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Making this log for the purpose of detailing what I've tried and what effect it has had for anyone else's benefit. I'll keep this first post updated with what I've tried and what effect it has had. Took Accutane 20mg for 10 months when I was 19/20 (currently 23). Experienced sever sexual sides...

Ignore previous 2 posts of mine (that I just deleted). RU arrived. Thinking 3 days at 50mg and then waiting to see what happens. Possible follow up of 9 days at 50mg after that. Any thoughts and suggestions welcome :)

I'd say yes to 1, 2, 4 and 5 to varying extents. Magnitude is obviously greatly affected by whatever else is going on in life, but I feel those may be different from baseline. Strongest effects on 4 and 2. I've been eating really well, dairy and wheat free and intermittent fasting, so I have...

I think I am more anxious, possibly quite a bit but I feel it's hard to 100% attribute that because it could have so many possible causes. What about you?

What dose and duration did you use for your RU run? Ordered some from the place in Source Talk and gonna give it a go.

Strep throat infection was the trigger. Strep throat can cause rheumatic fever where antibodies produced against the bacteria can also attack the heart, joints and kidneys, so it is definitely capable of triggering sever reactions in the body.

Nah he never took Deca, but he noticed the symptoms were so similar that he guessed it must have something to do with progesterone.

I agree RU486 is worth a try. I would have tried it myself but it's so damn expensive and I don't know if it would get stuck in customs here.

No idea bro

I don't understand how the Zinc Finger works fully but it's a protein substructure that's in loads of transcription factors, so errors could mean over or under transcription. What I do know is that as soon as there's elevated progesterone (from elevated cortisol or whatever) sexual sides can...

That's awesome news man. You should definitely look to crowdfund some of it, even if people can only afford small donations. If he can show that hundreds of people have already donated their own money to support the research that'll really encourage the grant boards to cover the rest.

I know gbol is trying to cure MPB for good, but if he is unsuccessful or in the meantime you guys might want to check this out Those are the expensive ones but I've found heaps cheaper ones elsewhere

Bloods on TRT at 100mg/week DHEAS 3600 ug/L 1000 - 4000 OESTRADIOL (E2) * 200 pmol/L <150 PROGESTERONE * 3 nmol/L <3 Testosterone 26 nmol/L 10.0 - 33.0 SHBG 25 nmol/L 13 - 71 (older result) Electrolytes, Liver Function, Kidney Function and Cholesterol tests all normal LH and FSH are 0

The dose there is 600mg/day which is $250 a day at the places I'm finding it. Where are you getting it from?

In the study they injected the mifepristone directly into the CSF so I couldn't figure out an equivalent oral human dose. It does cross the BBB but brain levels are only 28% of serum levels. Study which says this says centrally mediated effects might only be applicable at high doses.

Hahaha definitely do not go back on and take it. Yeah in my opinion it would matter, because once you stop accutane the RA is removed. Whatever effects remain are not due to RA in your system. They are probably due to an adaption that happened in response to the chronic RA usage. Mifepristone...

On accutane or TRT?

Just read the study you're talking about. All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation. - PubMed - NCBI @Flynn you should give it a read if you haven't seen this yet. Retinoic acid increases CRH gene expression...

Which symptoms for you did Trestolone alleviate for you? Was it just the sexual symptoms or your energy and mood as well? I had never heard of it before. From what I'm reading it's an ultra strong androgen, moderate progestin and aromatises, so some oestrogen too, so pretty hard to pinpoint...

Maybe give it a bit longer man. The guy who got the bumpy road boner didn't say how long after stopping it took him to recover so it might need a bit longer.