FINASTERIDE SIGNIFICANTLY UPREGULATES ANDROGEN RECEPTOR in this study ( PROTOCOLS and discussions for PFS)

[Troy]

But since I know how progestins work based on progesterone level, then I think we have two cases here.


It says SIGNIFICANT upregulation. Which is understandable. And it says upregulated for months and years afterwords.
Finasteride upregulates expression of androgen receptor in hyperplastic prostate and LNCaP cells: implications for chemoprevention of prostate cancer. - PubMed - NCBI

So for case with upregulated receptors / this is why DHTs like proviron , or masterone dont do anything. Since they are not even close to DHT for anabolism

And only things like anavar can work which have crazy anabolic effect and will downregulate the receptor the most.


This is why things like anavar actualy downregulate the receptor and then when you get off you get supersexuality. since estrogen starts pouring in.


In cases of downregulated receptors, dutasteride will work. or any 5 AR antagonist. with no progestin like action, Just blocks 5 AR.

So most of us need to downreglate the ar. How do we do this with the zinc finger method? Copper and histidine?

 

[IHateFin]

So most of us need to downreglate the ar. How do we do this with the zinc finger method? Copper and histidine?

Anavar

 

[IHateFin]

I feel like after the crash androgen receptors probably don't stay up regulated... if that were the case we would be stuck hyper androgenic and we all seem hypo androgenic... I think at a point the receptors are sensitive then the rush of dht down regulates them and at the same time the spike in dht causes a negative feedback loop and the HPTA inhibits its self. Once it slowly comes back receptors are in a lot of cases still fried

 

[Troy]

Anavar

I want to do it with the zinc finger method, not the drug route. I don't do drugs any more.

 

[TubZy]

Yeah, this is what happened to me. Took superdrol, then came off, receptors were downregulated, got flooded with estrogen then DHT (I did no PCT and felt great coming off cycle, zero negative PCT symptoms). I had insane libido and lot of sebum post cycle. About 3-6 months later I noticed my hair thinned out very quick, then started to even get thinner after that. Then I took fin which stopped the hair thinning and I regained a lot of my hair back since it upregulated androgen receptors, but at the cost of very low libido and a million other sides. I also used the topical drug RU58841 during a short time coming off fin which blocks the AR which would even upregulate the AR even MORE, same reason why @jacknap crashed from RU58841 (different from the anti prog drug RU on here). Funny thing is I responded greatly both to fin and RU58841 from a hair perspective, both of them totally reversed and regrew my hair in a short period of time, but at a cost.

So I went from normal receptors then to downregulated receptors then to upregulated receptors and now need to downregulate them again LOL

I do agree that most steroids won't work. Some steroids that could work are potentially anavar, turinabol or superdrol, but the safe more balanced route is zinc finger or ARL/TEI that does it slower...hoping to fine tune the electrolyte (zinc finger) protocol soon when @Helen finalizes it in a new thread/google doc to avoid confusion.

 

[IHateFin]

Yeah, this is what happened to me. Took superdrol, then came off, receptors were downregulated, got flooded with estrogen then DHT (I did no PCT and felt great coming off cycle, zero negative PCT symptoms). I had insane libido and lot of sebum post cycle. About 3-6 months later I noticed my hair thinned out very quick, then started to even get thinner after that. Then I took fin which stopped the hair thinning and I regained a lot of my hair back since it upregulated androgen receptors, but at the cost of very low libido and a million other sides. I also used the topical drug RU58841 during a short time coming off fin which blocks the AR which would even upregulate the AR even MORE, same reason why @jacknap crashed from RU58841 (different from the anti prog drug RU on here). Funny thing is I responded greatly both to fin and RU58841 from a hair perspective, both of them totally reversed and regrew my hair in a short period of time, but at a cost.

So I went from normal receptors then to downregulated receptors then to upregulated receptors and now need to downregulate them again LOL

so anadrol and anavar could both cure pfs?

i copped some var from russion star pep so ill report on my log.

ever though about trying that stuff again, tubz?

 

[Helen]

I feel like after the crash androgen receptors probably don't stay up regulated... if that were the case we would be stuck hyper androgenic and we all seem hypo androgenic... I think at a point the receptors are sensitive then the rush of dht down regulates them and at the same time the spike in dht causes a negative feedback loop and the HPTA inhibits its self. Once it slowly comes back receptors are in a lot of cases still fried

they stay upregulated all the time. the androgen receptor simply work on zinc finger and arginine.

there is no upregultaed or downregulated. If zinc finger is upregulated you have low estrogen stopping it from working. If you have it downregulated you have prolactin shutting you down

So drugs will never CURE PFS< you will be flying from one side to another

Exactly if the receptors are upregulated , HTPA inhibits itself and you run on low estrogen. take AI and tell me how you will be hyperandrogenic



People seem to miss what I am saying.


You need 3 systems working properly for AR and androgen receptor to work properly


IT is cysteine system( glutathione) it is histidine system ( histamine ) and arginine system( nitric oxide)


This is because androgens release nitric oxide. and so when there is no nitric oxide, body will stop androgen production

Same as if there is no glutathione body will shut you down also.

Now tell me how taking drugs will fix these systems.

Even before fin or SRRIs you guys had problems, with these systems

And your crazy libido had nothing to do with normal libido. It was just histamine induced itch. It was not normal androgen receptor functioning


SO taking drugs like anavar, will put you from low histamine state to high . That is all. and you will get crazy hairloss. stupid obsessive behaviour about sex etc

this is not Normal androgen functioning. This is as sick as being in PFS state


This is why I am saying balancing these systems can be achieved by some drug))

It is all about minerals balance inside of your body.

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .


Since with drugs youdont fix minerals, you just fly from one side to another. With major problems on all sides

Like you think Tubzy wll live with a hairloss LOL


NO he wont. If he uses superdrol or anvar., fixes PFS, get histamine imbalance and what's there. There will be many histamine problems. And then he will start fixing his hair LOL which he will lose in weeks

And go right back to PFS again.

 

[Helen]

Hairloss needs to be solved by making nitric oxide work. Not by lowering or increasing zinc finger. And flying like a yo yo from high histamine state to low LOL


Nitric oxide in the body will work only when you have antioxidation in the cell. and that antioxidation is made by histidine and cysteine. SODs


this is why people take NO precursors along with SODS and grow all their hair back and have crazy libido at the same time LOL

 

[supernature]

I've been getting libido boost from Brewer's yeast, so maybe the amino ratio of cysteine , arginine, and histidine is good.

...

 

[Ingeno]

this is why people take NO precursors along with SODS and grow all their hair back and have crazy libido at the same time LOL

But is this a solid long term cure, or just a patch?

 

[Minime]

It is all about minerals balance inside of your

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .

Is ARL/TEI enough though? Would aminos also be needed? I don’t think I’m getting any aminos in my ARL protocol. The ARL sups seem to be having a very negative impact on my androgens.

 

[Ingeno]

I also wonder if whey is enough or that it's too many amino's at once and they all trying to compete for absorption. Perhaps the important ones like histidine, cysteine and arginine need to be supplemented apart from the other amino's to make sure they get absorbed.

 

[Slayo]

they stay upregulated all the time. the androgen receptor simply work on zinc finger and arginine.

there is no upregultaed or downregulated. If zinc finger is upregulated you have low estrogen stopping it from working. If you have it downregulated you have prolactin shutting you down

So drugs will never CURE PFS< you will be flying from one side to another

Exactly if the receptors are upregulated , HTPA inhibits itself and you run on low estrogen. take AI and tell me how you will be hyperandrogenic



People seem to miss what I am saying.


You need 3 systems working properly for AR and androgen receptor to work properly


IT is cysteine system( glutathione) it is histidine system ( histamine ) and arginine system( nitric oxide)


This is because androgens release nitric oxide. and so when there is no nitric oxide, body will stop androgen production

Same as if there is no glutathione body will shut you down also.

Now tell me how taking drugs will fix these systems.

Even before fin or SRRIs you guys had problems, with these systems

And your crazy libido had nothing to do with normal libido. It was just histamine induced itch. It was not normal androgen receptor functioning


SO taking drugs like anavar, will put you from low histamine state to high . That is all. and you will get crazy hairloss. stupid obsessive behaviour about sex etc

this is not Normal androgen functioning. This is as sick as being in PFS state


This is why I am saying balancing these systems can be achieved by some drug))

It is all about minerals balance inside of your body.

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .


Since with drugs youdont fix minerals, you just fly from one side to another. With major problems on all sides

Like you think Tubzy wll live with a hairloss LOL


NO he wont. If he uses superdrol or anvar., fixes PFS, get histamine imbalance and what's there. There will be many histamine problems. And then he will start fixing his hair LOL which he will lose in weeks

And go right back to PFS again.

I think i had no NO pre pfs, no muscle pump at the gym, zero.

I took dutasteride before fin, it gave me INSANE libido, to the point i was thinking i was going mad, then i stopped it because it increased hairloss a lot, so i took fin and i got low libido (and it didn't help my hairs)

 

[noprop]

What are SODS?
Antioxidants: are they the key or taking the things in order to get running properly the antioxidation process by itself (homeostasis)? Whatever things they are (aminos/vits...)
Great antioxidants are: R-ALA! It helps other antioxidants to work better. OPC (grape seed extract, very powerful) and astaxanthine (light dht inhibitor)
Oxygen metabolism in the cell: organic! Germanium

Detox: help through Enterosgel (against pathogens, heavy metals, toxins), R-ALA: both pass the BBB
iodine, zeolith, bentonit, aminos to build glutathione, glutathione (reduced or s-acetyl GL.)

Which one is better: reduced or s-acetyl glut.? THX

 

[HerrFisch]

@noprop


There you go.

SOD are enzymes turning Superoxides into H2o2 for example.
And after that you have catalase to turn h2o2 into water and oxygen.

 

[wuf]

I feel like after the crash androgen receptors probably don't stay up regulated... if that were the case we would be stuck hyper androgenic and we all seem hypo androgenic... I think at a point the receptors are sensitive then the rush of dht down regulates them and at the same time the spike in dht causes a negative feedback loop and the HPTA inhibits its self. Once it slowly comes back receptors are in a lot of cases still fried

You are wrong.
i HAVE pfs FROM 12/13 YEARS and after 6 years having it, I got tested and doctors cut me a piece of penis' skin to analise it and they saw that AR is way up up-regulated.
So what @Helen is saying is fucking right.
I do have study about this and about my singular case...they testes something like 18 guys, all had the same issue with upregulated AR.

 

[Helen]

You are wrong.
i HAVE pfs FROM 12/13 YEARS and after 6 years having it, I got tested and doctors cut me a piece of peni's skin to analise it and they saw that AR is way up up-regulated.
So what @Helen is saying is fucking right.
I do have study about this and about my singular case...they testes something like 18 guys, all had the same issue with upregulated AR.

Holy shit, bro. they cut a piece of your penis. you are a crazy italian. )) same as me a crazy russian LOL

You deserve to get cured , bud. Just for this. I think we are very close to getting this thing SHUT down for ever

 

[Troy]

they stay upregulated all the time. the androgen receptor simply work on zinc finger and arginine.

there is no upregultaed or downregulated. If zinc finger is upregulated you have low estrogen stopping it from working. If you have it downregulated you have prolactin shutting you down

So drugs will never CURE PFS< you will be flying from one side to another

Exactly if the receptors are upregulated , HTPA inhibits itself and you run on low estrogen. take AI and tell me how you will be hyperandrogenic



People seem to miss what I am saying.


You need 3 systems working properly for AR and androgen receptor to work properly


IT is cysteine system( glutathione) it is histidine system ( histamine ) and arginine system( nitric oxide)


This is because androgens release nitric oxide. and so when there is no nitric oxide, body will stop androgen production

Same as if there is no glutathione body will shut you down also.

Now tell me how taking drugs will fix these systems.

Even before fin or SRRIs you guys had problems, with these systems

And your crazy libido had nothing to do with normal libido. It was just histamine induced itch. It was not normal androgen receptor functioning


SO taking drugs like anavar, will put you from low histamine state to high . That is all. and you will get crazy hairloss. stupid obsessive behaviour about sex etc

this is not Normal androgen functioning. This is as sick as being in PFS state


This is why I am saying balancing these systems can be achieved by some drug))

It is all about minerals balance inside of your body.

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .


Since with drugs youdont fix minerals, you just fly from one side to another. With major problems on all sides

Like you think Tubzy wll live with a hairloss LOL


NO he wont. If he uses superdrol or anvar., fixes PFS, get histamine imbalance and what's there. There will be many histamine problems. And then he will start fixing his hair LOL which he will lose in weeks

And go right back to PFS again.

So the male pattern baldness itch on our heads is a histamine itch too I'll take it?

To fix our hairloss problem, will we need to take stuff for life or will we be able to fix it in one hit?

 

[Troy]

Holy shit, bro. they cut a piece of your penis. you are a crazy italian. )) same as me a crazy russian LOL

You deserve to get cured , bud. Just for this. I think we are very close to getting this thing SHUT down for ever

I've had enormous improvement 4 weeks after stopping a protocol of aminos + potassium chloride. I got all the aminos including histidine, cysteine and arginine. I improved the more potassium chloride I added in.

Improvements havent really started to kick in until about 3.5 to 4 weeks post stopping the protocol.

 

[Helen]

I think i had no NO pre pfs, no muscle pump at the gym, zero.

I took dutasteride before fin, it gave me INSANE libido, to the point i was thinking i was going mad, then i stopped it because it increased hairloss a lot, so i took fin and i got low libido (and it didn't help my hairs)

Yeah, bud. It is very possible you could have burnt out your NO system before even taking fin.

Minox people are the same. they have no NO. and then they take minox which is nitric oxide, and then they downregulated it even further and when they quit. Boom. they lose all their hairs very fast, faster then if they never took minox.