CONNECTION LICORICE, INOSITOL, RU, ELLA, PROGESTERONE,LITHIUM

[ruprmurdoch]

Guys, need clarification. Ru and Ella, decrease level of cortisol while you take it. In the same time it increase adrenaline. Is this statement correct?

If not please explain, im not sure whether i understand correctly, mechanism of this substances action.

 

[IHateFin]

Guys, need clarification. Ru and Ella, decrease level of cortisol while you take it. In the same time it increase adrenaline. Is this statement correct?

If not please explain, im not sure whether i understand correctly, mechanism of this substances action.

I don't know about ella, but I have seen it doesn't bind to the GR (glucocorticoid receptor), but RU486 will and it has 18 times the affinity for the GR than cortisol. this blocks cortisol from activating the receptor and will cause an increase in ACTH and cortisol and if blockage is great enough ( which is not hard to do) the body will increase adrenaline since that will quickly trigger a release in cortisol. the body senses that it is low in cortisol due to cort not being able to reach receptors when being blocked by ru486.

 

[Shadow]

Ella binds to GR too, but its a lot weaker than RU486.

In addition to its effects on human progesterone receptors, ulipristal acetate binds to glucocorticoid and androgen receptors. However, its capacity as an antagonist in binding to these receptors is markedly lower than its anti-progestational activity. Anti-glucocorticoid and anti-androgen activities were observed at doses 50-fold greater than that necessary for an anti-progestin effect, indicating that ulipristal acetate is a progesterone receptor modulator with reduced anti-glucocorticoid activity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138379/

 

[ruprmurdoch]

Guys i asked this question, elswhere, but what levels of progesterone are considered as high in males???

 

[Ghost]

IK this thread is a bit dead, but this seemed the best place to put this.

In regards to Licorice, it blocks 11B-HSD from converting Cortisol to Cortisone. Now, this is really important for its role with Aldosterone. Cortisol binds to the GR, but also to the MR. Without 11B-HSD, Cortisol would overwhelm the MR and lead to a chronic state of pseudo-aldosteronism and tank k+ / do the other things that happen on licorice. 11B-HSD is present by MRs so that it can attempt to block cortisol action on it. What if licorice suppressing 11B-HSD induces the body to freak out and increase 11B-HSD expression? Then you'd stop the licorice, and bounce back because you would have lowered Aldosterone on the Licorice, and now you'd also block more cortisol on the MR. This might be another factor that allows a snap-back after Licorice treatment.

 

[Helen]

IK this thread is a bit dead, but this seemed the best place to put this.

In regards to Licorice, it blocks 11B-HSD from converting Cortisol to Cortisone. Now, this is really important for its role with Aldosterone. Cortisol binds to the GR, but also to the MR. Without 11B-HSD, Cortisol would overwhelm the MR and lead to a chronic state of pseudo-aldosteronism and tank k+ / do the other things that happen on licorice. 11B-HSD is present by MRs so that it can attempt to block cortisol action on it. What if licorice suppressing 11B-HSD induces the body to freak out and increase 11B-HSD expression? Then you'd stop the licorice, and bounce back because you would have lowered Aldosterone on the Licorice, and now you'd also block more cortisol on the MR. This might be another factor that allows a snap-back after Licorice treatment.

this is exactly the mechanism I posted before for licorice. I thought we talked about, remember you and I. Since in PSSD, you guys seem to have high aldosterone, and it is not the same as for PFS people.

there is a fork where you have high aldo and high progesterone in PSSD, this does not allow you to retain potassium no sodium. You need to break on leg of this fork , and retain one side. and then the body will manage to retain another leg.

Licorice will retain sodium and this will tank aldo. then you quit licorice and body will be able to retain potassium since aldo will be already down after licorice.

 

[Jaxx]

how would this work in a combination with ella? Combining it both at the same time or start ella when quiting licorice?

 

[Ghost]

this is exactly the mechanism I posted before for licorice. I thought we talked about, remember you and I. Since in PSSD, you guys seem to have high aldosterone, and it is not the same as for PFS people.

there is a fork where you have high aldo and high progesterone in PSSD, this does not allow you to retain potassium no sodium. You need to break on leg of this fork , and retain one side. and then the body will manage to retain another leg.

Licorice will retain sodium and this will tank aldo. then you quit licorice and body will be able to retain potassium since aldo will be already down after licorice.

We talked about the idea and the fork, but I don't recall talking about 11B-HSD in particular. The 11B-HSD is what I’m suggesting here, and I agree with the k+/Na+ stuff from our conversation. In fact, I know we didn’t talk about 11B-HSD because I just searched the entire thread for the keyword “11B” and it came up with no hits. Maybe you have posted about it before, but I had no hits on the forum-wide search either (but I’ll note that I’ve seen that system to be flawed before). I’m suggesting that the problem could be in the function of this enzyme and that this might be an interesting lead in particular.

 

[Helen]

We talked about the idea and the fork, but I don't recall talking about 11B-HSD in particular. The 11B-HSD is what I’m suggesting here, and I agree with the k+/Na+ stuff from our conversation. In fact, I know we didn’t talk about 11B-HSD because I just searched the entire thread for the keyword “11B” and it came up with no hits. Maybe you have posted about it before, but I had no hits on the forum-wide search either (but I’ll note that I’ve seen that system to be flawed before). I’m suggesting that the problem could be in the function of this enzyme and that this might be an interesting lead in particular.

11 b HSD. Licorice blocks this enzyme and raises cortisol. this is why I suggested it. this increased cortisol retains sodium which lowers aldosterone. Then you get off licorice. 11 b hsd goes back online. And cortisol falls, and aldo is still low since sodium is retained. Now you can retain potassium. This is how it works on the snap back/

Much easier is to go and just get an IV with sodium chloride and potassium chloride. FIXED in 1 day.


How are you doing ? are you finished with the licorice cycle?

 

[Shadow]

11 b HSD. Licorice blocks this enzyme and raises cortisol. this is why I suggested it. this increased cortisol retains sodium which lowers aldosterone. Then you get off licorice. 11 b hsd goes back online. And cortisol falls, and aldo is still low since sodium is retained. Now you can retain potassium. This is how it works on the snap back/

Much easier is to go and just get an IV with sodium chloride and potassium chloride. FIXED in 1 day.


How are you doing ? are you finished with the licorice cycle?

I tried to get the IV done, but its more difficult than I thought

 

[Canari]

I tried to get the IV done, but its more difficult than I thought

Do you mean your doctor does not accept to get it done to you?

 

[Ghost]

11 b HSD. Licorice blocks this enzyme and raises cortisol. this is why I suggested it. this increased cortisol retains sodium which lowers aldosterone. Then you get off licorice. 11 b hsd goes back online. And cortisol falls, and aldo is still low since sodium is retained. Now you can retain potassium. This is how it works on the snap back/

Much easier is to go and just get an IV with sodium chloride and potassium chloride. FIXED in 1 day.


How are you doing ? are you finished with the licorice cycle?

I'm kinda back to where I was before it. For a while it increased anxiety a lot, but that went away. I think that because I was taking a lot of exams that it took my anxiety and amplified that. Because I'm prone to anxiety, it all created the perfect storm. It took the anxiety a while to calm down after, but I think it's back to baseline. In general I may not have the most severe symptoms. I've had sex since licorice and it went fairly well, but obviously I lack the sensitivity and full hardness that I had before this.

I'd be open to another cycle, but want to try the Zinc Finger protocol done first. I'm going to do a lot more lab testing to get a better picture of what I need to fix.

 

[Shadow]

Do you mean your doctor does not accept to get it done to you?

No because he want to see a new test of Aldosterone, Potassium and PRA first...