ESTRONE VS ESTRADIOL RATIO as the cause of PFS and hairloss.

[Helen]

Lol you are right. I read it very fast. I wrote this down on my phone two weeks ago after talking to bodybuilders. I think your theory is right. Closer then the other theories I have read.

This is why B vitamins with HCL were helping you , since there is b1 or b2 in there.

 

[RebelWithACause]

it is not about adding estrogen , bud. It wont stick. It is about converting estrone into estradiol, estradiol is the strong estrogen. And when you convert estrone to estradiol, you will have higher DHT and higher estradiol, and it is exactly as taking DHT with estradiol together.

You dont want to take estrogen it will inhibit your LH.

If you do have low DHT and lowish or normal estradiol in blood , then you have this estrone problem. And you need to increase NADPH.

If you have high DHT and high estradiol. Then you have prolactin problem. And you need to lower NADPH with FAD

OK that is interesting.

This is why B vitamins with HCL were helping you , since there is b1 or b2 in there.

Yes. I think so too.

 

[Shadow]

lack of glutathione is enough to cause parkinsons, and neurological symptoms. Just look up Beri Beri, this is b1 deficiency, it causes encephalopathy. Wernicke koraskoff.

This is why alcoholics get it , alcohol kills B1, and people get inflammed brain.


You need to test your hormones, DHT and testosterone and estradiol and estrone. If you have high DHT and test, that means you are making NADPH but you are not making FAD.

If you have low test and DHT , then you dont make NADPH. And you need to look into which component you are missing to make it. if it is niacin or b1.

I asked about women because sexual sides in post ssri seems to affect much more the males, as far as I see, females have more mental and other neurological issues.

 

[Helen]

I asked about women because sexual sides in post ssri seems to affect much more the males, as far as I see, females have more mental and other neurological issues.

Females might notice it less, since they need less of nitric oxide.))

 

[Helen]

I asked about women because sexual sides in post ssri seems to affect much more the males, as far as I see, females have more mental and other neurological issues.

Here is an interesting read for you . Three weeks on intravenous thiamine (vitamin B1)

 

[HerrFisch]

Here is an interesting read for you . Three weeks on intravenous thiamine (vitamin B1)

This girl claims Thiamine Hcl makes her nauseous and benfotamine doesnt. I feel similar. Why's that ?

 

[vicecaz]

@Helen

I do have high test/DHT, and high prolactin, so I'd need to lower NADPH with FAD apparently . How one manage to do so, anything special?


I started taking vitamin B1 3 days ago, 1500mg/day , as those issue with sugar are definitely familiar to me

Already following electrolytes protocol

 

[Admiral]

We could use some form of guideline for those with high T/DHT/E and those with low. My hormones are shut for years now - each one is lowish or even below reference range.

Would that mean B1 might be helpful?

 

[Yura]

@Helen you talk about low carnitine, low NO, low arginine. Can you pls answer my question if it's a good idea to take L carnitine, L arginine???

 

[Helen]

I am still looking into pentose pathway to see what to do .

It is not about taking arginine or histidine.

there are 2 cases here and in one case it will be not good.

And it is not about b1 also. It is about FAD and NADPH. Too high levels of NADPH wll block pentose. and this will cause low histidine.

Low NADPH can increase pentose too much and it will cause high histidine.


So low and high hemoglobin in people, I would assume.

 

[Yura]

lol if it's not about taking B1, histidine and amino acids overall etc.. why it is core of your protocol lol.. I understand that when everything works how it should. You need very little of every nutrient and just from regular diet. But obviously if you recommend 600 mg of B1 etc.. It is about them to get out of this shit show.. So I am asking if hydrolyzed whey + hydrolyzed collagen is enough or we should add free amino acids in bigger amount.. The problem is we will not find out what amino acids we need so..

 

[Helen]

We could use some form of guideline for those with high T/DHT/E and those with low. My hormones are shut for years now - each one is lowish or even below reference range.

Would that mean B1 might be helpful?

I am trying to figure out the protocol and the cause. People asking for solutions. I dont know them yet.

 

[Helen]

lol if it's not about taking B1, histidine and amino acids overall etc.. why it is core of your protocol lol.. I understand that when everything works how it should. You need very little of every nutrient and just from regular diet. But obviously if you recommend 600 mg of B1 etc.. It is about them to get out of this shit show.. So I am asking if hydrolyzed whey + hydrolyzed collagen is enough or we should add free amino acids in bigger amount.. The problem is we will not find out what amino acids we need so..

This is the PFS thread where I suggested the theory. Now we are discussing this theory. I outlined at least 2-3 cases from the people tests that we saw with high and low testosterone. and DHT/ I have no idea why you are telling me that the core of my protocol is b1.and histidine. i just wrote that histidine is not made if pentose is not working. So when you make pentose working, histidine will be made.

I outlined other case, in which histidine will be high and hemoglobin will also be high. You need to read carefully.


If you take whey take it. what does it have to do with this theory .

Every single time I try to discuss things, you come and start asking for protocols. LIke hydrogen water. I said no one knows what it does, and I described to you what I think it does. after studying it. Is it good , for some people yes. May be it is good for all people. I have no idea. I have no time machine to go and check it out in the future.

Or you just want me to lie to you and say , hydrogen water will be your panacea. I am just a poster like you on this forum. I do inhalations myself.

I told you to try ARL, keep taking it, it does not stop me from discussing ARL and my opinions about it. And it does not stop me from discussing hydrogen water and its pluses and minuses for me. What does this have to do with you. I dont get.

or you just want me to post protocols? I am here to hang out and discuss things, not post protocols or answer never ending questions about whey protein.

there is an electrolytes protocol. YOu can take it and see if it works, for you. If you think it is about b1 and histidine , it is not. I have no idea where you found it there. Since PFS has more than one case. I keep writing about it but no one listens.

In this thread I am trying to discuss PFS.

I give people ideas, and people need to go and research it .

You want us here to just sit and not evolve? just post some idea and sit with it? and do nothing?
I am trying to find a protocol which will work the best for PFS. And if I figure out something that will be completely opposite to what I said before, I will say it. and change it. TRUST Me on that one.


These are theories and I did not even want to post protocols yet. People asked me. I wanted to post the protocol when we have people gettting cured left and right with it. As far as now, the only reason that stuff is posted for people to try it who were here, and who can afford it. And if it works for them, and it has a good track record for diffrenent cases, then we can actually show this protocol to all other people. This is why this forum is CLOSED to the public.

Basically we are all evolving and creating this protocol together.

 

[Helen]

@Yura I am still looking how to pin point everything for every case.

Actually, some people did great with niacin therapy after using steroids. ( read some Hoffer)) NADPH is what makes testosterone. and DHT . So to make NADPH, you need niacin, b1 and phosphorus.

I know the regulation of NADPH is more complex, but this is what I am trying to figure out now for most cases, since we do have cases here where test levels are high. along with DHT.


I understand you crashed from steroids. Did you crash from DECA or just regulate steroids? You dont have bile, bile is made with NADPH and vitamin C

Some people crash from steroids and cant make niacin in the body, to make niacin you need iron , b2 and b6.


So as you can see it is not about b1, it is about FAD and NADPH. which are made with tons of shit, and b1 is just one of the nutrients.

 

[Yura]

Like I said my biggest issue was that I experienced crazy collagen/elastin loss ( damaged blood vessels like you see in old people with red legs. spider veins..) and also issues with joints, spine.. and I can't figure out what was the culprit. Probably everything from oxidative stress, free metals in the blood to deficiencies and body completely out of homeostasis.. This is by far the worst problem I had/have.. To see in front of my eyes like I aged 20 years in like 6 months or so and if I die any moment from some aneurysm or what.. Other issues like digestion, chronic fatigue was there a long time before this and it was a joke in comparison with this body degradation..

 

[Area-1255]

This makes so much sense! Before my ED problems started(while on SSRIs) I developed this freaking hives/urticaria all over the body... Also, a common symptom of post ssri is reactions to stuff like foods, smells...

Serotonin also causes itching [pruritis] [1] and hives [uritcaria] though [2]. Like Histamine, it can be an inflammatory-mediator [3].

 

[Shadow]

Serotonin also causes itching [pruritis] [1] and hives [uritcaria] though [2]. Like Histamine, it can be an inflammatory-mediator [3].

From what I read there, I think that mine is histamine related. A curious fact is that dexamethasone did nothing and a single pill of cetirizin did the trick for 3+ days.

But I remember having a very different kind of itch on my legs(happened 90% of the time after taking my pants off), was intense and didnt left my skin red and with dermographism, it subsided. Sometimes I feel a different itch, but its rare and only appeared after SSRI, and I cant tell if it is the same that I had on my legs.

 

[talesofdaHustle]

I have never taken fin, but have high DHT (2101 pmol/L) , Free Test (521 521 pmol/L, and High prolactin (10 ug/L). Would that mean I am making NADPH but not making FAD ? @Helen

 

[Area-1255]

From what I read there, I think that mine is histamine related. A curious fact is that dexamethasone did nothing and a single pill of cetirizin did the trick for 3+ days.

But I remember having a very different kind of itch on my legs(happened 90% of the time after taking my pants off), was intense and didnt left my skin red and with dermographism, it subsided. Sometimes I feel a different itch, but its rare and only appeared after SSRI, and I cant tell if it is the same that I had on my legs.

Yeah many times its Histamine or both, too. Especially if severe. I think with thinks like wounds that "itch" is more than likely Serotonin. As serotonin can attach to Platelets near the site of a Wound.

 

[ruprmurdoch]

lack of glutathione is enough to cause parkinsons, and neurological symptoms. Just look up Beri Beri, this is b1 deficiency, it causes encephalopathy. Wernicke koraskoff.

This is why alcoholics get it , alcohol kills B1, and people get inflammed brain.


You need to test your hormones, DHT and testosterone and estradiol and estrone. If you have high DHT and test, that means you are making NADPH but you are not making FAD.

If you have low test and DHT , then you dont make NADPH. And you need to look into which component you are missing to make it. if it is niacin or b1.

Isn't it in the end all about sulfur? Thiamine contains sulfur, Acetalozamide contains sulfur, biotin (b7) conatins sulfur, DMSO, MSM. All those strange diseases like Lesniowski Crohn, and other you mentioned above are healed after you start using sulfur containing substance. I heard that for example Lesniowski Crohn is cured after using DMSO. There are studies that show sulfur containing stuff heal progestins users.