$100K For Cure (srs LOL)

[Slayo]

of course it will block the cortisol > I used it with PFS people. many times.

Saliva cortisols are NOT good in my opinion FYI

My saliva cortisol was low, dutch high. I'm also dubting about saliva cortisol, but don't know the reason why it isn't a good test, do you have an idea ?

I sent you a pm, check it please, if you don't want to deal with those questions just tell me clearly so I can go on and discuss them with other people.

Thanks

 

[RedStaR]

DO you understand that I gave both to people/ And also fluconazole does this all better. For Recurrent Cushing's, Fluconazole Found to be Safe Alternative in Case Report


You need to understand that all you do now with keto, estro , is go back to finasteride body chemistry.

when you take finasteride. your estrogen is high. ( receptors downregulates) cortisol is low , and DHT is low

Keto plus estro puts you in this body chemistry again.

Keto works because it was shown to restore GR after some time, not because it downregulates cortisol production. You have glucocorticoid insufficiency with PFS. Cushing is the opposite. Forget libido and sex without cortisol.

Estrogen makes the GR and PR sensitive again, serotonin is the same. Which is why estrogen and serotonin are stress hormones. Estrogen or phytoestrogens will restore GR function.

Lastly, keto is a PXR antagonist, which will also restore it's function after a long time of chronic activation from cortisol, progesterone, estrogen, testosterone, and finasteride, all potent activators of PXR.

Restoring thyroid hormones will make you better, but if you only do it through medicine, it is not a fix.

 

[Helen]

Keto works because it was shown to restore GR after some time, not because it downregulates cortisol production. You have glucocorticoid insufficiency with PFS. Cushing is the opposite.

Estrogen makes the GR and PR sensitive again, serotonin is the same. Which is why estrogen and serotonin are stress hormones. Estrogen or phytoestrogens will restore GR function.

Lastly, keto is a PXR antagonist, which will also restore it's function after a long time of chronic activation from cortisol, progesterone, estrogen, testosterone, and finasteride, all potent activators of PXR.

Dude, you think I dont know how Keto works? It restores GR sensitivity since it blocks the receptor and lowers CORTISOL axis to zero))) since it kills 450 enzymes)) including testosterone)) and cholesterol conversions))




YOU have high estrogen when you take finasteride.))) while on finasteride your ESTROGEN goes up.

estrogens and phytoestrogens are 2 different things.


As I told you already like 2 times. we were taking imidazoles, and ketoconazole. People with high cortisol benefited from it WHILE on it.

When they went off , everything came back and in some cases even worse.


When you take ketoconazole plus estrogen. you inhibit the axis, so test goes down, you take estrogen, and you have low cortisol

YOU get into exactly finasteride body chemistry. Low DHT, high estrogen, and low axis( since finasteride KILLS progesterone when you take it)



We have many cases here, what is good for one case, bad for another

 

[RedStaR]

Dude, you think I dont know how Keto works? It restores GR sensitivity since it blocks the receptor and lowers CORTISOL axis to zero))) since it kills 450 enzymes)) including testosterone)) and cholesterol conversions))




YOU have high estrogen when you take finasteride.))) while on finasteride your ESTROGEN goes up.

estrogens and phytoestrogens are 2 different things.


As I told you already like 2 times. we were taking imidazoles, and ketoconazole. People with high cortisol benefited from it WHILE on it.

When they went , everything came back and in some cases even worse.


When you take ketoconazole plus estrogen. you inhibit the axis, so test goes down, you take estrogen, and you have low cortisol

YOU get into exactly finasteride body chemistry. Low DHT, high estrogen, and low axis( since finasteride KILLS progesterone when you take it)

Yes, and off finasteride, your cortisol and estrogen go down. Your PXR is not working properly because it works through GR. You don't have cortisol for proper signalling, and estrogen goes down reducing the signalling even more. Restoring GR function is one of the first steps in restoring homeostasis.

 

[Helen]

Yes, and off finasteride, your cortisol and estrogen go down. Your PXR is not working properly because it works through GR. You don't have cortisol for proper signalling, and estrogen goes down reducing the signalling even more. Restoring GR function is one of the first steps in restoring homeostasis.

One more time for you , we have 2 cases here. I came up with the theory of GR receptor. this is how this forum has started.

I tried many things on people.

On ketoconazole your cortisol GOES WAY DOWN)))) and people feel recovered while on it and then when they come off everything comes back and sometimes worse than before. For some cases.



other people feel good on cortisol supplements. and some feel great and recovered when you block cortisol receptor.totally ( they feel recovered in this moment)


And post FIN your estrogen does not go down, and your cortisol also does not go down, where do you get that, Only in half cases.


On finasteride rogesterone goes to zero, just test it , take fin and measure)), and your estrogen is high ))) Body gets used to living in this body chemistry

this is why if you take fin again, you feel recovered.

exact the body chemistry you will get if you go on keto plus estro))

 

[RebelWithACause]

I quit finasteride twice (like 4-5 months before having "crash") and used Arimistane (androsta-3,5-diene-7,17-Dione) at that 1st time while getting off. I think I recovered pretty quick back then. Freaked out because I started losing my hair very rapidly and went back on finasteride. I was off only for 4-5 days but remember every day getting better. Not sure if I would of crashed anyways.

Maybe this was from cortisol blocking effect? I remember reading bloodwork from a guy and he said it had 0% effect on estrogen but his cortisol was a lot lower.

 

[Helen]

@RedStaR I ' m not arguing with you about GR receptor at all . As you can read that it is the theory we proposed here, and what I have been telling you specifically last time we spoke

Now for some reason you are talking my words to me ))

question is upregulated or downregulated GR)) and cases.

Plus upregulated or downregulated AR.


As I told you folks who felt good on ketoconazole, did not get cured. Sat on this shit for 10 months))

Dude, has to sit on keto always to feel the effects

This is why I'm telling you about 2 cases.


I hope you understand that 2 only documented cases that we had with 3 adiol levels, and all tests that got cured from hormones., were on LETRO and DEXA)) on letro the guy documented it , did all the testing and checked even 3 adiol levels before and after LOL

The guys cycled letro and restored his estrogen sensitivity , this then regulated his PAM peptide back to normal. and Pacap and all other crap restored its functions.

 

[Helen]

I quit finasteride twice (like 4-5 months before having "crash") and used Arimistane (androsta-3,5-diene-7,17-Dione) at that 1st time while getting off. I think I recovered pretty quick back then. Freaked out because I started losing my hair very rapidly and went back on finasteride. I was off only for 4-5 days but remember every day getting better. Not sure if I would of crashed anyways.

Maybe this was from cortisol blocking effect? I remember reading bloodwork from a guy and he said it had 0% effect on estrogen but his cortisol was a lot lower.

you dont lose hair on cortisol blocking things. Ketoconazole grows hair)) since it kills DHT)) and all axis.

 

[talkingant]

I have low cortisol on blood tests (PSSD). I took prednisone a few yrs ago and dont remember anything interesting about it. I also did an Anavar cycle recently and didnt see much effect. But I do think cortisol is likely dysregulated in PFS/PSSD/PAS. Question is, how do we permanently upregulate or downregulate cortisol in these cases, in a safe way.

Regarding TEI, I would love to jump back on it. But the main problem for me was it seemed to cause insomnia. I’m already a difficult sleeper and am very careful about managing my sleep so I dont fuck it up. But when on TEI I just couldnt stay asleep for as long. After a few weeks of TEI, I was exhausted, which made it hard to do my other life obligations. I might give it another go in a few months, but I would need some extra motivation to stick through it. I think it would help if we could compile the results of members' TEI trials on the wiki. If I could quickly read up on a number of TEI success stories, it would help motivate me to try TEI for longer cycles.

 

[Helen]

I have low cortisol on blood tests (PSSD). I took prednisone a few yrs ago and dont remember anything interesting about it. I also did an Anavar cycle recently and didnt see much effect. But I do think cortisol is likely dysregulated in PFS/PSSD/PAS. Question is, how do we permanently upregulate or downregulate cortisol in these cases, in a safe way.

Regarding TEI, I would love to jump back on it. But the main problem for me was it seemed to cause insomnia. I’m already a difficult sleeper and am very careful about managing my sleep so I dont fuck it up. But when on TEI I just couldnt stay asleep for as long. After a few weeks of TEI, I was exhausted, which made it hard to do my other life obligations. I might give it another go in a few months, but I would need some extra motivation to stick through it. I think it would help if we could compile the results of members' TEI trials on the wiki. If I could quickly read up on a number of TEI success stories, it would help motivate me to try TEI for longer cycles.

because it is fixing you . it is killing your serotonin to restore its function. Thus no sleep

Plus it is chelating copper which causes insomnia.

 

[RebelWithACause]

I'ma do this first cycle for 2 months and then re-test and start second cycle for 3 months in new year. I have ups and downs. I also feel tired on a lot of days but I sleep like a baby. I do wake up a bit earlier than usual. In beginning (1st week) I had some insomnia. Sometimes I get a bit uptight and aggressive on TEI. The feeling like you want to punch someone in the face. I don't have a lot of tolerance for people in general at the moment. I just focus on my own things. I do get a lot of shit done ATM.

So TEI has good and bad things while on it. For me it is definitely do able. Sometimes I feel bad and get a bit paranoid "Will it work? - What if it is bullshit?" etc. But then 2 hours later I feel normal again.

 

[RedStaR]

@RedStaR I ' m not arguing with you about GR receptor at all . As you can read that is the theory we proposed here, and what I have been telling you specifically.

question is upregulated or downregulated GR)) and cases.

There is no upregulated GR function. Cortisol levels mean nothing for determining GR function. Restoring GR sensitivity can take months on a GR antagonist, and it might not always work. The hormone levels might be high or low in different people with the same symptoms because the body tries to work around what your body's current hormonal state tends towards, and what would it take to survive through the most basic homeostasis. Low cortisol or high cortisol with GR resistance means different states with the same pathology and the same route to a cure. The body is trying to retain potassium in one, but not the other, which is an MR issue. It might be that GR is functioning normally on the HPTA feedback, but not for the nervous system. Inhibiting GRb, restoring GRa, PPRAa, restoring PXR resistance which is now allowing NF-kb to run wild and repress GR expression, ingesting safe levels of mold, overtraining, estrogens, phytoestrogens, vitamin D, there is a ton of research out there that interacts with the genes transcribing these receptors.

 

[RedStaR]

Look, get some shredded Parmesan cheese, leave it out at room temperature in a clean space, eat the moldy cheese after a few days. If you feel better, then report back.

 

[Helen]

Look, get some shredded Parmesan cheese, leave it out at room temperature in a clean space, eat the moldy cheese after a few days. If you feel better, then report back.

People feel better and worse on 100 gazillion things ))

 

[Helen]

There is no upregulated GR function. Cortisol levels mean nothing for determining GR function. Restoring GR sensitivity can take months on a GR antagonist, and it might not always work. The hormone levels might be high or low in different people with the same symptoms because the body tries to work around what your body's current hormonal state tends towards, and what would it take to survive through the most basic homeostasis. Low cortisol or high cortisol with GR resistance means different states with the same pathology and the same route to a cure. The body is trying to retain potassium in one, but not the other, which is an MR issue. It might be that GR is functioning normally on the HPTA feedback, but not for the nervous system. Inhibiting GRb, restoring GRa, PPRAa, restoring PXR resistance which is now allowing NF-kb to run wild and repress GR expression, ingesting safe levels of mold, overtraining, estrogens, phytoestrogens, vitamin D, there is a ton of research out there that interacts with the genes transcribing these receptors.

People are and were on keto for years and 10 months))) We have been taking fluco and keto for years )))

Only 2 documented cases where people got rid of PFS with hormones, were from dexa and Letro( the person blocked estrogen) and stay on it for 5 months))

This upregulated estrogen receptor back)) Since fin downregulated it))


Dont confuse phytoestrogens and estrogens)) Phytoestrogens like clomid blocks the action of estrogen

 

[Helen]

@RedStaR I have a study which studied SSRIs and showed upregulated GR. in some cases and downregulated in others.

If a person feels good when he kills cortisol( and cortisol was not working, he should feel like shit ))) but a person takes a cortisol blocker. like Tubzy did, or other people whoever took RU, and they feel cured while ON IT, not when they get off of it))

WE have 2 cases, one cases feels totally cured when they block cortisol receptor. In THAT moment

 

[Helen]

@RedStaR I agree that GR is the main culpit in some people. And restoring GR is the main idea. And has been. you sound like you just came up with it))

I kept telling you this last time we spoke. and now you jut repeat. it But I have to cover all basis here.

and I look at what restored people before.

I am sure ketoconazole and fluconazole and all other CYP inihbitors. can help some cases

We discussed this many times.

 

[SwaZ]

Look, get some shredded Parmesan cheese, leave it out at room temperature in a clean space, eat the moldy cheese after a few days. If you feel better, then report back.

May i ask what the moldy cheese would do?

 

[MNK99]

make sick.
also smells bad and is gross. and ridiculous.

 

[MNK99]

--They're clearly not trying to cure shyt. Maybe that's harsh. But 100k? That's like 1/10th of a shitty apartment on east coast.
--You could raise >>>>>>> 100k with fake financials alone (not that I condone this). You can make a ridiculous project and fund that or research underwater basket weaving at a liberal arts college and raise more than 100k. You could ace a test and get a >100k scholarship.
-BUT 100k to cure A LOT of people? Come on.
-And *yeah yeah, but what are you trying to do to fix it all? I'm fixing myself - the rest of life, and give good advice at times. ---I commend them for their efforts tho.
-Seems like a joke. -I'm cynical tho. --I mean where's the cure for all the rest? There's no cure for life where things happen.
-I am optimistic that I've gotten like 1000x better and so have many others; but some cure means what... they'll develop a drug? --- It's like medical cannabis clinics, people (old) are all like everyone will be stoned now... but they don't get that literally every single college student (I mean say 60-80%) has tried/ and dealers existed and have better stuff for most people (stoners) anyways.
---Sativex.. is a crappy medicine (medical cannabis) and so are many of the legal dispensary clinics. So even if they "cured" PFS or PSSD. What is it? A drug that works for 20% of people and leaves them fucked up in a multitude of other ways? I'll read it. I did like 2 years ago skim it, I'll read it tho*.