Agmatine, Allopreg and GABA

[RebelWithACause]

What about low-dose fluoxetine (prozac) to increase allo? .5 - 1mg has been shown to increase allo without the ssri properties of typically prescribed doses.

I got a script just for shits awhile back to experiment with low doses, but never ended up going for it.

Ari from JRE went on SSRI's after crashing from finasteride and then stopped the drugs and I think the guy is recovered. Could be that he used Prozac. I also remember a post on PH of a guy using Prozac and recovering. I don't remember if he stayed on the drug.

 

[MNK99]

Definitely studies and or personal reports mentioning something about increasing allopreg with 5mg or 2.5mg prozac. I can't recall where but I've seen them. Solvepfs, xptriado, but also actual studies iirc.

 

[TubZy]

yeah it also seems to highly protective in maintaining protective anti oxidant systems especially in the brain (SODs, glut etc.)

Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice - ScienceDirect
Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages
https://www.degruyter.com/downloadpdf/j/afmnai.2016.33.issue-1/afmnai-2016-0002/afmnai-2016-0002.pdf
Agmatine Improves Renal Function in Gentamicin-Induced Nephrotoxicity in Rats | Dalia H El-Kashef | Request PDF
The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis. - PubMed - NCBI
https://www.degruyter.com/downloadpdf/j/afmnai.2014.31.issue-4/afmnai-2014-0029/afmnai-2014-0029.pdf
Neuroprotective Role of Agmatine in Neurological Diseases


Bratislav found that agmatine could exert its anti-oxidative effect by protecting antioxidant defense system and restoring the antioxidant capacity in liver tissue [114]. Besides, several studies had demonstrated the anti-oxidative effect of agmatine in the setting of neurological diseases. Gawali and his colleagues reported that agmatine could ameliorate depressive-like behavior by reducing the oxidative/nitrosative stress evoked by LPS in hippocampus and prefrontal cortex [115], and this effect may be achieved via preventing lipid peroxidation and regulating the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) [116]. In addition, agmatine has also been proved to exert anti-oxidative stress in stroke and TBI by reducing the generation of reactive oxygen species (ROS) and free radicals [11].