashed his estrogen to the ground. When he came off trenbolone to TRT dosage he did not have any libido and low estrogen side effects. It could be that progestins can mitigate some of low estrogen side effects.

So if you are on finasteride you might still have some sex drive but when you go off now you are on just testosterone with low/crashed estrogen. When you have been in that state (while on finasteride) for a long time you do not recover instantly. It can take a pretty long time. Especially if you have low T. Because you aromatise a lot less to estrogen. And even if you aromatise the effects of E2 do not seem to be back instantly.

I think this is why people also feel bad on R-Andro a lot. When you already have feel low estrogen you add in a compound that lowers it even further!

Since taking finasteride I have felt low-ish estrogen in general. Even after recovering and fixing brainfog/libido I still feel a bit low estrogen (like joints and dry-ish skin).

This is why a lot of PFS guys react bad to zinc. This lowers estrogen even further.

Two weeks ago I took high zinc (50mg) for a while. I took the zinc with copper. While it did boost my libido in beginning. After 5 days I felt low estrogen. Hot flashes, sweating, anxiety and joint pain. Also extremely tired. This was gone after 5 days of eating low zinc.

I think this is why people react good to supplemented estrogen (+ DHT - probably don't even need it). You could probably take something like dianabol or a highly aromatising compound and feel better when you take it. Don't recommend that.

I think you can stop hairloss but I never felt good on anything that slowed or stopped my hairloss. For me it seems hair or mental health.

 

[Helen]

This is speculation, take it with a grain of salt:

I think finasteride causes low estrogen side effects after a while. Wether it is the expression of estrogen on the receptor or ACTUAL low estrogen I don't know.

Friends of mine who do bodybuilding feel similar to people on PFS. Joint pain, no sex drive, no erections, stomach issues/bloated stomach, brainfog, anxiety, OCD thinking, bad stools, low confidence, suicidal thoughts, irritated and angry. Creatine also made them feel WORSE - it increases DHT. This results in more competition between DHT and estrogen. Just like me after I first quit finasteride. For some of them it took months to be back to normal. Even when their estrogen in bloodwork was GOOD. They still felt a lot of the side effects.

Similar to how guys have good blood work after quitting finasteride but they still feel like shit!

It seemed the longer they were in low estrogen state, the longer it took to feel back to normal.

One guy told me when he was on trenbolone (progestin) he would still have high sex drive even though he crashed his estrogen to the ground. When he came off trenbolone to TRT dosage he did not have any libido and low estrogen side effects. It could be that progestins can mitigate some of low estrogen side effects.

So if you are on finasteride you might still have some sex drive but when you go off now you are on just testosterone with low/crashed estrogen. When you have been in that state (while on finasteride) for a long time you do not recover instantly. It can take a pretty long time. Especially if you have low T. Because you aromatise a lot less to estrogen. And even if you aromatise the effects of E2 do not seem to be back instantly.

I think this is why people also feel bad on R-Andro a lot. When you already have feel low estrogen you add in a compound that lowers it even further!

Since taking finasteride I have felt low-ish estrogen in general. Even after recovering and fixing brainfog/libido I still feel a bit low estrogen (like joints and dry-ish skin).

This is why a lot of PFS guys react bad to zinc. This lowers estrogen even further.

Two weeks ago I took high zinc (50mg) for a while. I took the zinc with copper. While it did boost my libido in beginning. After 5 days I felt low estrogen. Hot flashes, sweating, anxiety and joint pain. Also extremely tired. This was gone after 5 days of eating low zinc.

I think you can stop hairloss but I never felt good on anything that slowed or stopped my hairloss. For me it seems hair or mental health.

This is exactly what I wrote in the opening post. )) If you have low DHT and low estradiol in PFS> means that your estrone is high. Estrone does not work as estrogen, since it is too weak. but it can stop the axis.

 

[RebelWithACause]

This is exactly what I wrote in the opening post. ))

Lol you are right. I read it very fast. I wrote this down on my phone two weeks ago after talking to bodybuilders. I think your theory is right. Closer then the other theories I have read.

 

[Helen]

Lol you are right. I read it very fast. I wrote this down on my phone two weeks ago after talking to bodybuilders. I think your theory is right. Closer then the other theories I have read.

You probably don't even need to add DHT with estrogen. Just add estrogen and you will feel better. I can almost guarantee this.

it is not about adding estrogen , bud. It wont stick. It is about converting estrone into estradiol, estradiol is the strong estrogen. And when you convert estrone to estradiol, you will have higher DHT and higher estradiol, and it is exactly as taking DHT with estradiol together.

You dont want to take estrogen it will inhibit your LH.

If you do have low DHT and lowish or normal estradiol in blood , then you have this estrone problem. And you need to increase NADPH.

If you have high DHT and high estradiol. Then you have prolactin problem. And you need to lower NADPH with FAD


Both of these problems have a problem with nitric oxide. Since in one NADPH is missing, and in another FAD is missing. |But you need NADPH and FAD to recycle glutathione with. And without glutathione you will never have Nitric oxide. You will have tons of superoxide.

 

[Shadow]

This is exactly what I wrote in the opening post. )) If you have low DHT and low estradiol in PFS> means that your estrone is high. Estrone does not work as estrogen, since it is too weak. but it can stop the axis.

My question is: is this enough to cause severe issues like bad insomnia, nerve pain and things like that? Even in women?

 

[Helen]

My question is: is this enough to cause severe issues like bad insomnia, nerve pain and things like that? Even in women?

lack of glutathione is enough to cause parkinsons, and neurological symptoms. Just look up Beri Beri, this is b1 deficiency, it causes encephalopathy. Wernicke koraskoff.

This is why alcoholics get it , alcohol kills B1, and people get inflammed brain.


You need to test your hormones, DHT and testosterone and estradiol and estrone. If you have high DHT and test, that means you are making NADPH but you are not making FAD.

If you have low test and DHT , then you dont make NADPH. And you need to look into which component you are missing to make it. if it is niacin or b1.