If you give RU a try, could you do a log please. It will very informative to get logs of PAS people who try RU
Any PAS (post accutane) sufferers with sexual side effects tried RU486 or ELLA?
- Thread starter Flynn
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If you give RU a try, could you do a log please. It will very informative to get logs of PAS people who try RU
cnb30
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I’m heasitant to be the 1st one to try it (as I am a male).
Ok, many males on this forum have tried it. RU is not the kind of drug that will leave you with any long term side effects. I intend to take it soon. So I will let you know how it goes for me first, then you can decide.
@Flynn and others, how did you decide to take RU and / or ella. What blood levels did you see to determine that RU will work for you? I see people taking progesterone, RU, ella , Randro ? How to decide which one to take and which one to not.
I am asking in the sense of what to take when progesterone is low for example, and what not to take? Or are we determining based on cortisol or serotonin levels. There is a lot of information on this thread, but it is all spread out in different threads and posted at different times which may result in it being outdated. Can somebody assist me in this or if someone already has informative links saved can provide them.
I am trying to do a 101 of sorts with information on the mechanisms of fin, iso and mechanisms of the treatments. But there are so many different things which these chemicals have altered. Many discussions focus on receptors of hormones like progesterone, testosterone. Many focus on dopamine, serotonin and cortisol levels. They are obviously related but we don't know how. And also the studies which shed light on these topics are themselves in the prototypical state, so it is difficult to determine the veracity of these pieces of info also.
Again, if someone can provide any primer or similar links and / or tell which information about these diseases is definitely true, many including me be very thankful to you.
I am asking in the sense of what to take when progesterone is low for example, and what not to take? Or are we determining based on cortisol or serotonin levels. There is a lot of information on this thread, but it is all spread out in different threads and posted at different times which may result in it being outdated. Can somebody assist me in this or if someone already has informative links saved can provide them.
I am trying to do a 101 of sorts with information on the mechanisms of fin, iso and mechanisms of the treatments. But there are so many different things which these chemicals have altered. Many discussions focus on receptors of hormones like progesterone, testosterone. Many focus on dopamine, serotonin and cortisol levels. They are obviously related but we don't know how. And also the studies which shed light on these topics are themselves in the prototypical state, so it is difficult to determine the veracity of these pieces of info also.
Again, if someone can provide any primer or similar links and / or tell which information about these diseases is definitely true, many including me be very thankful to you.
Right now, nobody really knows whats going on. The symptoms of PFS and PAS etc. are similar but there is no reason to assume they are caused the by the same problem. I am currently doing some research to try to provide a hypothesis or possible theory. As you say, its very difficult as most research has been undertaken in other organisms such as rats or mice or doesn't exist. Generally, there isn't a whole lot of research into accutane.
There is reason to believe accutane affects both progesterone and cortisol, these changes likely manifest as changes in hormone levels or changes in receptors. We don't know,but I would guess receptors. Clearly these changes have occurred in the brain which makes sense given the density of retinoid receptors in the brain.
RU has an effect on both prog receptors and cortisol receptors. This is reason enough to try it. If when you take RU-486 you feel an improvement in sexual symptoms either during treatment or after treatment, it would give us a strong indication of how accutane has altered our brains to produce these persistent effects. Of course, if RU-486 does nothing, it indicates the problem may lie somewhere else. As such as we must then look elsewhere. Either way there is something to be learnt, and the more people with PAS who try this, the better, as we need as much data as possible. As I said, there is little reason to believe, taking one RU pill split between 3-4 days would have any lasting negative effect on your health (a pill is 200mg, studies have found use dosages as high as 600mg in one administration). So in my view its just the price thats the real issue of trying RU.
The truth is, accutane clearly has many effects on the body as lots of drugs do. The issues here is, its easy to find studies showing that accutane has X effect on your body. It's easy to get very worried and panicked. The truth is, I would guess the majority of these effects are reversed after several months of stopping treatment, and are completely irrelevant to the cause of many PAS symptoms. Thus lots of people online are trying to supplement or reverse perceived damage accutane could have caused, which likely has already healed or been restored.
A big positive factor to look at here is the fact that accutane is/has been prescribed to millions of people. The majority of people don't get these PAS symptoms (or at least we don't think they do), thus it makes the possibility that accutane has caused brain damage or destroyed neural circuitry in the brain less likely (though not impossible). If we are lucky, this simply relates to a change in receptor expression/activity in the brain, which given the correct stimulus could be reversed.
Right now R-andro doesn't seem like it would do much as people who have experimented with high levels of steroids have seen little if any positive results. Ella is a weaker form of RU and doesn't effect cortisol. RU has an effect on both cortisol and prog, and it has been shown to have significant effects in some people with PFS. Given this, I think RU makes the most sense to try.
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Yes I actually doubt RU will help directly in relation to hormones, I think this will help in regards to changing receptor activity/expression. I could be wrong, but there is far too much evidence now to not give this a try.
It's crazy that pretty much nobody with PAS has tried this yet, despite the effects it has on prog and cortisol receptors/activity and the likely effects of accutane on prog and cortisol.
cnb30
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I’m sorry but at the moment I can in no way shape or form afford that.
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Then maybe try Ella, it is a lot cheaper or go on a fast - that is free. There are many other things you can do, look at the links in my sig
@Flynn @Willylong98 how much Ru are you taking and how did you arrive at that conclusion
I've ordered one 200mg pill to see if the website is trustworthy. I will split the pill up and weigh it into 50mg doses. I will take 50mg for 4 days and see how I feel afterwards. This is based on the logs of PFS people who have tried RU. Depending how this cycle goes, I will consider doing a higher/lower dose for a longer time period next time.
Hard to say which side effects are due to accutane or a result of other side effects. Only side effect I really care about right now, is sexual sides. I will be monitoring these when taking RU. Do you have sexual sides? Also have you ever had your progesterone tested?
tanedout
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Have you got high cortisol? If you do it (RU486) could potentially be prescribed if what you have looks like cushings disease