5a-DHP

[Kjbigman]

What do you guys think of 5a-DHP, have you had success with it? It is a precursor to allopregnegnalone and is produced via progesterone with 5a-reductase. So supplementing it would bypass the need for 5-ar.

Not sure if this was posted elsewhere but I could not find anything on it.

 

[Walker]

There’s about a 20+ page thread on the compound over at Swole Source, if you haven’t checked that out yet.

 

[Kjbigman]

Update: I took 1mg of 5a-DHP in the midst of SEVERE brain fog. I would say that it is 50% alleviated. Also, I feel as if my eyesight is slightly sharper.

5a-DHP is a neurosteroid that binds to the progesterone receptor.

From Wikipedia:

5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor. [it enhances its activity].

It has also been found to act as a negative allosteric modulator of the GABAA-rho receptor. I am confused here, I don't know what the difference between these receptors really is.

I mentioned in an earlier post that alcohol has a similar effect on me in alleviating brain fog. Alcohol is also a positive allosteric modulator of GABA-A receptors in the brain.

From Haidut on Ray Peat forum:
5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions [can be neuroprotective in cases of degenerative diseases].

Also, lowers prolactin and is a pro-hormone for DHT. Can likely increase DHT in the brain, possibly CSF?

@Helen I know you have been talking about GABA for a long time so forgive me if this is repetitive. I just joined the forum.

 

[mbax44]

Sounds almost too good to be true lol. Also im sure someone here must have trialed it for awhile. Wondering if there’s any negative feedback or if intermittent use could get around that.

 

[Kjbigman]

Not only did the brain fog clear up but my pulse increased and I feel like I can breathe deeply. It's like while in brain fog I was drugged out, sedated, and couldn't even breathe properly.

Why would this be the case? If we assume there is a lack of allopregnegnelone in the brain we would expect there to be insufficient GABA-a, i.e. an excitable state, correct? Yet here, I am taking GABA-agonizing substances and it is actually producing the exact opposite effect.

 

[Helen]

@Kjbigman Of course 5a-DHP helps. 5AR is closed , since you are taking finasteride. And taking 5a-DHP bypasses it. tons of people cycled it on Ray Peat forum . Don't forget we came here from Ray Peat forum mostly, so most people took 5a-DHP.

Also don't confuse being on fin and being off fin.

I think it is an excellent idea to take fin with 5a-DHP, if you have to take fin. It might even help you come off from fin without gaba problem.


Bud for you it can't increase DHT in the brain, since you are taking fin. But taking 5a-DHP with fin is an excellent idea. May be gaba won't be as effected by fin. and when you come off, you will have one less problem.

 

[TubZy]

@Kjbigman can you please get the tests we asked? It would be a huge help to see what fin is really doing while someone has been on the drug as long as you have. Maybe even a hair test too @Helen

 

[Helen]

@Kjbigman can you please get the tests we asked? It would be a huge help to see what fin is really doing while someone has been on the drug as long as you have. Maybe even a hair test too @Helen

dude, he is fucking everything up already. he is bypassing 5AR now, with 5a-DHP. tests will be all fucked.

@Boris, but it could be an excellent idea to add 5a-DHP to people who take fin. It might screw up the brain much less after you come off.

 

[Trump_1776]

dude, he is fucking everything up already. he is bypassing 5AR now, with 5a-DHP. tests will be all fucked.

@Boris, but it could be an excellent idea to add 5a-DHP to people who take fin. It might screw up the brain much less after you come off.

@Kjbigman can you please get the tests we asked? It would be a huge help to see what fin is really doing while someone has been on the drug as long as you have. Maybe even a hair test too @Helen

Didn't you trial 5a dhp back in the day?

 

[Helen]

@Boris the only thing is , that people got screwed up on RU4588 or whatever that thing is. and that thinkg does not block 5AR.

that thing just blocks AR receptor and people came off, and got fucked similar to Finasteride.

 

[TubZy]

Didn't you trial 5a dhp back in the day?

Yeah first few doses initially I felt great on it mentally. It didn't do too much sexually, but mentally I felt great, killed stress/anxiety/had energy etc. but it eventually wore off after continued use and never responded to it again at all even after taking long breaks. So I stopped pursuing it especially once figuring out its basically a progestin

 

[TubZy]

@Boris the only thing is , that people got screwed up on RU4588 or whatever that thing is. and that thinkg does not block 5AR.

that thing just blocks AR receptor and people came off, and got fucked similar to Finasteride.

even if he ceased 5ahp and the other supplements and continued to take fin, wouldn't his hormones level back out to at least gauge a somewhat accurate blood test of what it looks like on fin? I mean he has been on it for 8 months. I can't imagine 5a-dhp messing it with it that bad, its half life is pretty short

 

[Helen]

even if he ceased 5ahp and the other supplements and continued to take fin, wouldn't his hormones level back out to at least gauge a somewhat accurate blood test of what it looks like on fin? I mean he has been on it for 8 months. I can't imagine 5a-dhp messing it with it that bad, its half life is pretty short

If he stops 5a dhp, and gets tested yes. I mean the guy is on finasteride for along time, he could have helped us, but if he starts taking 5a-dhp ( which is a a good idea)

his gaba will change and his whole body chemistry will change. Since gaba is involved in cortisol release, in calcium metabolism. etc

 

[bruschi11]

This is actually only thing that stopped my chronic non stop panic attacks other than antidepressants, anti-anxieties within a week or two of getting pfs.

Completely lost reactivity to it within a week. After I spent 500 dollars on as much I could possibly buy.