ZINC FINGER THEORY DISCUSSION for PFS - 2 cases

[Canari]

when I’m taking a tbsp of ACV with honey every morning. Is there an equivalent of this that you would recommend, since you are against acv?

Lemon juice?

I know the mix lemon honey for canker sores for example.

 

[snowball]

Where are you guys buying L-Histadine in Canada? Is bulk supplements the only source?

 

[Helen]

Histaminergic Regulation of Pancreatic β-Cell Replication and Insulin Secretion, Biochemical and Biophysical Research Communications | DeepDyve

SO it looks like histidine is what causes insulin to rise.

SO this probably could be the way to see cases. Low and high insulin?


We had tons of people with very low insulin levels in PFS. And this makes sense. Cortisol is not sensitive since no histidine. insulin is lowered on purpose since cortisol can't do its job and also thyroid is switched off

I guess some with high insulin can have a different imbalance. and more cysteine problem. But I also read couple of very good studies that said if histidine substituted with aspartic acid in insulin. then it can cause hyperinsulinemia . So not very clear.

It would be amazing if people tested their insulin levels along with their histidine levels

 

[Helen]

Effects of carnosine on insulin and glucagon secretion in the dog - ScienceDirect here is the explanation for those why insulin goes up also after eating protein.

 

[Helen]

@JonnyCraig

Here are your connections.
http://www.physiology.org/doi/10.1152/ajpcell.1999.277.4.C605

Involvement of histidine residues and sulfhydryl groups in the function of the biotin transport carrier of rabbit intestinal brush-border membrane - ScienceDirect


histidine is involved in biotin transport from the intestine.

 

[Canari]

Cortisol is not sensitive since no histidine.
insulin is lowered on purpose since cortisol can't do its job
and also thyroid is switched off

Looks like me.
- Slow 1 = low thyroid -
- Since fasting I do not have to eat all day = shows problem with cortisol
- my blood sugar is always on the highest of the normal range = I seem to have low insuline (since long, as I had got a glucose tolerance test and glucose was going down slow)

I go on with acids and high protein meals.

I have noticed a new taste for coliflower and onions, rich in sulfur... does it indicate something special?

 

[JonnyCraig]

Interesting stuff, seems like we are on the right path..

"In a paper regarding evidence based guidelines in the treatment of alopecia for both women and men (Blumeyer et al.), various amino acids are mentioned with a special mention for cysteine. Cysteine is considered to be one of the main factors involved in hair growth.

The group that also followed the dietary supplement had a 50% increase in hair growth.

The paper cites a study (Morganti et al.) where there was a significant mean change of total hair count in both male and female patients after a treatment containing cysteine.
The participants had to take an oral supplement that contained cysteine, copper, zinc and histidine 4 times a day for 50 weeks and the treatment group had remarkable results with their anagen rate."

"The amount of cysteine in a hair fibre is an indicator of the hairs health. (J Cell Biol. 1990) In various animals, cysteine, along with other amino-acids and proteins, can protect hair and feathers and help them establish mechanical resilience. (Strasser et al., 2015)"

"Another study suggests that l-cysteine prevents the reduction in keratin synthesis induced by iron deficiency in human keratinocytes. It seems that l-cysteine promotes an important up regulation of keratins expression in the de novo protein synthesis and it counteracts the adverse effect of iron deficiency in keratin expression. (Miniaci et al., 2016)"

"The groups of mice received three dose levels of l-cysteine and vitamin B6 daily. Vitamin B6 was used due to its important role in incorporating l-cysteine in hair cells. After 6 months of exposure, the results showed that mice receiving the most l-cysteine/vitamin B6 doses had less hair loss, concluding that oral administration of vitamin B6 and l-cysteine may be an effective preventive treatment in alopecia. (D’Agostini et al., 2007)"

 

[TubZy]

Interesting stuff, seems like we are on the right path..

"In a paper regarding evidence based guidelines in the treatment of alopecia for both women and men (Blumeyer et al.), various amino acids are mentioned with a special mention for cysteine. Cysteine is considered to be one of the main factors involved in hair growth.

The group that also followed the dietary supplement had a 50% increase in hair growth.

The paper cites a study (Morganti et al.) where there was a significant mean change of total hair count in both male and female patients after a treatment containing cysteine.
The participants had to take an oral supplement that contained cysteine, copper, zinc and histidine 4 times a day for 50 weeks and the treatment group had remarkable results with their anagen rate."

"The amount of cysteine in a hair fibre is an indicator of the hairs health. (J Cell Biol. 1990) In various animals, cysteine, along with other amino-acids and proteins, can protect hair and feathers and help them establish mechanical resilience. (Strasser et al., 2015)"

"Another study suggests that l-cysteine prevents the reduction in keratin synthesis induced by iron deficiency in human keratinocytes. It seems that l-cysteine promotes an important up regulation of keratins expression in the de novo protein synthesis and it counteracts the adverse effect of iron deficiency in keratin expression. (Miniaci et al., 2016)"

"The groups of mice received three dose levels of l-cysteine and vitamin B6 daily. Vitamin B6 was used due to its important role in incorporating l-cysteine in hair cells. After 6 months of exposure, the results showed that mice receiving the most l-cysteine/vitamin B6 doses had less hair loss, concluding that oral administration of vitamin B6 and l-cysteine may be an effective preventive treatment in alopecia. (D’Agostini et al., 2007)"

Someone needs to try topical cysteine. Maybe with B6 too. There was a few people who had results with b6 and zinc sulfate topically (I posted some logs before), but @JonnyCraig repost this into the experimental hair thread too, so some people start trying it

 

[JonnyCraig]

Someone needs to try topical cysteine. Maybe with B6 too. There was a few people who had results with b6 and zinc sulfate topically (I posted some logs before), but @JonnyCraig repost this into the experimental hair thread too, so some people start trying it

Done, but what is your thing with always wanting to try topically? You think the results will be superior?

 

[TubZy]

Done, but what is your thing with always wanting to try topically? You think the results will be superior?

Well in this instance, we could probably verify how well it works since topically basically all of it would be absorbed locally rather than orally getting distributed throughout the body first.

 

[JonnyCraig]

These look like interesting products, should be available to anyone in North America and abroad even:

Source Naturals, Amino Day, 1,000 mg, 120 Tablets

Source Naturals, Amino Athlete, 1000 mg, 100 Tablets

I think the first one may be better for our purposes, I could be wrong, wish we could see the dosages.

I don't like that they are prop blends though, so we can't see the exact dosages.

I wonder if it would be best to buy and use a product like these above, alongside with the extra Histidine, etc, to avoid any imbalances (and fix any that we may not know about).

 

[Helen]

Well in this instance, we could probably verify how well it works since topically basically all of it would be absorbed locally rather than orally getting distributed throughout the body first.

It is all about balance. In my case. cysteine and methionine caused terrible hairloss. and histamine reactions. B6 will only work when there is enough histidine. Since histidine is broken down by b6 and if you force b6 with active forms. you will get histamine .

As you saw from amino acid profiles with androgenic hairloss. Cysteine is missing in only 50% cases.

CDO controls biotin transport from the intestine. So all this topical application stuff is irrelavant. it is not about cysteine in hair, it is about cysteine and histidine controling biotin uptake by activating CDO.

When I outlined zinc finger , I accounted for all of this. It has everything needed in there. Folate, histidine alanine. etc. Don't know why you are trying to change the protocol which is already outlined by taking some ghetto protocols which will screw you up in other things.

To get to cysteine you need serine in the body plus magnesium plus b6, you cant just keep taking cysteine it is not good. You need to restore digestion so your body restores everything. For that you need to take the protocol not some parts of it. . Since if you have high cysteine levels it will cause cancer. and 50/50 people have high cysteine. And another 50 have low serine , thus low cysteine.

NO need to look, just try around the original zinc finger. Every little part of it is needed. You can take 1/2 of the protocol, or 1/8 of the protocol. It can all fall apart if you don't take it all.

the only person who is taking it all is SEVENS , they guy who took Deca. He is taking zinc copper also, And he does not have a libido crash from them. Since he is taking all the things.

I know it is hard to understand and it is easier to take some shortened route and stuff.

But you have to understrand, it is not about fixing hairloss, it is about balancing yourself.

You take cysteine, you fix hairloss, and then you get a heart attack from high homocysteine levels. How good is it

I urge people to get tested first , really, and see exactly where there problem is . BUT even if you find your problem, and you are fixing it , in a while you will go onto another side of this problem, if you are not going to feed balanced route.


IN any case @TubZy I am for experimenting with different parts of zinc finger. Just keep this POST in mind. Since eventually no matter what route you take, you will have to come back and take everything, since you will be getting imbalanced on some other part. Like fix hairloss, lose libido, fix hairloss get diabetes.

This is why we have to be careful.

 

[Helen]

ALSO @TubZy Don't forget that we don't know how those tests are done for amino acids, and we don't know what they mean.

May be it means that we need to take in the amino acids which are not MISSING on that profile, to put those which are missing in balance.

that is also a possiblity that we should not forget.

As I mentioned before zinc finger could be upregulated also.

 

[Helen]

Interesting thread.

Supplements

 

[Helen]

Seeing Good Things With Histidine - AutismWeb Forum

Look at this woman. histidine plus copper= say good bye AUTISM

 

[mattyb]

gbold - is this one of the papers you've read?

[Treatment of experimental metabolic alkalosis by sorbamine]. - PubMed - NCBI

 

[Helen]

gbold - is this one of the papers you've read?

[Treatment of experimental metabolic alkalosis by sorbamine]. - PubMed - NCBI

Yeah \I read this one also. I think it is one of the studies I read before I put accent on those 3( I put them highlighted in BOLD in the protocol , since they are base aminos.

it is no wonder, those are 3 amino acids, which need HCL. You force them in, body has to reorganize.

It seem cool right? Easy way out for alkalosis.

 

[HerrFisch]

Any idea how the "beta alanine rush" is in connection with histamine or histidine levels?

I did get this "skin rash" pretty fast and easy with dosages as little as 2g in the past.

 

[Helen]

Any idea how the "beta alanine rush" is in connection with histamine or histidine levels?

I did get this "skin rash" pretty fast and easy with dosages as little as 2g in the past.

I guess it binds histidine.

 

[HerrFisch]

I guess it binds histidine.

Yes. But for example, my friend could take 7g with no reaction and I took 2g with rash all over my back, face, hands. Similar with niacin flush. And he has several allergys. I got none.

I have high histamine levels. Maybe its in connection with that. Or because of high or low levels of histidine? Would be interesting to know