Calcium-D-Glucarate

[joekool]

One thing I've been investigating is how calcium gets stuck in tissue (such as muscle tissue and penile tissue) from a multitude of negative effects from FIN. Lack of magnesium absorption is one.

Calcium D-Glucarate actually provides the salt for glucuronidation which removes toxins including estrogens that are both previously used E & from external toxins such as xenoestrogens. Vitamin K2 (@tanedout ) provides mobility to calcium. Magnesium is needed as well as D3... further testing shows CDG can actually reduce estrogen receptors, a much needed drop for men who suffered PFS and likely spiked in Estrogen receptors.

Though the dosage should be 1G to 2G daily, it could cause stomach issues... furthermore, it'll provide calcium still which is another way to loosen up and release stuck calcium, an effect I believe can last years post fin.

Some users have experienced better days from PFS symptoms from broccoli which is very high in Calcium D-Glucarate. I'm more inclined to believe this was the benefit other sulphorane.

@tanedout , you're vitamin K thread is related to this calcium thread... I'm planning to add the 4 mentioned above to mobilize calcium and reduce estrogen...

 

[Helen]

@joekool Joe , we were already taking calcium glucarate

It breaks down DHT, also if you did not know, thus I assumed that glucuronidation is low. https://www.hackstasis.com/threads/potential-explanation-for-pfs.1387/#post-43686


and actually some people tested the enzyme which breaks down glucuronic acid, and it was high after quiting fin, so the body does not want to break down DHT

in some cases.

in PFS people have low 3a adiol G. which is glucuronized DHT. body gets rid of DHT using glucuronidation.

glucuronidation and glucuronic acid is made with NAD

So in PFS we saw that the enzymes which breaks down glucuronic acid, is HIGH. and UDP is low which shows you that the glucuronidation enzymes are down.

Calcium glucarate, inhibits enzyme which breaks down glucuronic acid and thus increases glucuronidation


I think @bruschi11 tested this enzyme, after PFS , the enzyme which breaks down glucuronic acid. And it was high

 

[Helen]

@joekool Also since you are investigating glucorinidation, wanted to mention to you that anavar and paracetamol are broken down by this enzyme UDP

Paracetamol we found that took away POIS symptoms in some people. same as anvar while on the drug.

I cycled anavar with 5 people with POIS ( some after fin)

POIS was gone on anavar. but when people came off, POIS was worse.

 

[tanedout]

One thing I've been investigating is how calcium gets stuck in tissue (such as muscle tissue and penile tissue) from a multitude of negative effects from FIN. Lack of magnesium absorption is one.

Calcium D-Glucarate actually provides the salt for glucuronidation which removes toxins including estrogens that are both previously used E & from external toxins such as xenoestrogens. Vitamin K2 (@tanedout ) provides mobility to calcium. Magnesium is needed as well as D3... further testing shows CDG can actually reduce estrogen receptors, a much needed drop for men who suffered PFS and likely spiked in Estrogen receptors.

Though the dosage should be 1G to 2G daily, it could cause stomach issues... furthermore, it'll provide calcium still which is another way to loosen up and release stuck calcium, an effect I believe can last years post fin.

Some users have experienced better days from PFS symptoms from broccoli which is very high in Calcium D-Glucarate. I'm more inclined to believe this was the benefit other sulphorane.

@tanedout , you're vitamin K thread is related to this calcium thread... I'm planning to add the 4 mentioned above to mobilize calcium and reduce estrogen...

CDG is another supplement this guy used in his recovery...

So presumably the drop in estrogen receptors would make us more sensitive to estrogen I guess. I seem to do quite well on estrogenic things, and I recently got some tofu to experiment with that

 

[Helen]

CDG is another supplement this guy used in his recovery...

So presumably the drop in estrogen receptors would make us more sensitive to estrogen I guess. I seem to do quite well on estrogenic things, and I recently got some tofu to experiment with that

UDP enzyme is what metabolizes retinol

 

[joekool]

@tanedout if we dropped Estrogen Receptors, I would think we'd be less sensitive to E, no? But CDG keeps us from getting a double dose of the same estrogen molecule already absorbed...

Copper is fairly estrogenic, you have luck on that?

Estrogen sensitizes the Androgen Receptor which then allows for the uptake of DHT... we get our libido from estrogen...

 

[Helen]

@tanedout just looked at your hairtest. you are fast oxidizer burned out.

Do you do good on B6 and NAD?

 

[Helen]

@tanedout if we dropped Estrogen Receptors, I would think we'd be less sensitive to E, no? But CDG keeps us from getting a double dose of the same estrogen molecule already absorbed...

Copper is fairly estrogenic, you have luck on that?

Estrogen sensitizes the Androgen Receptor which then allows for the uptake of DHT... we get our libido from estrogen...

receptor expression changes VERY FAST density changes amazingly fast and it is never a problem.

ESTROGEN DIRECTLY BLOCKS AND LOWERS ANDROGEN RECEPTORS, since when estrogen is high that means that body wants to retain copper. body thinks there is no SODs, and thus IRON which is retained by androgen receptor is NOT ALLOWED.


Thus if you take ESTROGEN, it will retain copper, then after you quit estrogen, your estrogen will be lower and androgen receptors will be ALLOWED to go up.


This is why if you have high estrogen, and it is always high, it will constanly block your androgen receptors. Body thinks thyroid is fast. it wants to save protein NOT TO DIE and not to build from it using androgens.


But if you take estrogen from outside, your own production falls. afterwards. since the estrogen from the outside, will downregulate estro

 

[HerrFisch]

Maybe Glucuronolactone supplement is something to think about?

 

[wuf]

@joekool Also since you are investigating glucorinidation, wanted to mention to you that anavar and paracetamol are broken down by this enzyme UDP

Paracetamol we found that took away POIS symptoms in some people. same as anvar while on the drug.

I cycled anavar with 5 people with POIS ( some after fin)

POIS was gone on anavar. but when people came off, POIS was worse.

Is paracetamol safe for PFS people?
I have been using it a lot the last month and I don't know it it did something or not in terms of PFS symptoms.

 

[Helen]

Maybe Glucuronolactone supplement is something to think about?

yes, it inhibits B-glucuronidase

 

[Helen]

Is paracetamol safe for PFS people?
I have been using it a lot the last month and I don't know it it did something or not in terms of PFS symptoms.

it screws up the liver eventually. be careful

 

[tanedout]

@tanedout just looked at your hairtest. you are fast oxidizer burned out.

Do you do good on B6 and NAD?

Yeah I think that was my first hair test? Where I was a Fast4? But the second 12 months later I'd changed to a Slow1. I think the biggest factor was avoiding calcium for 2 months prior to the 2nd test.

I've tried B6 and NAD before, and don't remember anything that special from it, but I'll make a note to re-try and let you know.

Interestingly had beef steak meal today, and less than an hour afterwards I have noticeably improved clarity. Colours look more vivid etc. Still not sure why, whether it's the high zinc, or K2 content. Don't get this from other meats. Guess I'll have to try those things in supplement form to find out!

 

[brix]

@Helen what is a burnt out fast oxidizer? 4 lows? 3 lows with high K?

 

[Helen]

Yeah I think that was my first hair test? Where I was a Fast4? But the second 12 months later I'd changed to a Slow1. I think the biggest factor was avoiding calcium for 2 months prior to the 2nd test.

I've tried B6 and NAD before, and don't remember anything that special from it, but I'll make a note to re-try and let you know.

Interestingly had beef steak meal today, and less than an hour afterwards I have noticeably improved clarity. Colours look more vivid etc. Still not sure why, whether it's the high zinc, or K2 content. Don't get this from other meats. Guess I'll have to try those things in supplement form to find out!

I think prior to second test you took potassium and b6. which allowed you to retain calcium


Don't forget that if AR is strong, or DHT is high . this will inhibit VDR receptor and you can have high 1.25D in blood but it is not working. so your calcium is not retained.

this happened with high cortisol. of yours, since cortisol causes alkalosis and if you retain calcium in alkalosis you will get calcified.


So if you took potassium b6 may be zinc, this increased your progesterone which blocked some of the cortisol effect,

and allowed you to retain calcium even though you were not taking it.

Beef has tiny amount of vitamin k

 

[mbax44]

Always liked this supplement. Supposedly helps with Gilbert’s syndrome which I have and many with cfs/pfs type issues have as well.

 

[Helen]

Always liked this supplement. Supposedly helps with Gilbert’s syndrome which I have and many with cfs/pfs type issues have as well.

yeah , we had tons of people with gilberts on POIS forum and it was mainly a reason why some people could recover from PFS and some could not.

https://www.hackstasis.com/threads/potential-explanation-for-pfs.1387/#post-43686

 

[bruschi11]

@joekool Joe , we were already taking calcium glucarate

It breaks down DHT, also if you did not know, thus I assumed that glucuronidation is low. https://www.hackstasis.com/threads/potential-explanation-for-pfs.1387/#post-43686


and actually some people tested the enzyme which breaks down glucuronic acid, and it was high after quiting fin, so the body does not want to break down DHT

in some cases.

in PFS people have low 3a adiol G. which is glucuronized DHT. body gets rid of DHT using glucuronidation.

glucuronidation and glucuronic acid is made with NAD

So in PFS we saw that the enzymes which breaks down glucuronic acid, is HIGH. and UDP is low which shows you that the glucuronidation enzymes are down.

Calcium glucarate, inhibits enzyme which breaks down glucuronic acid and thus increases glucuronidation


I think @bruschi11 tested this enzyme, after PFS , the enzyme which breaks down glucuronic acid. And it was high

Yea beta-glucuronidase or whatever it is was like 10x the limit. It’s a toxin trapper this enzyme when it gets too high.

Within 3.5 months of hard Lyme/Candida/ detox/ fasting treatment in 2017, this enzyme went to low end of range. Even when I got sick again this past year, this enzyme stayed low.

Seems like Finasteride must’ve caused the initial spike.