Corpus Cavernosum Fibrosis

[Crashing]

Cialis causes huge spikes in cortisol that damage one's brain. I think low-dose viagra before bedtime would be safer. Or if you take cialis, couple it with high dose phosphatidylserine before bedtime to protect your brain from too much cortisol.

 

[Niles]

Cialis causes huge spikes in cortisol that damage one's brain. I think low-dose viagra before bedtime would be safer. Or if you take cialis, couple it with high dose phosphatidylserine before bedtime to protect your brain from too much cortisol.

That's an exaggeration. Tadalafil has been shown to affect cortisol levels when taken in the 20mg range and before "maximal exercise", but the same effect on cortisol has not been shown under normal conditions, let alone with the <5mg EOD dosages suggested here for penile fibrosis. And if you're worried about side effects, why would you look to viagra as an alternative? Cialis has a far safer profile...

 

[Crashing]

That's an exaggeration. Tadalafil has been shown to affect cortisol levels when taken in the 20mg range and before "maximal exercise", but the same effect on cortisol has not been shown under normal conditions, let alone with the <5mg EOD dosages suggested here for penile fibrosis. And if you're worried about side effects, why would you look to viagra as an alternative? Cialis has a far safer profile...

why would there be any difference between 5mg daily and 20mg every 3 days? The steady-state blood levels of tadalafil should be the same, no?

 

[Niles]

why would there be any difference between 5mg daily and 20mg every 3 days? The steady-state blood levels of tadalafil should be the same, no?

In the studies I've seen, the 20mg was administered 8hrs before stress test, and higher cortisol levels were observed immediately after exercise in the tadalafil group vs. placebo group. 8hrs after administration of 20mg, one would have higher serum concentration than at any point during a 5mg EOD regimen.

 

[Niles]

I should mention that I am very sensitive to fluctuations in cortisol, and going on 5mg tadalafil EOD hasn't affected my cortisol issues either positively or negatively.

 

[Crashing]

it hasn't ever affected the quality of your sleep?

 

[Niles]

it hasn't ever affected the quality of your sleep?

First time I tried it, I tried 10mg and did get the headache/stuffy nose symptoms that are often reported, and the discomfort from that alone did slightly affect my sleep. After lowering to 5mg I've had no problems at all, but still get good intended effects.

I think 5mg is my sweet spot, but others have had success with as little as 2.5mg.