Astral kid
Member
- Messages
- 40
Nice thanks for clarifying
POTENTIAL explanation for PFS.
- Thread starter Helen
- Start date
JasonSky
Well-Known Member
- Messages
- 133
I'm not Helen either, but I also would suggest Tei. The electrolytes protocol was more of a generic health protocol for balancing the body, TEI provides a much more streamlined service for your own body chemistry. I was actually about to order a hairtest myself.
@Boris Do you know or anyone else know the best way to order one? Is It through emailing Catherine? Or some other websites people have linked?
- Messages
- 2,590
getting the test is the easiest through catherine, you just fill out the form and email it back to her. If you want to buy the program/supplements, you can go through her or if you want there are other sites that some members listed too, either way is fine. You just have to manually select the stuff you need on the other sites for the supps
talkingant
Well-Known Member
- Messages
- 125
Good article on UDP-glucuronosyltransferase enzymes (UGT), with this diagram:
There are many types of UGT enzymes. It looks like UGT2B17 is most important in 3a-diol-G production.
Red wine and component flavonoids inhibit UGT2B17in vitro.
In prostate cancer cells, bile acids and androsterone, which activate the FXR receptor, reduce activity of UGT2B17. Could be the same in normal cells.
AR activation by DHT downregulates UGT2B17 in prostate cancer cells.
Androgen deprivation therapy upregulated UGT enzymes. AR antagonist bicalutamide increased UGT2B17 levels within 48 hours in vitro.
If AR is overexpressed in PFS, and AR activation downregulates UGT enzymes, then PFS people should have low 3a-diol G levels due to UGT downregulation.
UGT2B17 gene has a common deletion polymorphism which results in less enzyme activity- could be genetic marker for susceptibility to PFS. 23andMe does not test for these SNPs unfortunately.
There are many types of UGT enzymes. It looks like UGT2B17 is most important in 3a-diol-G production.
Red wine and component flavonoids inhibit UGT2B17in vitro.
In prostate cancer cells, bile acids and androsterone, which activate the FXR receptor, reduce activity of UGT2B17. Could be the same in normal cells.
AR activation by DHT downregulates UGT2B17 in prostate cancer cells.
Androgen deprivation therapy upregulated UGT enzymes. AR antagonist bicalutamide increased UGT2B17 levels within 48 hours in vitro.
If AR is overexpressed in PFS, and AR activation downregulates UGT enzymes, then PFS people should have low 3a-diol G levels due to UGT downregulation.
UGT2B17 gene has a common deletion polymorphism which results in less enzyme activity- could be genetic marker for susceptibility to PFS. 23andMe does not test for these SNPs unfortunately.
Last edited:
- Messages
- 5,415
propeciahelp has a ton of tests of 3a-diol G with low readings
And FInasteride studies found 3a-adiol HIGH in PFS patients
We need to consider that may be there is a lack of substrate for all these enzymes, or high beta glucuronidase which basically destroys glucuronic acid bonds.
So it is not only only UGT2B12 effected but all of them.
Last edited:
Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women. - PubMed - NCBI
DHEA increases 3a-diol G four fold in this study (with females.) Do PFS generally have low or high DHEA (and DHEA-S?)
It is known that alcohol increases DHEA-S. On thanksgiving I drank myself into complete blackout and have had the highest libido and highest EQ in years. It hasn’t gone away. Very strange.
DHEA increases 3a-diol G four fold in this study (with females.) Do PFS generally have low or high DHEA (and DHEA-S?)
It is known that alcohol increases DHEA-S. On thanksgiving I drank myself into complete blackout and have had the highest libido and highest EQ in years. It hasn’t gone away. Very strange.
Last edited:
If it’s all of them, how do we sort that out? Nothing jumps to mind immediately.
RebelWithACause
Well-Known Member
- Messages
- 2,620
RebelWithACause
Well-Known Member
- Messages
- 2,620
Some info:
Jeepers, it’s all TEI now! Am I the only one here doing ARL?
RebelWithACause
Well-Known Member
- Messages
- 2,620
ARL is good too just takes a bit longer and can be harder mentally. Admiral is also doing ARL.
@Helen this topic has been discussed before
23andme & Chronic insomnia and family history of psychiatric/CNS disorders
23andme & Chronic insomnia and family history of psychiatric/CNS disorders
- Messages
- 2,590
They both work just ARL takes longer. Also people here like goose have been on TEI way longer than anyone on ARL and he is almost cured so from a log standpoint TEI is more credible as of now. @Helen seems to like TEI since it does not contain methylated vitamins as well
- Messages
- 5,415
Yes this guy got it correctly . this is basically electrolytes protocol
the only thing he started to do crazy stuff later on. and basically went on benzos))
I hope you understand now, that it is important to take the whole protocol for a while to get rid of fin. whether you follow electrolytes protocol Cdnuts protocol, TEI
Look how @Orion is doing it . He is doing everything in it < fasting , liver flushes, all supps. and he wont have a bit of any bs left in his system
Liver flushes alone got rid of about 50% of my problems in me. Just liver flushes
Last edited:
- Messages
- 2,821
Immune system can be overactive / unbalanced. Balancing TH1/ TH2 can help this and that’s why urine really caught my attention.
Any food sensitivities, allergies? Same thing.