Aztec PFS/Ella Log *Recovery*

[barbaar]

aztec, I have tested my blood hormones quite a lot.My progesterone is so high. It should be <26 but it is 1.6. How can progesterone cause genital anesthesia or sexual dysfunction. I couldn't find any evidence suggest that. I also tried herbs. They helped me with libido but not with numbness. As I said before I don't have much problem with libido or erection only numbness. So you thing Ella can help me in this situation?

I saw you saying that you tested neurotransmitters and all that stuff, but you need to understand one thing, our condition happens at SNC level, so whats shown in the blood has limited meaning.

From the book Neurosteroids and the Nervous System by Steven R. King

Steroids can be analgesic at the level of the brain. I.c.v. allopregnanolone, 3aHP, and, to a lesser extent, progesterone increase thermal pain thresholds in male mice via a GABA A receptor-dependent mechanism.

Intrahippocampal finasteride reduces allopregnanolone and tends to enhance analgesia.

A separate study fi nds that micromolar intrathecal allopregnanolone and its 5b isomer decrease sensitivity to mechanical pressure

Just a few examples, theres a whole chapter with examples of neurosteroids causing some kind of analgesia(pressure, heat...), mainly Allo which is synthesized from Progesterone. While studying these effects, altered levels of the neurosteroids couldnt be found in SERUM only in spinal cord and brain. Melcangi found the same thing with PFS sufferers, normal serum but altered values in CSF.

What Im trying to say is that maybe progesterone isnt the culprit for the symptoms, just the cause of all the mess who led to all this kind of crap that we are stuck. And serum levels may not reflect whats happening on SNC level.

Regarding your question, I will let @barbaar answer =)

@shadow Damn good find! That might very well be the mechanism causing the numbness.

mood disorders and sexual dysfunction are frequently-seen side effects of 5α-reductase inhibitors such as finasteride, and are thought to be caused, in part, by interfering with the normal production of allopregnanolone.

Well then.

@Dark0047 I found ella definitely helped increase my sensitivity. It's too early to tell for me if the benefits stuck, but I'd say it's certainly worth a shot.

 

[Dark0047]

Shadow, sorry dude. I am a bit confused. What you said was a bit complicated for me to grasp. You mean that Ella could help or not?

 

[Shadow]

Shadow, sorry dude. I am a bit confused. What you said was a bit complicated for me to grasp. You mean that Ella could help or not?

It helped some people, read what barbaar said after my previous post. Soon I will be trying Ella too, as you, my sensitivity is very bad, and not only on genitals, but the whole skin.

I think that Ella worth a shot!

 

[Dark0047]

Shadow, sorry dude. I am a bit confused. What you said was a bit complicated for me to grasp. You mean that Ella could help or not?

It helped some people, read what barbaar said after my previous post. Soon I will be trying Ella too, as you, my sensitivity is very bad, and not only on genitals, but the whole skin.

I think that Ella worth a shot!

What drug did you take that caused your numbness?

 

[Shadow]

Shadow, sorry dude. I am a bit confused. What you said was a bit complicated for me to grasp. You mean that Ella could help or not?

It helped some people, read what barbaar said after my previous post. Soon I will be trying Ella too, as you, my sensitivity is very bad, and not only on genitals, but the whole skin.

I think that Ella worth a shot!

What drug did you take that caused your numbness?

LexaPro(Escitalopram)

 

[aztec]

[mention]Dark0047[/mention] sounds you like you have an answer now. The guys offered some good insight. Test Ella out and see how you react. It could be helpful! Keep us posted.

 

[BeLikeWater]

aztec, I have tested my blood hormones quite a lot.My progesterone is so high. It should be <26 but it is 1.6. How can progesterone cause genital anesthesia or sexual dysfunction. I couldn't find any evidence suggest that. I also tried herbs. They helped me with libido but not with numbness. As I said before I don't have much problem with libido or erection only numbness. So you thing Ella can help me in this situation?

I saw you saying that you tested neurotransmitters and all that stuff, but you need to understand one thing, our condition happens at SNC level, so whats shown in the blood has limited meaning.

From the book Neurosteroids and the Nervous System by Steven R. King

Steroids can be analgesic at the level of the brain. I.c.v. allopregnanolone, 3aHP, and, to a lesser extent, progesterone increase thermal pain thresholds in male mice via a GABA A receptor-dependent mechanism.

Intrahippocampal finasteride reduces allopregnanolone and tends to enhance analgesia.

A separate study fi nds that micromolar intrathecal allopregnanolone and its 5b isomer decrease sensitivity to mechanical pressure

Just a few examples, theres a whole chapter with examples of neurosteroids causing some kind of analgesia(pressure, heat...), mainly Allo which is synthesized from Progesterone. While studying these effects, altered levels of the neurosteroids couldnt be found in SERUM only in spinal cord and brain. Melcangi found the same thing with PFS sufferers, normal serum but altered values in CSF.

What Im trying to say is that maybe progesterone isnt the culprit for the symptoms, just the cause of all the mess who led to all this kind of crap that we are stuck. And serum levels may not reflect whats happening on SNC level.

Regarding your question, I will let @barbaar answer =)

Serum Levels not reflect what is happening in SCN level.

Just to comment during a 4 days water fast my pennis sensitive came back to normal for a day was very special situation.

 

[aztec]

Quick 2 week update: I went on a blind date with a girl last night and she was cute. We talked and laughed a lot which felt great. There was chemistry so lots of hugging and caressing took place shortly after. My libido was definitely present and I had a big strong boner that she enjoyed feeling while we hugged haha! Something magical happens in our bodies when attraction and physical contact are both present. I strongly suggest going out guys because it adds to healing the entire body.

I did not expect myself to feel so aroused on this date. I couldn’t stop thinking about her and the idea of making sweet love soon. I almost shot a round off in my pants Natural lubrication was awesome and I was happy because 3 months ago my dick felt dry and precum was absent. I am feeling lubrication present now like the pre-fin days. My balls are feeling blue because they wanted action but I had to give them a pep talk and remind them of being patient.

 

[Shadow]

Awesome news aztec!!

 

[ruprmurdoch]

Aztec could you explain me, does Ella work in the same way as RU?

 

[aztec]

[mention]Shadow[/mention] thanks buddy!

[mention]ruprmurdoch[/mention] Ella and ru 486 have similar mechanisms but there is a difference. Ella can agonize and atagonize progesterone receptors. Ru 486 antagonizes progesterone receptors.

 

[5 alpha]

@Shadow thanks buddy!

@ruprmurdoch Ella and ru 486 have similar mechanisms but there is a difference. Ella can agonize and atagonize progesterone receptors. Ru 486 antagonizes progesterone receptors.

is it the other way around?

ru 486 can actually agonize and antagonize the receptors right?

i thought that it was Ella that was different in that regard.

 

[aztec]

[quote="5 alpha" post_id=3488 time=1509835852 user_id=57]

@Shadow thanks buddy!

@ruprmurdoch Ella and ru 486 have similar mechanisms but there is a difference. Ella can agonize and atagonize progesterone receptors. Ru 486 antagonizes progesterone receptors.

is it the other way around?

ru 486 can actually agonize and antagonize the receptors right?

i thought that it was Ella that was different in that regard.
[/quote]
No, it is the way I mentioned it. Ella is selective progesterone receptor modulator which means it has aganostic and atagonistic properties on the receptor level. Read page 5: https://www.accessdata.fda.gov/drugsatf ... 000lbl.pdf

 

[Helen]

ella and ru both do the same stuff on progesterone receptors. RU strongly blocks cortisol receptors though, that is the difference.

 

[IHateFin]

Quick 2 week update: I went on a blind date with a girl last night and she was cute. We talked and laughed a lot which felt great. There was chemistry so lots of hugging and caressing took place shortly after. My libido was definitely present and I had a big strong boner that she enjoyed feeling while we hugged haha! Something magical happens in our bodies when attraction and physical contact are both present. I strongly suggest going out guys because it adds to healing the entire body.

I did not expect myself to feel so aroused on this date. I couldn’t stop thinking about her and the idea of making sweet love soon. I almost shot a round off in my pants Natural lubrication was awesome and I was happy because 3 months ago my dick felt dry and precum was absent. I am feeling lubrication present now like the pre-fin days. My balls are feeling blue because they wanted action but I had to give them a pep talk and remind them of being patient.

hahaha nice! dude your story telling abilities are next level! :lol:
good signs, man!

i know you got your new herb stack! what are your plans for future ella experimentation?

 

[IHateFin]

from my understanding is that, yes, Ella is SPRM and will agonize or antagonize receptors right out of the gate while RU will only antagonize receptors completley in the presence of biological progesterone. once prog falls only then will it agonize the prog receptors.

ru affinity for prog receptors is 5 times that of progesterone, 18 times that of cortisol and 4 times WEAKER than testosterone for the androgen receptors.

ella im not as well versed with lol

 

[aztec]

[mention]IHateFin[/mention] haha thanks my dude! Your sense of humor is contagious. Yes, I am excited about throwing in the 6 herb rotarion cycle beginning tomorrow. In terms of Ella, I might do a 3 day cycle or might even try a 3 day ru 486 cycle if needed once I finish the herbs. Overall, I am doing pretty good. I’m looking forward to hearing about all your new gains soon brother! Just in time for Thanksgiving...bam!

 

[ruprmurdoch]

Thanks guys, wonder why docs dont have this type of conversation. One more time THANK YOU gbold for ALL you done. Aztec it's great that you making huge progress.

 

[Shadow]

@M[mention]MNK99[/mention] what kinf of non sexual symptoms you had?

Im being suffering some severe ones from escitalopram discontinuation

 

[MNK99]

[mention]Shadow[/mention]
TBH, I was a kid back then, at 20-21ish. I have holes in my memory, I literally nearly lost everything.
I was always highly intelligent, if somewhat eccentric, but my mix of brain chemistry with those god awful drugs made my life super crazy for 6-9 months. AND HARD for the next several years. Especially when I didn't understand why.

Severe mania, bad people around me - inabilty to see it.
Worsened cognition. Screwed me up in school. Misplaced trust. 30lb weight gain (after losing 70lb).
Having ADHD (for sure) and other possible mood issues --- being on effexor and most psych drugs is a big mistake. My doctor was mistaken in diagnosis. She seemed sweet but caused me catastrophic events. It was a bad few years that followed. It ruined my academic career, and name in my community somewhat. I conquered all that, but it was hard to envision a brighter future at the time.


-Re: Antidepressants for me were total poison and like a lobotomy. Effexor, Zoloft, Prozac, Seroquel, Ativan --- were all recovered by. Damage to life maybe 3-4 years, physically visible? 1.5-2 years, sexual accuity? 2 years. I was hurt badly though, some of those above were 6 weeks, 2 days, 1 day use. Supposedly I have ADHD + Bipolar II --- so an antidepressant without a mood stabilizer is basically jumping off a cliff. I didn't know, nor did the "genius" doctors. I did know tho as i became healthy to meditate, run and eat right. And I got better as much as I could. I had stuff I had to treat tho. If sex dysfunction is the only issue, count yourself lucky. I disappeared from existence overnight and changed countries, I lost 40k? Plus 2 years tuition, and 2 years school progress, more. Wandered around, lost when I moved twice in 3 mo (different countries), and prayed an MRI would show what had happened.
I'm over all that. Was, til recent injury.