Bulletproof Gut Protocol - Questions, Comments, Experiences

[Helen]

@joekool Also wanted to clarify things for you a little bit more.

Glycine by putting chloride into the cell, inhibits NADPH oxidase. that is how it rases NADPH.

B1 also raises NADPH, by increasing transkelotase, and recycling OF SUGAR in pentose pathway.

NADPH is made from SUGAR. and without sugar , glycine cant not increase NADPH, since there will be nothing to inhibit, there will be no NADPH. and thus no NADPH oxidase

 

[Helen]

@joekool and now we get to the most important thing. increasing NADPH. with b1 , b5, NAD , increases estrogen.

since estrogen regulates directly NADPH production.

Aromatase is the enzyme with the highest need for NADPH. It uses the whole 3 NADPH molecules, to convert testosterone to estradiol.

this is why when I gave B1 to people in high or normal dosages and then tested them their estrogen was double. Aromatase - Wikipedia


So low sugar diet basically anti estrogen diet mostly since estrogen needs so many NADPH. and anti DHT. You cant not make NADPH without sugar, NADPH is SUGAR. you need to get it. so if you go low carbs, you go LOW NADPH, and you lower 5AR. and you also lower aromatase

 

[Helen]

@joekool Now lets look at Jack17's case.

the guy has high DHT, high test, typical slow oxidizer.

He takes dutasteride. and feels totally recovered. totally free of all symptoms.

His 5AR goes down on Dutasteride. He feels recovered while inihbiting 5AR. while on it.


question is This. Do fin and dutasteride, just kills 5AR by some mechanism, or they kill NADPH.

So lets just consider 2 variants.


1) if they kill 5AR by some mechanism, then testosterone goes up, and estrogen goes up, and allopregnenolone goes down, and 3 adiol goes down since these are dependant of 5 ar. , the last 2 switch off gaba.

So in this case we can imagine that gaba receptor will get overexpressed.

and then when you come off the drug you start hitting this high gaba. which increases prolactin, suppresses dopamine and acetycholine release, and prolactin tells the body to retain calcium.

Since calcium is being retained, body has to switch off estrogen, since estrogen also lowers dopamine and converts it to noradrenaline and increases prolactin. And also retains calcium.

but if GABA is already doing this. then estrogen gets closed. and you get unavailable copper.and no estrogen action .


2) second variant, is if Dutasteride, and Finasteride kills NADPH production.

then this will effect aromatase like crazy, and estrogen receptor will overexpress.

And then people feel estrogen even without estrogen being high and SHBG goes up

similar to those who crashed and got PFS from aromatase inhibitors.



So from Jack17 case, we learned this.

 

[joekool]

@Helen couple points of debate

and then when you come off the drug you start hitting this high gaba. which increases prolactin, suppresses dopamine and acetycholine release, and prolactin tells the body to retain calcium

With regards to coming off the drug and this statement regarding gaba, why don't you agree the same happens to Androgen Receptors when the flood of DHT returns?

Since calcium is being retained, body has to switch off estrogen, since estrogen also lowers dopamine and converts it to noradrenaline and increases prolactin. And also retains calcium.

With regards to switching off estrogen, or retaining of calcium, which I recently started saying & using magnesium and K2 to loosen up so I agree with that, don't forget we have more than just the endocrine system damaged so the calcium being retained would affect arteries, bone, heart... everything... if calcium was going 'into the cell' and not coming out, our hearts would seize up.

 

[raven]

After 3 days noticed that my sweat is smelling more healthy. For the past year during my most recent wave of stomach problems my sweat has smelt a bit dull, not bad, just no tanginess, and notably different to how it used to, but that seems to be changing.

 

[Helen]

@Helen couple points of debate



With regards to coming off the drug and this statement regarding gaba, why don't you agree the same happens to Androgen Receptors when the flood of DHT returns?



With regards to switching off estrogen, or retaining of calcium, which I recently started saying & using magnesium and K2 to loosen up so I agree with that, don't forget we have more than just the endocrine system damaged so the calcium being retained would affect arteries, bone, heart... everything... if calcium was going 'into the cell' and not coming out, our hearts would seize up.

What do you mean I don't agree the same happens when DHT returns. I have been saying that AR is overexpressed. also.

and overexpressed in the brain. possible along with progesterone and estrogen.

brain feels too much of DHT action and binds it with SHBG

then prostate does not get DHT into it. and thus penile ARs are all overexpressed. and stay this way.




there is no calcium activation while on finasteride. otherwise JACK17 would feel worse on it and not cured. but he feels cured while on DUTASTERIDE.


Dutasteride lowers DHT levels. and kills 5ARs, but he feels totally cured.


this is why I outlined 2 possibilities why it happens, why he feels cured.

 

[Helen]

@joekool we have fast and slow oxidziers. low and high calcium level people.

It is not about calcium at all. or calcification, since most people are slow oxidizers by the age 35. And tons of them are slow oxidizers with high calcium levels on hairtest.

but none of them have PFS. I dealt with hairtest for a long time.


I think with PFS , the problem is in the brain.

thus the brain just contols SHBG.


Also don't forget that people crash from ONE pill.


in one pill scenario, I don't think receptors would be able to to overexpress at all.

so possible fin just turns off some system which was already weak. may be NADPH system, and crashes methylation,

and then it is very hard to get redox back up. since all b12 gets oxidized.

 

[Seekinghealth]

Speaking about mallasessia restricta and fat digestion.
In my opinion I have always been saying despite disbelieve from my surroundings: "I don't do fat very well" seb. dermatitis scalp etc. I wonder if I have pushed it to much to the other side of things. Dry skin that I can just roll off during one my sweating attacks/hot flashes whatever they might be. Trying to connect this to blood sugar regulation, hence my slightly off-topic comment about blood-values after a meal.

Just for the record lipase enzyme: of 10 U/L [ref. 0-67]

Amylase: 99 U/L [ref. 0-100]

"Are there more members with similair fat-related problems that have amylase or lipase values?"

Anekdote: Even people on diabetic forums are saying: That even a little fat might make their BS elevated for to long. Probaly feeding other fungus. I was eating buckwheat flour pancakes today (300g) Which has roughly 10 grams of fat in total. Yeah rediciulous portions I know, like I said whether it is true or not : "I don't do fat very well".

It stays semi elevated in range for 3 hours: 5.9 (1 hour), 6.6 (2 hours) 6.3 (3 hours). Despite these values good or bad I do feel off.

Will still need to rule out a celiac or other small intestine problem, after a gasto visit next month. As I did/do suffer from a rash similair to dermatitis herpetiformis (DH) that I have gotten in the past. Celiacs are known to have fat-malabsorption problems. Have not had such a rash in a while though. I did not test positive for the DNA snips that should indicate celiac in the past. "They said it would be impossible to have it'

Also going for a check-up for my liver as ALT was slightly elevated before (has been for a very long time more) and now has risen quite a bit and alk.phosphatase is slightly elevated for some time (could indicate possible bile duct issue). Have already gotten 3 Ultrasounds: One I accidentally screwed up by eating (the 3rd) beforehand and though the staff said it behaved weird they did not want to examine it further. The other conclusion I got was that the galbladder was "very small".

But lets say there is a bile problem like Helen said. In my case with elevated serum retinol, it is probaly blocked of some sort as the body will reduce bile and hence the reabsorption of fat-soluable vitamins. Hence me also taking great interest to the Vit A is toxic theory lately.

Ggenereux links DH to vit A. toxity.

In any case Liver/galbladder master organ?

 

[Aleksandr]

One more piece to the puzzle:

Effects of dietary fibers on magnesium absorption in animals and humans. - PubMed - NCBI

TLDR; Enhances magnesium absorption.

 

[Helen]

One more piece to the puzzle:

Effects of dietary fibers on magnesium absorption in animals and humans. - PubMed - NCBI

TLDR; Enhances magnesium absorption.

eat some veggies, they have fiber and magnesium.

Fat in the gut decreases absorbtion of magnesium. and calcium etc. Magnesium Metabolism and its Disorders


resistant starch does not get absorbed in the small intestines. It goes into the colon and ferments there, by fermenting it makes short chain fatty acids, like butyric acid.

Which was mentioned here many times. butyric acid increases gaba action. and also is HDAC inhibitor, so increases acetylation of histones.

 

[JasonSky]

eat some veggies, they have fiber and magnesium.

Fat in the gut decreases absorbtion of magnesium. and calcium etc. Magnesium Metabolism and its Disorders


resistant starch does not get absorbed in the small intestines. It goes into the colon and ferments there, by fermenting it makes short chain fatty acids, like butyric acid.

Which was mentioned here many times. butyric acid increases gaba action. and also is HDAC inhibitor, so increases acetylation of histones.

Do you generally agree with the logic behind this method to help heal the gut? I know in the past you haven't been the biggest fan of probiotics

 

[Helen]

Do you generally agree with the logic behind this method to help heal the gut? I know in the past you haven't been the biggest fan of probiotics

I used probiotics in forms of enemas.

this method is mostly resistant starch. I used it also and also I used okra to lower Sibo.

 

[Helen]

@Helen couple points of debate



With regards to coming off the drug and this statement regarding gaba, why don't you agree the same happens to Androgen Receptors when the flood of DHT returns?



With regards to switching off estrogen, or retaining of calcium, which I recently started saying & using magnesium and K2 to loosen up so I agree with that, don't forget we have more than just the endocrine system damaged so the calcium being retained would affect arteries, bone, heart... everything... if calcium was going 'into the cell' and not coming out, our hearts would seize up.

you need to go to Boris's signature and read electrolytes protocol on Wiki.

it explains everything there. Magnesium Potassium etc

And it has all the things to get rid of heavy metals , calcium deposits etc.

but it is still not personalized.

thiosulphate is the stuff which gets rid of all calcium deposits.

same as epson salts. since they get right into the cell.

taking orally with fat malabsorption could be a problem.

 

[jacknap]

@joekool Now lets look at Jack17's case.

the guy has high DHT, high test, typical slow oxidizer.

He takes dutasteride. and feels totally recovered. totally free of all symptoms.

His 5AR goes down on Dutasteride. He feels recovered while inihbiting 5AR. while on it.


question is This. Do fin and dutasteride, just kills 5AR by some mechanism, or they kill NADPH.

So lets just consider 2 variants.


1) if they kill 5AR by some mechanism, then testosterone goes up, and estrogen goes up, and allopregnenolone goes down, and 3 adiol goes down since these are dependant of 5 ar. , the last 2 switch off gaba.

So in this case we can imagine that gaba receptor will get overexpressed.

and then when you come off the drug you start hitting this high gaba. which increases prolactin, suppresses dopamine and acetycholine release, and prolactin tells the body to retain calcium.

Since calcium is being retained, body has to switch off estrogen, since estrogen also lowers dopamine and converts it to noradrenaline and increases prolactin. And also retains calcium.

but if GABA is already doing this. then estrogen gets closed. and you get unavailable copper.and no estrogen action .


2) second variant, is if Dutasteride, and Finasteride kills NADPH production.

then this will effect aromatase like crazy, and estrogen receptor will overexpress.

And then people feel estrogen even without estrogen being high and SHBG goes up

similar to those who crashed and got PFS from aromatase inhibitors.



So from Jack17 case, we learned this.

I'm sure you already know this but was talking to Ori Hofmekler (Author of warrior diet). He was saying how often times from super high cortisol as well it increaes SHBG and ties up testosterone making it useless. PFS also has a chicken or egg component where you feel like shit so you can't sleep and then stress over lack of sleep and feedback loop happens. Then you lose confidence which puts into further prey state + cortisol / shbg overload. That definitely happened to me. Hence why ashwagandha was/is so potent for me.

 

[jacknap]

.


Joe, the guy is a slow oxidizer with high calcium. So calcium activation . glycine is NDMA receptor agonist.

and slow oxidizer has high gaba action. Glycine puts chloride into the cell. gaba also wants to put chloride into the cell.

this is why glycine can downregulate gaba. which is very bad for fast oxidizers, thus Boris and many other people can't tolerate glycine since fast oxidizers have low gaba action.

You could not tolerate magnesium before, since you were not on testosterone, testosterone, retains iron, and iron increases aldosterone . thus your body is ok with magnesium now.

Glycine actually grows fungus. https://cmr.asm.org/content/25/1/106.full Malassezia

this rings true as I was a fast oxidizer before I crashed and glycine did nothing for my sleep. Possibly even made it worse. Things that helped my sleep though were Alibizia, Ziziphus (for REM), ashwagandha

 

[Helen]

I'm sure you already know this but was talking to Ori Hofmekler (Author of warrior diet). He was saying how often times from super high cortisol as well it increaes SHBG and ties up testosterone making it useless. PFS also has a chicken or egg component where you feel like shit so you can't sleep and then stress over lack of sleep and feedback loop happens. Then you lose confidence which puts into further prey state + cortisol / shbg overload. That definitely happened to me. Hence why ashwagandha was/is so potent for me.

yes, I agree we are considering overexpressed GR receptor https://www.hackstasis.com/threads/upregulated-gr-cortisol-receptor-theory.1648/

 

[Aleksandr]

eat some veggies, they have fiber and magnesium.

Fat in the gut decreases absorbtion of magnesium. and calcium etc. Magnesium Metabolism and its Disorders


resistant starch does not get absorbed in the small intestines. It goes into the colon and ferments there, by fermenting it makes short chain fatty acids, like butyric acid.

Which was mentioned here many times. butyric acid increases gaba action. and also is HDAC inhibitor, so increases acetylation of histones.

Strange that because they say more fat is better for fast oxi .. and yet it decreases ca and mg absorption .. hmm

 

[Helen]

Strange that because they say more fat is better for fast oxi .. and yet it decreases ca and mg absorption .. hmm

malabsorption of fats decrease it, since you dont digest vitamin D

 

[bruschi11]

malabsorption of fats decrease it, since you dont digest vitamin D

So you’d say malabsorption issues are likely a primary cause why there are some people who respond poorly to TEI, ARL... correct?

 

[TubZy]

you need to go to Boris's signature and read electrolytes protocol on Wiki.

it explains everything there. Magnesium Potassium etc

And it has all the things to get rid of heavy metals , calcium deposits etc.

but it is still not personalized.

thiosulphate is the stuff which gets rid of all calcium deposits.

same as epson salts. since they get right into the cell.

taking orally with fat malabsorption could be a problem.

It's also here as well
https://hackstasis.com/threads/electrolyte-protocol-for-improved-health.523/