Accutane Specifically thread- Accutane protocol? Any help appreciated 19 years old

[PAS]

Also, can you guys discuss and instruct what willylong took in what dosages when he felt temporarily normal. Its been 2.5 years and I dont know if its possible to be pre isotret anymore. I just want to find out if the damage is permanent. @gbolduev @Willylong98 and others who have any idea bros can you suggest chemicals and their dosages for this temporary fix.

 

[IHateFin]

Also, can you guys discuss and instruct what willylong took in what dosages when he felt temporarily normal. Its been 2.5 years and I dont know if its possible to be pre isotret anymore. I just want to find out if the damage is permanent. @gbolduev @Willylong98 and others who have any idea bros can you suggest chemicals and their dosages for this temporary fix.

the damage is never permanent. its just a matter of trying to understand what happened and taking the right steps to reverse it. unfortunately these ailments are infinity complex and seem "permanent"

 

[Flynn]

Also, can you guys discuss and instruct what willylong took in what dosages when he felt temporarily normal. Its been 2.5 years and I dont know if its possible to be pre isotret anymore. I just want to find out if the damage is permanent. @gbolduev @Willylong98 and others who have any idea bros can you suggest chemicals and their dosages for this temporary fix.

Have you ever experimented with dopamine agonists or drugs that affect the dopamine system? If so, can you recall trying them before and after accutane? I'm interested in this and looking into the dopamine side of things related to accutane as I am convinced part of our problem may lie with dopamine issues (either excessive upregulation of receptors/downregulation or dysfunction of the pathway).

 

[PAS]

Have you ever experimented with dopamine agonists or drugs that affect the dopamine system? If so, can you recall trying them before and after accutane? I'm interested in this and looking into the dopamine side of things related to accutane as I am convinced part of our problem may lie with dopamine issues (either excessive upregulation of receptors/downregulation or dysfunction of the pathway).

No bro, I haven't dabbled in chemicals. The only thing that PROBABLY helped is exercise. My dysfunction just lessened a bit, but no improvements in libido or anhedonia. One more thing that makes me think its not just dopamine etc is that I used to have the fastest growing beard I have ever seen in any man. I used to look in a month what other people looked like in an year. Since isotret, I haven't been able to grow a beard past a certain point only. Makes me think that DHT is fumbled. Of course it's never a single thing, as @IHateFin said and you already know, its infinitely complex.

 

[Flynn]

No bro, I haven't dabbled in chemicals. The only thing that PROBABLY helped is exercise. My dysfunction just lessened a bit, but no improvements in libido or anhedonia. One more thing that makes me think its not just dopamine etc is that I used to have the fastest growing beard I have ever seen in any man. I used to look in a month what other people looked like in an year. Since isotret, I haven't been able to grow a beard past a certain point only. Makes me think that DHT is fumbled. Of course it's never a single thing, as @IHateFin said and you already know, its infinitely complex.

Yeah its an interesting observation. I'm doing some research into the dopamine stuff. I honestly hope you're right about it simply being hormones, that would make life a whole lot simpler. The only comment I would make about judging things by beard hair alone, is that accutane is known to affect hair growth on the hair, cause shedding, dry, brittle hair etc. so its possible it has also affected facial hair. Just a possibility.

 

[IHateFin]

Yeah its an interesting observation. I'm doing some research into the dopamine stuff. I honestly hope you're right about it simply being hormones, that would make life a whole lot simpler. The only comment I would make about judging things by beard hair alone, is that accutane is known to affect hair growth on the hair, cause shedding, dry, brittle hair etc. so its possible it has also affected facial hair. Just a possibility.

im sure dopamine was affected, but its definitely not the root cause. i haven't done any research on accutane specifically nor PSSD just PFS since that what i have, but they all seem to have affected DHT, progesterone, prolactin and cortisol the most. dopamine will be indirectly affected if any of these are out of wack since DHT and its metabolites are strongly connected to GABA receptors and the modulation of GABA and dopamine are linked in fact activation of GABA receptors can make dopamine more sensative. its probably some kind of balancing mechanism since one is a CNS depressant and one is a stimulant.

DHT can contribute to acne since it increases oils, sebum under the skin so i wouldnt be surprised if i found out on of the ways accutain works is to directly inhibit dht. Finasteride has been known to clear up skin of the user too.

have you read the thread here about how finasteride can actually cure post accutain? it was pretty mind blowing. they definitly must work differently in the body, yet can cause identicle side effects.

 

[PAS]

Its not limited to facial hair, I don't have as much natural muscle mass as I would have otherwise. DHT is definitely affected by isotretinoin.
Thats how 5ar work right? Fin blocks dht in the head, how it supposedly targets only the head is a mystery to me, but this is what wrong with us. It targeted global dht production for you guys.

 

[IHateFin]

Its not limited to facial hair, I don't have as much natural muscle mass as I would have otherwise. DHT is definitely affected by isotretinoin.
Thats how 5ar work right? Fin blocks dht in the head, how it supposedly targets only the head is a mystery to me, but this is what wrong with us. It targeted global dht production for you guys.

It doesn't target 5 alpha reductase in just the head that's why we all get fucked from it haha
5AR is all over skin, prostate, brain, CNS you name it, penis all over the place in 3 ISO forms and both drugs destroy primarily 5 alpha reductase type 2 and 1, but I'm sure type 3 is affected too

 

[Flynn]

im sure dopamine was affected, but its definitely not the root cause. i haven't done any research on accutane specifically nor PSSD just PFS since that what i have, but they all seem to have affected DHT, progesterone, prolactin and cortisol the most. dopamine will be indirectly affected if any of these are out of wack since DHT and its metabolites are strongly connected to GABA receptors and the modulation of GABA and dopamine are linked in fact activation of GABA receptors can make dopamine more sensative. its probably some kind of balancing mechanism since one is a CNS depressant and one is a stimulant.

DHT can contribute to acne since it increases oils, sebum under the skin so i wouldnt be surprised if i found out on of the ways accutain works is to directly inhibit dht. Finasteride has been known to clear up skin of the user too.

have you read the thread here about how finasteride can actually cure post accutain? it was pretty mind blowing. they definitly must work differently in the body, yet can cause identicle side effects.

Yeah I honestly hope you're right dude. I will look into GABA being able to sensitise dopamine, that would make things interesting. So the idea is that a lack of GABA activation due to deficiencies of DHT related hormones could result in dopamine insensitivity?

I am going to post some stuff soon, but there is a relationship between retinoic acids and dopamine receptor expression. Essentially, increasing reintoic acids (accutane) can increase dopamine receptor expression, this may persist, which could lead to an excess of dopamine receptors, and possibly a dysfunction in receptor/dopamine binding. This could result in a desensitised dopamine response. If this is the case, I fear its a much bigger problem, which could be very tough to treat though not impossible

 

[Flynn]

Its not limited to facial hair, I don't have as much natural muscle mass as I would have otherwise. DHT is definitely affected by isotretinoin.
Thats how 5ar work right? Fin blocks dht in the head, how it supposedly targets only the head is a mystery to me, but this is what wrong with us. It targeted global dht production for you guys.

how do you know you have less muscle mass than otherwise? I have most of the PAS symptoms such as sexual sides etc. I took when I was 14 so I don't know if I would have had more muscle mass now. But my muscle mass seems to be normal, I am actually stronger than most. So I don't feel accutane affected me in this way.

 

[PAS]

I ll go on a 3 day water fast starting now. I have never fasted before,are 3 days enough, assuming I am even able to get through it ( or will 3 days be too much, what length do you guys suggest?
)

 

[PAS]

how do you know you have less muscle mass than otherwise? I have most of the PAS symptoms such as sexual sides etc. I took when I was 14 so I don't know if I would have had more muscle mass now. But my muscle mass seems to be normal, I am actually stronger than most. So I don't feel accutane affected me in this way.

I took isotret for the 2nd time when I was 20 ( the first time when i was 15 PAS didnt occur), so I knew how I was normally built. After isotret I grew fatter and muscle mass decreased, although only a little, maybe because I didn't have very much then. Coincidentally I am also stronger than most, its been that way since childhood.

I am still waiting on some advice for the temporary fix if someone is able to help.
One thing I also noticed while reading this forum is that PAS members seem to be hit with non sexual anhedonia too. I personally have complete anhedonia, cant feel good or excited for/from anything, even music. What are PFS guys thoughts. This might be something to look into concerning differences bw PAS and PFS

 

[PAS]

It doesn't target 5 alpha reductase in just the head that's why we all get fucked from it haha
5AR is all over skin, prostate, brain, CNS you name it, penis all over the place in 3 ISO forms and both drugs destroy primarily 5 alpha reductase type 2 and 1, but I'm sure type 3 is affected too

Exactly, this is why I wrote 'supposedly' lol, it was low key sarcasm at the manufacturers, didn't come out the right way in writing sorry.

 

[barbaar]

I took isotret for the 2nd time when I was 20 ( the first time when i was 15 PAS didnt occur), so I knew how I was normally built. After isotret I grew fatter and muscle mass decreased, although only a little, maybe because I didn't have very much then. Coincidentally I am also stronger than most, its been that way since childhood.

I am still waiting on some advice for the temporary fix if someone is able to help.
One thing I also noticed while reading this forum is that PAS members seem to be hit with non sexual anhedonia too. I personally have complete anhedonia, cant feel good or excited for/from anything, even music. What are PFS guys thoughts. This might be something to look into concerning differences bw PAS and PFS

Anhedonia is definitely also a part of PSSD. Not sure about PFS.

 

[IHateFin]

Exactly, this is why I wrote 'supposedly' lol, it was low key sarcasm at the manufacturers, didn't come out the right way in writing sorry.

lol my bad. I also sometimes don't read as thoroughly as I should

 

[IHateFin]

Yeah I honestly hope you're right dude. I will look into GABA being able to sensitise dopamine, that would make things interesting. So the idea is that a lack of GABA activation due to deficiencies of DHT related hormones could result in dopamine insensitivity?

I am going to post some stuff soon, but there is a relationship between retinoic acids and dopamine receptor expression. Essentially, increasing reintoic acids (accutane) can increase dopamine receptor expression, this may persist, which could lead to an excess of dopamine receptors, and possibly a dysfunction in receptor/dopamine binding. This could result in a desensitised dopamine response. If this is the case, I fear its a much bigger problem, which could be very tough to treat though not impossible

That's what I'm thinking.
I know for a fact finasteride causes changes in GABA and GABA expression because of it decreasing dht and thus gabageneric metabolites of dht such as androsterone being the biggest one. This could be why some experince persistent insomnia from finasteride.
If you're looking to tackle this the GABA route then Randro would be worth trying as that's androsterone in a pill. Androsterone is also 5 alpha reduced.
Also inositol has been shown to significantly increase D2 receptors and serotonin receptors.

 

[IHateFin]

Anhedonia is definitely also a part of PSSD. Not sure about PFS.

Can confirm it's part of PFS. Twas hard to truely enjoy anything with PFS honestly

 

[MNK99]

Yeah pretty sure it's there in both too. I love hip hop and Trance... couldn't listen to any of the former after PSSD for months. Now with PFS -- barely can listen to music at all. Trying tho!! Let alone movies and books... I sometimes read 2-3 books a day (usually when cramming, or late!) I have authors I've been dying to read and nothing really to do so I should... but it's hard. Dostoyevsky and Kafka. I'm not sure I'd enjoy them right now... I wanted to read them when certain challenges were completed. I successfully completed said challenges but now I'm facing new ones... Soon enough I'll read them.

 

[Willylong98]

Does anyone know if I should he supplementing with electrolytes because I have adrenal insufficiency and can literally feel how low I am in them I’m always shaky and weak and tired with headaches every morning all day

 

[Willylong98]

@gbolduev any insight would help thanks