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Ssri’s are 5ht1a antagonists generally so you are oversimplifying things.

Plus not all “commercial publications aka bro science websites” make a distinction between pre-post synaptic receptors

Imipramine obviously

Wonder if low dose cycling would be an option here

You are one of the few with retrogade ejaculation, which makes me wonder if you are standard pssd in the first place. Yes tca’s cause sexual side effects, most of them at least. Its about receptor profile in this case, not about a group. Im all for trying things, but slow and steady. Not full...

@zadig777 so going to try imipramine then? Im still reading about it to understand it better and check similar profiles why this would work while others failed

The article is rather weak in the sense that they only look at the effect while ON imipramine, and offer no real explanation why the effect occured.(Only in a 2006 article on citalopram, not why it PARTLY reverses).

Cypro is quite nasty, so im trying to avoid that. Jury isnt out of Tianeptine is a proper SSRE. @Area-1255 had a nice overview of herbs to decrease serotonin, but its kinda hard to find atm

Ella/RU work on the progesterone receptor. Which seems to be involved too. Ella is OTC in many countries and safe. Trying to find a link on the lowering serotonine part

Id say slow down a bit and try licorice root supplement. Will give you more energy and possibly better morning wood. Made me feel better mentally. Thats a good start to trying more serious stuff and you will survive until new year :)

raised 0,125mg every other day till 0,5 then slowing down to zero, weeks rest. 5ht1a antagonists have been discussed a long time on the PSSD forum, not with great results. I might consider something that lowers serotonine overall as augmentation however. cycling progesterone, ella, licorice root...

only on pssd forum. mental benefits, not much on libido. will be cycling instead of continiously raising dose. might try combinations if this doesnt help, still think it will be part of the solution.

if it didnt cause sides you mightve stopped too soon, it was a week?

im far from trigger happy on meds, so im open for any solution. but drugs i understand

@zadig777 Werent you on prep? Anything that gave me a window was in my second or 3rd week, so are you sure you gave it a chance?

Might as well use this thread @zadig777 @Helen Notice this was all purchased on internet, no prescription etc

Lets continue in pssd thread then :)

not really, assuming people tried good quality

i consider it a patch if it only works while on it, hence i like the idea of cycling things.