Dark0047 post_id=3123 time=1509462672 user_id=124 said:
aztec, I have tested my blood hormones quite a lot.My progesterone is so high. It should be <26 but it is 1.6. How can progesterone cause genital anesthesia or sexual dysfunction. I couldn't find any evidence suggest that. I also tried herbs. They helped me with libido but not with numbness. As I said before I don't have much problem with libido or erection only numbness. So you thing Ella can help me in this situation?
I saw you saying that you tested neurotransmitters and all that stuff, but you need to understand one thing, our condition happens at SNC level, so whats shown in the blood has limited meaning.
From the book Neurosteroids and the Nervous System by Steven R. King
Steroids can be analgesic at the level of the brain. I.c.v. allopregnanolone, 3aHP, and, to a lesser extent, progesterone increase thermal pain thresholds in male mice via a GABA A receptor-dependent mechanism.
Intrahippocampal finasteride reduces allopregnanolone and tends to enhance analgesia.
A separate study fi nds that micromolar intrathecal allopregnanolone and its 5b isomer decrease sensitivity to mechanical pressure
Just a few examples, theres a whole chapter with examples of neurosteroids causing some kind of analgesia(pressure, heat...), mainly Allo which is synthesized from Progesterone. While studying these effects, altered levels of the neurosteroids couldnt be found in SERUM only in spinal cord and brain. Melcangi found the same thing with PFS sufferers, normal serum but altered values in CSF.
What Im trying to say is that maybe progesterone isnt the culprit for the symptoms, just the cause of all the mess who led to all this kind of crap that we are stuck. And serum levels may not reflect whats happening on SNC level.
Regarding your question, I will let [mention]barbaar[/mention] answer =)