Can someone try Wormwood to block GABA A receptor and see if you feel recovered.

[Rid]

Interesting timing @Helen, was this at all related to this ph thread? What I believe PSF is

What do you think of this guys theory? I've been following him years and I can vouch for his credibility in his recovery (he recovered through fasting, diet and lifestyle changes mainly) but i have no clue on the science end. He may have solved his issues but obviously that may only translate to some cases, of which he thinks there are 2.

 

[Admiral]

Ordered wormwood and will report back. Safe and easy to try.

 

[Helen]

Interesting timing @Helen, was this at all related to this ph thread? What I believe PSF is

What do you think of this guys theory? I've been following him years and I can vouch for his credibility in his recovery (he recovered through fasting, diet and lifestyle changes mainly) but i have no clue on the science end. He may have solved his issues but obviously that may only translate to some cases, of which he thinks there are 2.

I have been writing about gaba in every single theory of mine for a year already.

only that guy in that thread has it wrong.

people feel totally cured on WORMWOOD. which blocks gaba. A

And other people feel bad on wormwood and better on the rebound.

Read the theories and cases which I outlined, many times.

There is zero DHT in CSF, so 5AR is not working.

without 5AR you can't get to allopregnenolone


The body does not want to convert testosterone into DHT in the brain.

either

1) receptor for DHT is overexpressed and the body closes 5AR, this leads to zero allopregnenolone and closed 5AR

2) 5AR is closed since there is GABA A problem. or progesterone problem.

3) Overexpressed GR causing 3beta hsd suppression, which then forces the body to close 5AR and keep progesterone metabolism to zero.

thus no conversion of testosterone into DHT in the brain

 

[Helen]

@Rid https://www.hackstasis.com/threads/...s-cases-protocols-explanations-theories.1500/

Here I outlined all this stuff.

but now I think GR receptor is involved a lot more than all this other stuff maybe

 

[Ingeno]

Reading all those discussions makes me wonder how TEI/ARL are going to fix all of this receptor stuff. If all our minerals are balanced on a hair test, does this automatically mean we are cured? I find that hard to believe.

 

[talkingant]

Some studies relevant to GABA:

Low dose fluoxetine reverses decrease in allopreg caused by exogenous T. High androgens may downregulate 5aR and 3aHSOR enzymes, reducing allo and thus downregulating GABA-A. Fluoxetine can increase allo content at a low dose that does not cause serotonin reuptake inhibiton.


Effect of GABA on Neurosteroid Biosynthesis

The inhibitory effect of GABA on neurosteroid production is mimicked by the GABA-A receptor agonist muscimol and is blocked by the selective GABA-A receptor antagonists bicuculline and SR95531, but is not affected by the GABA-B receptor agonist baclofen. The observation that bicuculline and SR95531 induce on their own a significant stimulation of steroid formation suggests that endogenous GABA exerts a tonic inhibitory control on neurosteroid-producing neurons. These data indicate that GABA inhibits the biosynthesis of neurosteroids through activation of GABA-A receptors (Figure 1D). Since several neuroactive steroids are potent allosteric regulators of GABA-A receptor function in amphibians as in mammals, these observations reveal the existence of an ultrashort feedback loop through which certain neurosteroids may regulate their own production via modulation of GABA-A receptor activity.

 

[Ocguy]

Reading all those discussions makes me wonder how TEI/ARL are going to fix all of this receptor stuff. If all our minerals are balanced on a hair test, does this automatically mean we are cured? I find that hard to believe.

The question is will we ever get perfectly balanced with the right ratios as long as pfs is an issue? I know the closer I got the better I felt.. although I've see people very sick with cancer and minerals all over the place but they have libido.. so the way to look at it is our bodies have an individual journey to heal..
even if somebody has a better or worse or even the same mineral profile doesn't mean theyre struggling with the same issue.. all we're doing is trying to put the body in a state of healing..

 

[Blugrass]

I'm currently experimenting with Quercetin. I feel terrible, sleepy, and agitated for like 6 hours. But after that the feeling is incredible for the entire day. So much better than baselin.

It says here that quercetin is an antagonist to one type of gaba a receptor

Quercetin antagonism of GABAAρ₁ receptors is prevented by ascorbic acid through a redox-independent mechanism. - PubMed - NCBI

But quercetin also makes cortisol receptors more sensitive maybe by lowering cortisol temporarily. It does that by lowering iron (which I learned from @Helen)

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

So I'm not sure which mechanism is helping me. Cortisol or gaba.

Does wormwood have the same effect on cortisol?

 

[freeflow]

I think its your GABA receptors man. I also feel much better than baseline in the other half of the day after wormwood.

 

[Blugrass]

Maybe both gaba and cortisol go hand in hand. Who knows.

But yeah I feel awesome on the snap back from quercetin, I'm so much friendlier lol.

I need more trials to tell if it's helping sexually, but I think it does

 

[freeflow]

Maybe both gaba and cortisol go hand in hand. Who knows.

But yeah I feel awesome on the snap back from quercetin, I'm so much friendlier lol.

I need more trials to tell if it's helping sexually, but I think it does

It does help me not just sexually, but emotion wise and strength, muscle wise too.

 

[RebelWithACause]

The question is will we ever get perfectly balanced with the right ratios as long as pfs is an issue? I know the closer I got the better I felt.. although I've see people very sick with cancer and minerals all over the place but they have libido.. so the way to look at it is our bodies have an individual journey to heal..
even if somebody has a better or worse or even the same mineral profile doesn't mean theyre struggling with the same issue.. all we're doing is trying to put the body in a state of healing..

Well minerals also influence GABA, cortisol, progesterone etc.

 

[freeflow]

Maybe both gaba and cortisol go hand in hand. Who knows.

But yeah I feel awesome on the snap back from quercetin, I'm so much friendlier lol.

I need more trials to tell if it's helping sexually, but I think it does

Why dont you try 3 days or 1 week of quercentin taken 3 times a day: morning-noon-evening. SO you block the GABA for many days and expect a much stronger snap back after many days of blockage.

 

[Helen]

Why dont you try 3 days or 1 week of quercentin taken 3 times a day: morning-noon-evening. SO you block the GABA for many days and expect a much stronger snap back after many days of blockage.

gaba controls the release of CRH and cortisol. SO high gaba decreases cortisol release.

Has been trying wormwood for 2 days to see what it does. Makes me hyper super libido while on it, when it wear off total gaba state- no libido, sweating more. CO2 higher, feels like on benzo.

Big question here is if it activates CB1 receptor. since it kinds of felt like it does( reminded me of weed a little). CB1 receptor controls LH release.


quercetin - the opposite. Feels like benzo on it. Totally sleepy. Feels like GABA supplement.

 

[Helen]

Maybe both gaba and cortisol go hand in hand. Who knows.

But yeah I feel awesome on the snap back from quercetin, I'm so much friendlier lol.

I need more trials to tell if it's helping sexually, but I think it does

quercetin effects acetylcholine system and thus aluminum balance.

Since we know you are toxic in aluminum, may be it does something to acetylcholine.

 

[freeflow]

gaba controls the release of CRH and cortisol. SO high gaba decreases cortisol release.

Has been trying wormwood for 2 days to see what it does. Makes me hyper super libido while on it, when it wear off total gaba state- no libido, sweating more. CO2 higher, feels like on benzo.

Big question here is if it activates CB1 receptor. since it kinds of felt like it does( reminded me of weed a little). CB1 receptor controls LH release.


quercetin - the opposite. Feels like benzo on it. Totally sleepy.

Lol, i just have the brain pressure, fog, agitation and noise sensitivity. For how long do you feel the wormwood effects after taking?
I take 1 capsule in the morning: 425 mg Swanson brand, and feel shit for 3-5 hours. The snapback comes in 7-9 hours.

 

[Helen]

Lol, i just have the brain pressure, fog, agitation and noise sensitivity. For how long do you feel the wormwood effects after taking?
I take 1 capsule in the morning: 425 mg Swanson brand, and feel shit for 3-5 hours. The snapback comes in 7-9 hours.

I feel super high libido, energy and mood for 3-5 hours, and then sudden drop and feel like on benzo for 9 hours))


it it effects CB1 receptor , that is not good for me since, I always felt like I wanted CB1 stronger.

Remember the study Koreans or Japanese did on POIS. They found that POIS was like cannabis withdrawal.

And on the poiscenter, we got tons of people who got POIS from smoking pot and then quitting.


But I read that wormwood could attach to CB1 receptor but it does nothing about it. SO may be actually upregulates the CB1 receptor. IT does have affinity to the receptor , but it does nothing no cannabinoid effects, so may be it makes the receptor stronger. I am not sure.


As I wrote in the theory about PFS POIS that CB1 receptor can play a part also. Since they found pregnenolone being low in CSF. and pregnenolone is what controls CB1.

 

[freeflow]

I feel super high libido, energy and mood for 3-5 hours, and then sudden drop and feel like on benzo for 9 hours))


it it effects CB1 receptor , that is not good for me since, I always felt like I wanted CB1 stronger.

Remember the study Koreans or Japanese did on POIS. They found that it was like cannabis withdrawal.

And on the poiscenter, we got tons of people who got POIS from smoking pot and then quitting.

Interesting. So for me it seems good though? The timeframes look the same too.

 

[Helen]

Interesting. So for me it seems good though? The timeframes look the same too.

read the previous post I added there.

 

[Goose12]

Just wanted to mention some herbs that are being talked about and how they affected me.

I took wormwood for a couple of months straight when I first crashed. It was the only thing that really improved my digestion and got rid of my constant liver/ gallbladder pressure. I didn't notice any improvements on other symptoms but I was at my worst after I crashed.

It would usually take two to three days to kick in. It improved my symptoms while and would leave me slightly better off.

Licorice root lead to me crashing again. It took a long time to recover from that crash.

Ashwagandha, I didn't notice much on but I would get spurts in labido a day or two after. Same with tongkat Ali.

Ginko Balboa helped with anxiety.

Tribulus brings back morning wood and some labido. Would keep some gains after high dose cycling.