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Patients with glucocorticoid resistance can be treated with alternative broad-spectrum anti-inflammatory treatments, such as calcineurin inhibitors and other immunomodulators, or novel anti-inflammatory treatments, such as inhibitors of phosphodiesterase 4 or nuclear factor κB, although these drugs are all likely to have major side-effects. An alternative treatment strategy is to reverse glucocorticoid resistance by blocking its underlying mechanisms. Some examples of this approach are inhibition of p38 MAP kinase, use of vitamin D to restore interleukin-10 response, activation of HDAC2 expression by use of theophylline, antioxidants, or phosphoinositide-3-kinase-δ inhibitors, and inhibition of macrophage migration inhibitory factor and P-glycoprotein.
yeah, no shit, this is why I used sulphoraphane.
One more time, please refrain from giving me advice.
If I am doing something, I know what it does. Urine modulates all the above things
And there is no glucocorticoid resistance in half of the cases
GR resistance stems from lack of glutathione. This is why DNA reception of cortisol is ZINC FINGER( CYSTEINE and ZINC)
And in PFS zinc is lost into the urine, since B2 is missing. B2 makes CYSTEINE. this is why they use NAC to reverse gluc resistance instead of theophylline in COPD patients.
And this is why many people get rid of all of their PFS with just NAC. but it never lasts. It does not stick. it is a patch.
Since histamine and cysteine will be only allowed in the body when there is potassium
thus I recoverd people by giving them potassium magnesium copper plus histidine and cysteine and B vitamins
This allows the system to go back on.
Since I raise histamines along with cortisol, otherwise both histamine and cortisol are not allowed.
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