FINASTERIDE SIGNIFICANTLY UPREGULATES ANDROGEN RECEPTOR in this study ( PROTOCOLS and discussions for PFS)

[BeLikeWater]

You are wrong.
i HAVE pfs FROM 12/13 YEARS and after 6 years having it, I got tested and doctors cut me a piece of penis' skin to analise it and they saw that AR is way up up-regulated.
So what @Helen is saying is fucking right.
I do have study about this and about my singular case...they testes something like 18 guys, all had the same issue with upregulated AR.

Man can you share that study pls? ITS IMPORTANT

 

[IHateFin]

Have you look at teh last emails of postfinasteride syndrome? They are talking that they think our issues come from upregulated androgen receptors, it has been studied that if a receptor is completly upregulated it stops making it works

I have not but I'm learning a lot today it seems haha
This does make sense tho not gunna lie so I'm definitely following... so interesting that now our goal will be shifting to downregulating receptors or really as Helen put it "fix cysteine, arginine and histidine" .
I feel tracktion gaining!

 

[BeLikeWater]

Im just thinking something could be the upregulation the consecuence of 0 androgen activity inside the cell? Maybe some transports between the cell are not working, thats why upregulated receptors its correlated with low libido, etc...

 

[RebelWithACause]

What about carnitine? Carnitine is known to make androgen receptors more sensitive right.

 

[Helen]

Im just thinking something could be the upregulation the consecuence of 0 androgen activity inside the cell? Maybe some transports between the cell are not working, thats why upregulated receptors its correlated with low libido, etc...

I still think there are 2 cases here for sure. And we need to be careful and not fuck ourself up

Sulphoraphane solves the problem with the upregulated Androgen receptor. but I dont think it is the actual receptor which is the problem, but the conditions for the body to open up hormones. Namely hypokalemia.

Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells
Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. - PubMed - NCBI
d,l-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells


So as you see Sulpho is an ideal candidate.

but I think we have 2 cases here and in some cases it will literally fuck people up

 

[IHateFin]

I still think there are 2 cases here for sure. And we need to be careful and not fuck ourself up

Sulphoraphane solves the problem with the upregulated Androgen receptor. but I dont think it is the actual receptor which is the problem, but the conditions for the body to open up hormones. Namely hypokalemia.

Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells
Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. - PubMed - NCBI
d,l-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells


So as you see Sulpho is an ideal candidate.

but I think we have 2 cases here and in some cases it will literally fuck people up

I took this before bed last week and it made me lose my nocturnal wood... hurts me fo sho

 

[vicecaz]

What would be really important is to find a way to say, for sure or at least with a high probability, which case someone is . I'm not sure if a blood/hair test interpretation could be reliable even if we take symptoms in the equation, but who knows . Even 2 people with High prog in blood react differently with Ella which is supposed to block its receptors. Why not choosing something without much side effect or known potential damage or possibility to fuck ourselves in the wrong direction, finasteride/dutasteride/saw palmetto for instance but rather weaker component: Sulphoraphane, licorice root ( as there seems to be 2 cases when people feel good and then crash and the opposite ), Pine pollen comes to mind

Even one's reaction to heavy lifting could be useful

 

[Helen]

I took this before bed last week and it made me lose my nocturnal wood... hurts me fo sho

Lol why would this make you feel good, you downregulate the receptor. the body is already adjusted for it. so when you take something that kills the receptor, you will feel bad. but the idea is that the body starts the LH and pumps more hormones. but for that you need B vitamins and potassium

this is what I am saying. that this is not as straight forward. Upregulate or downregulate.

You should read this thread/ this dude would take like 10-15 sulpho pills at once, and then the improvement will come during the months. I think you can def speed it all up by gulping B1 and potassium.
Restoring androgen sensitivity with epigenetic modulators


this is how I recovered Scenes. I gave him copper histidine.( this killed the androgen and cortisol receptor) then I gave him potassium and magnesium , this started the axes. and his hormones started to go in , and then he took Bs to increase NADPH and FAD. and boom restored.


this stuff is like Clomid but for the DHT. LOL

 

[IHateFin]

Lol why would this make you feel good, you downregulate the receptor. the body is already adjusted for it. so when you take something that kills the receptor, you will feel bad. but the idea is that the body starts the LH and pumps more hormones. but for that you need B vitamins and potassium

this is what I am saying. that this is not as straight forward. Upregulate or downregulate.

You should read this thread/ this dude would take like 10-15 sulpho pills at once, and then the improvement will come during the months. I think you can def speed it all up by gulping B1 and potassium.
Restoring androgen sensitivity with epigenetic modulators


this is how I recovered Scenes. I gave him copper histidine.( this killed the androgen and cortisol receptor) then I gave him potassium and magnesium , this started the axes. and his hormones started to go in , and then he took Bs to increase NADPH and FAD. and boom restored.


this stuff is like Clomid but for the DHT. LOL

Now that was a good read... so interesting!

 

[JDD]

JCI - Substitution of arginine-839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance.

You see if you are missing one thing out of the zinc finger it will get all screwed up

this is why if you are missing arginine metabolism. Your receptor will be not working. No matter what you do

And fin in some cases upregulates Arginase like crazy. And those people have not working receptor. And to fix the receptor , they need to inhbit arginase.

And this will stop hairloss and increase libido at the same time.


Hairloss, is the lack of these amino acids together. Since arginine makes NO and histidine and cysteine protect the cell from oxidation and allow this NO to be made.

This is why people use NO sources and combine it with SODS which is cysteine histidine and they grow hair like crazy and have the sex drive at the same time, since zinc finger is complete Hairloss-reversible.com: Super oxide dismutase and nitric oxide will grow hair



this is why these programs like ARL and TEI they try to balance your arginine cysteine histidine system. And this is how you balance your AR.

I dont think there is such a thing as alpha or being higher than everyone else. You are only better and higher and stronger than any one else, the most balanced you are. Since only in the optimal balance there is the most energy.

And you cant never get that by enhancers of testosteorne or androgens .

Try to balance your histamine nitric oxide and glutathione system. which is histidine cysteine and arginine metabolism and that is your balance.


this is why something like electrolytes protocol can provide everything you need and your body will be balanced

But for people who dont care about their hair. I am pretty sure options above will solve their PFS. but in some cases hair will be gone within weeks. and gone hard

What do you make of this protandim stuff, will it actually increase SOD? Worth taking for hair loss (non-pfs)?

 

[Helen]

What do you make of this protandim stuff, will it actually increase SOD? Worth taking for hair loss (non-pfs)?

according to this dude, it grows hair like crazy ))

I would say it would depend on your body chemistry. but the whole idea of SOds with nitric oxide is valid. that is how you get hair

 

[Helen]

@TubZy @BeLikeWater , when are you finally going to consume some of that anavar, that we have been talking about for so long LOL I think @IHateFin might beat you to it . HAHA

 

[Goose12]

@Helen what would be the best choice for someone needing the opposite of anavar. On r andro I feel terrible but i get a nice little snap back afterwards, but it feels like it crushes estrogen to much. It takes a while for my labido to recover after a cycle.

Would something like 4 andro work? Super 4-Andro Rx – IronMag Labs

 

[MNK99]

YES, for R-Andro (as you know I'm pretty sure). MAYBE, for Anavar. Don't see why not but I haven't used Anavar etc. Some test boosters long ago, and Ostarine only.
FOR, ANAVAR, I think so but I'm not sure. Anavar and sup3r 4 - AnabolicMinds.com
You may need something else for a proper on cycle support and post cycle therapy. I'm sure someone on H/S has done this or will.
Anabolic Minds seems to have a lot of threads with it, one follows:

Andro + Anavar cycle
Andro + Anavar cycle - AnabolicMinds.com

1. 05-12-2017, 04:27 AM
   supadupastar
   Andro + Anavar cycle
   
   I wanna run a 4-Andro/Epi cycle for 8 weeks, but thinking to switch out the Epi for Anavar at week 4 to finish the recomp/cut cycle. Or would it be better to start off with the anavar first? I had good results with Epi (just minor sides), but i wanna try anavar to see how it compares. Cycle would look something like:
   
   4-andro 220mg ed as base (low dose) week 1-8
   Epi-andro 750mg ed week 1-4
   Anavar 50mg week 4-8
   
   Thanks!​
2. 05-12-2017, 02:03 PM
   mjdel05
   
   Why not run car all the way through​

Also a thread there of Anavar + Fin, but I'm not looking at that.​

 

[Admiral]

@TubZy @BeLikeWater , when are you finally going to consume some of that anavar, that we have been talking about for so long LOL I think @IHateFin might beat you to it . HAHA

I tried Anavar years ago. Didn't do anything for PFS.

 

[TubZy]

I tried Anavar years ago. Didn't do anything for PFS.

I thought you didn't take it. Didn't you take stanz instead from the quote below when Niles asked you if you took anavar:

I used stanozole. I think I took 30mg a day (20 morning + 10 evening). Took it during my early PFS years though. Years I only had erection and libido issues and was totally unaware of PFS in the first place.

Didn’t do anything in terms of libido and erection quality. Used it for vain purposes. Made me shredded in just a few weeks. Didn’t help my PFS.

 

[Admiral]

I thought you didn't take it. Didn't you take stanz instead from the quote below when Niles asked you if you took anavar:

Stanozol and anavar are the same, though, aren't they?

 

[BeLikeWater]

I tried Anavar years ago. Didn't do anything for PFS.

Where did you buy it and from what laboratorie was? Dose?

 

[wuf]

Man can you share that study pls? ITS IMPORTANT

Sure.
Going to sleep now.
Let me check in my doc tomorrow, try to find it and post.

 

[IHateFin]

What do you make of this protandim stuff, will it actually increase SOD? Worth taking for hair loss (non-pfs)?

Protandim I used before fin and it stopped my hairloss!! Eventually it got too aggressive for protandim so I got finasteride, but be careful man it has milk thistle which is usually not good for us PFS guys

Edit: nvm you said you don't have PFS haha then yes it will work! It will work extremely well actually... worked for me before this mess and it would sprout like dark ass hairs fast around my hairline seemingly overnight. It's just hard to build muscle on it since that milk thistle is ass