Dr. Goldstein Research Study (PSSD/PFS)

[Ghost]

Hi all.

I've visited Dr. Goldstein in San Diego recently, and he was very excited to hear that I run the PSSD forum, and that I'm active on the online communities. As others have said, he is an amazing person and doctor. He believes in PSSD, and has seen a fair number of cases in the past. There is a presentation that he gives to every patient. I know that not everyone here is going to be able to meet with Dr. Goldstein, so I can answer any questions about what he does. The physical exam might be one of the most important parts, but it's not the entire visit. He hopes for greater PSSD awareness and gave me a few copies of his book: “The Potent Male”. He wants me to give them to anyone who is interested.

The other thing is the scans that he does. I suggest that more people go to Goldstein because he does scanning. What is he scanning for? Scarring on the penis. A lot of PFS and PSSD people have it. I have it. It scares me that I have penis scarring, but Goldstein has a treatment that often reverses it (he showed me the before and after scans). However, it is an option if you go see him, and I have started on this treatment protocol. He says that a few PSSD and PFS patients have seen great success on it. I recommend that everyone who can afford to see Dr. Goldstein should. He is the leading expert in the sexual medicine field, and the more people with PSSD he sees, the more he will learn.


HERE IS THE MOST CRITICAL PART:

HE WANTS TO DO A STUDY. He was VERY excited that I might be able to raise funds for this study. He already has a PhD researcher who he is working with, and can immediately begin working on a grant proposal. If there is ANYONE who could donate a large portion of this study, please do not hesitate to inform me. Dr. Goldstein is world-renowned and this might be a one-time opportunity. He is entering the last phase of his career, and I don't know of any other person who is as qualified to run this study as Dr. Goldstein. The premise of the study is looking at the damages caused by SSRI exposure. If people are interested in funding this, we could get it started very quickly.

 

[Shanks]

Ofc interested how much do they need for this study?

I'm from Germany so i can't visit him. But could you plz tell me a bit about his treatment. And what he is thinking what causes PSSD?

 

[Ghost]

It's a $250,000 study with all costs. The problem is that's a lot of money. The good news is that if we combine from the PFS and PSSD communities, we might have a better chance of funding. I know that there are a lot of people on these boards, and then SO MANY more who are just lurkers and never visit. This would be the time for them to help out if they could. There HAS to be some very rich people with PSSD and PFS. Dr. Goldstein is very professional, so the money would all go directly to him and he really cares about this stuff.

 

[Ghost]

Ofc interested how much do they need for this study?

I'm from Germany so i can't visit him. But could you plz tell me a bit about his treatment. And what he is thinking what causes PSSD?

The treatment is called "PRP". It's a fairly common procedure for other injuries, but it involves needles and painkillers, and it's your dick... So you'd need to find someone very very qualified to do it.

 

[Shanks]

By PRP you mean u gonna inject your own (blood)Plasma in your dick?

 

[B_D_Acc]

That's awesome news man. You should definitely look to crowdfund some of it, even if people can only afford small donations. If he can show that hundreds of people have already donated their own money to support the research that'll really encourage the grant boards to cover the rest.

 

[Shadow]

I will be honest with you @Ghost, I dont think much would end up of a study with this focus.

The premise of the study is looking at the damages caused by SSRI exposure.

I think that the possible damage(penis scarring) is a secondary effect.

As @Area-1255 said in PSSDForum: we are forgetting that the problem appear AFTER stopping the drug. Add this to the fact that one pill is enough to trigger the problem and we can lower the possibilities of some things like, epigenetic change, damage, depletion of something.

Every study that could be done about PSSD is important, but we know that our problem occurs at CNS level. This is why I think that Melcangi is in the right track.

 

[Ghost]

By PRP you mean u gonna inject your own (blood)Plasma in your ****?

Yep, that's the treatment that's been working for people so far lol

 

[Ghost]

I will be honest with you @Ghost, I dont think much would end up of a study with this focus.

The premise of the study is looking at the damages caused by SSRI exposure.

I think that the possible damage(penis scarring) is a secondary effect.

As @Area-1255 said in PSSDForum: we are forgetting that the problem appear AFTER stopping the drug. Add this to the fact that one pill is enough to trigger the problem and we can lower the possibilities of some things like, epigenetic change, damage, depletion of something.

Every study that could be done about PSSD is important, but we know that our problem occurs at CNS level. This is why I think that Melcangi is in the right track.

I've been talking to him more and he realizes it's more than just the physical damages. TBH I think it's a mix of damage from lack of blood flow and then also from ROS. I don't think it's directly from the SSRI itself, becuase not everyone on an SSRI (I don't think at least) gets this scarring. You know what increases ROS production? Serotonin.

http://www.goldjournal.net/article/S0090-4295(13)00957-6/fulltext
Episodic spinal serotonin receptor activation elicits long‐lasting phrenic motor facilitation by an NADPH oxidase‐dependent mechanism

 

[expendable]

I've been talking to him more and he realizes it's more than just the physical damages. TBH I think it's a mix of damage from lack of blood flow and then also from ROS. I don't think it's directly from the SSRI itself, becuase not everyone on an SSRI (I don't think at least) gets this scarring. You know what increases ROS production? Serotonin.

Ghost can you tell me what ROS is? For the record, my only symptom left is diminished sexual sensitivity- my dick isn't physically numb or anything, just somewhat sexually numbed. Everything else has recovered. Is this consistent with anything?

 

[Ghost]

Reactive Oxygen Species: Reactive oxygen species - Wikipedia

I'd say check your pelvic floor. That could be doing it. However, as you know, this might not be it. That's just the easy answer, and worth it to check out.

Otherwise it might be a dopamine problem, or a nerve problem. If all else has recovered, it's a bit odd how only that symptom remains.

 

[Canari]

The premise of the study is looking at the damages caused by SSRI exposure.

Look at the damage? Very nice for a researcher, but this has nothing to do with the cure, and those who suffer know there is damage... Or is this needed so that official medicine takes post drug syndroms in account? Sad, but if this is needed....

we know that our problem occurs at CNS level.

he realizes it's more than just the physical damages.

Sorry to insist, but the CNS does not include the ANS, and the ANS is very concerned by all that is treated by SSRI...
+ when you take a drug that affects your health, there is an obvious response of the body in the fight and flight range.

When you talk about acethylcholine or noradrenaline, consider that these are released by ANS nerves.

 

[Ailaeshiz]

I agree @Shadow I think the scarring is a secondary effect.

 

[Ailaeshiz]

He says that a few PSSD and PFS patients have seen great success on it.

What's his success rate so far? If it's more than 50% of his patients I'd definitely be interested in hearing more.

 

[Shadow]

I've been talking to him more and he realizes it's more than just the physical damages. TBH I think it's a mix of damage from lack of blood flow and then also from ROS. I don't think it's directly from the SSRI itself, becuase not everyone on an SSRI (I don't think at least) gets this scarring. You know what increases ROS production? Serotonin.

http://www.goldjournal.net/article/S0090-4295(13)00957-6/fulltext
Episodic spinal serotonin receptor activation elicits long‐lasting phrenic motor facilitation by an NADPH oxidase‐dependent mechanism

I linked to you this escitalopram article a couple of times lol

I dindnt knew that serotonin increases ROS, very interesting

 

[Ghost]

@Canari you're right that this study isn't the cure, but from a scientific perspective he can't really look for a cure until he finds out what's going wrong. The bigger thing that I'm worried about is that such a small percentage of people get PSSD/PFS, so how do you get enough animals to have it in a study? I think it's from giving them drugs early. That works in PSSD with mice I know.

@Ailaeshiz I don't know. I can ask him that. Sample size is small I think.

 

[Canari]

until he finds out what's going wrong. The bigger thing that I'm worried about is that such a small percentage of people get PSSD/PFS,

So it is not to find out that the syndrome exists, but to find out why some people get it? And find what is the process involved?

I don't know what "drug given early" you are talking about, but I would bet that the ANS is involved, and almost for sure with what is called peri-natal trauma, as this pre-disposes to getting more shock afterward and having less resilience.

As I have had some, I can often recognize people who lived this too, and it does not mean early adverse childhood but mostly shocks between conception and 6 months of age. I remember once telling somebody to ask his mother about a type of accident during pregnancy, and he said he did not have to ask and told me about something that he knew about but would not have imagined important. Then to a father who told me the birlth problem of his daughter, I asked if she was "like this or like that" and he was amazed I described her without ever seeing her. Then a lot of panic attacks come from having surgery during infancy, and being anesthetized during a moment of fear. So it is not only about early shock. Nobody knows what special type of accident gives what, because this is imprevisible due to the multitude of parameters that get added to provoque a "butterfly effect".

 

[Ghost]

I think it's to see what's wrong first of all, and then later on to see how to fix it.

I just mean that there are studies where researchers give young mice and rats SSRIs and they never regain normal sexual function unless they are later given a) more SSRIs as adults, or b) estrogen and DHT. If you give adult mice or rats SSRIs, a vast majority wouldn't get PSSD (far under the 5% level of statistical significance). This means that in the eyes of a researcher or science, PSSD or PFS don't really statistically occur. You're never going to get the percentage of people with PSSD/PFS to reach any level of statistical significance because they are so rare.

 

[Canari]

You're never going to get the percentage of people with PSSD/PFS to reach any level of statistical significance because they are so rare.

But when you are the one... bingo
5% is still big enough to be of concern and be written big in the warnings of the drug! How dismissive or really warning are those side effect warnings?

 

[Canari]

Interestimg point of view about CNS, and when there is something wrong, then the ANS also activates. He is right to say that psychiatrists were the only specialist working without looking at the organ they are concerned by!