Cycling Dopamine Inhibitors?

tanedout

Well-Known Member
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538
So has anyone really given this a shot? I think dopamine is a big factor in a lot of cases of PFS/PAS/PSSD. In my case I've had periods of sensitivity returning when using things which increase dopamine. CDP Choline to an extent, lots of green tea is noticeable and weed fairly consistently, but I don't like touching the stuff and the benefit is only when under the influence of it. I read a comment on this article about someone else who gets a noticeable boost from weed;

I found that Cannabis (or a complex prescription and OTC combination of MJ's equivelant) is the perfect fit for me, (though it counts as a street drug in some places), as it raises dopamine and lowers serotonin (beyond low doses) while raising acetylcholine, essentially making me calm, happy, and able to think faster and clearer than usual

Dopamine: Serotonin's Secret Weapon

A number of people on PAS forums have seen brief recoveries using things that increase dopamine. L-dopa, St Johns Wort and a few other things, but it seems increasing potentially already up-regulated receptors doesn't work for long, and the benefits fade, but then there are people who have gone the other way and cycled licorice extract which inhibits dopamine - this PFS recovery is what I'm thinking;

Orginally posted by Champster:

I don't think I can edit the title but obviously I mean boost your LOW T (*SoCal Edited This For you)

I say that I'm a 'lurker' but I actually didn't know that this forum existed until only a few days ago. But I would refer to the cdnuts recovery thread on propeciahelp while I was struggling with my health. Here's my story:

2012-2013: using finasteride
January 2014: quit finasteride because of lowered libido, had extremely high libido for a few weeks, then I crashed

PFS symptoms: zero libido (none at all), numb genitals, shrunken genitals, depression

2014: trudging along in life with all these pfs problems, really had no idea what was going on
2015-2016: started the cdnuts/boost your lot T protocol.

First did a four week juice feast and then started on a paleo diet with the supplements. Then I added in T boosting herbs, usually 10-12 of them which I rotated daily. I started carb backloading at the same time I started the T boosters. Then I started doing DHT prohormone cycles followed by PCT. In the middle of 2016 I started adding coffee in to my routine and my recovery really started ramping up. My depression that I had some days basically disappeared instantly at this time! I was feeling happier, more motivated, more social. I was doing better at work and in my personal relationships. I was so excited that the protocol was starting to work for me. I still had zero libido and numb genitals but I kept on the protocol because I new it could take time to heal.

At the end of 2016 I started researching around and I found that many PSSD sufferers had the exact same specific symptoms as me: zero libido and numb genitals. And I found that many PSSD sufferers recovered using a natural herb, licorice root. I knew I had PFS and not PSSD since I had never taken SSRI's but the symptoms these guys were describing were very similar to mine. I did a lot of research on the safety profile of the herb and then finally decided to add it to the cdnuts/boost your low T protocol. I started out just trying it on the weekends to see how I would react. I tried it one Saturday and felt kind of bad and I stopped taking it the next day. On Tuesday of that week I had what seemed like a miracle to me. The numbness down there went away for like 10-12 hours. I was shocked as I hadn't felt that in years! The next weekend I took the herb on Saturday and Sunday. Sure enough on Wednesday of that week the numbness started to go away and this time I could feel an actual libido! Once again I hadn't felt something like that in years! It was like something had switched on in my brain and it lasted about 36 hours.

So I continued playing around with this on the weekend and after a few weeks the numbness was pretty much gone and stopped coming back. I worked up to taking 1/4 teaspoon of 4:1 licorice root extract powder dissolved in a mug of hot water three times a day on Saturday and Sunday. I kept taking my T boosters and kept on my paleo diet with carb backloading. Kept working out and focusing on maintaining a positive mindset. And every time in the middle of the week I would get a raging libido again like I was a teenager! Once I had worked up to this dosage, my libido started to stay at a higher level each week. It would increase in the middle of the week, then it would fall down a bit but it stopped falling back down to how I felt during my pfs years. I started feeling like a normal human being for once! Things stopped swinging between superhuman sex starved teenager libido and complete eunuch zero libido. It just stayed at a consistent level through the week and It actually stopped mattering when I took the herb. I wouldn't feel any change.

One weekend arrived and I just never took the licorice root extract again and I've been living life ever since then. I stick to my diet and workout routine during the week but I'm back to beer and pizza with the guys on the weekend
smile.png
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I'm so happy to say that the cdnuts protocol really works. It took me over two years and there wasn't a lot of progress in the beginning. But I hit a major upswing in the middle where my depression really seemed to get better. And then right around 2-2.5 years I finally got my libido back.

I think keeping faith in God really helped me along the way too.

It's really true that once you start making progress with sexual sides, it's like you make a big improvement, then you have a set back, then more improvement, and so on, until everything levels out.

Best of luck everyone!!!

Recoveries - Page 3

I've recently tried licorice root tea a couple of weekends in a row and have felt like shit for 2-3 days after it both times, but then I did get a slight boost in libido after 4-5 days. I need to try more to be sure, but I've decided first I'm going to get another hair sample sent off and do a month at least of TEI, but then I plan to cycle licorice root tea. (I'm currently totally unable to tolerate calcium, so I want to try and fix this imbalance first)

Has anyone followed this method? Or any other methods which use things to inhibit dopamine for a time, then stop to get a 'rebound'?
 
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vicecaz

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256
Never tried CDP-Choline ( was planning to ) or SJW but I did try L Dopa as Mucuna pruriens from CDnuts rotation of herbs . Love the herbs but didn't notice much from it compared to cordyceps Militaris for example ( whose profile is getting more and more interesting the deeper I dig into it ) . Wish I could try a real extract of cordyceps Sinensis .
As you know I already tried the Cannabis oil, RSO method of extraction but hated it .

And I started cycling Licorice root Tea ( same brand and dosage as Champstar in his recovery ), a few weeks after my R andro cycle in August so about 5 dose until now . You seem to have the same snapback as him but for me it was more like feeling really bad almost immediately after ingesting licorice, and getting better two days after, sometimes faster
 

Jaxx

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683
Licorice root was used for pssd by many, but to boost cortisol (or affect estrogen perhaps), not to inhibit dopamine....
 
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MNK99

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5,560
Dopamine owns serotonin.

Don't inhibit dopamine unless you have schizophrenia. I don't think choline inhibits dopamine. Maybe it does, but like d-agonists, improves my mood... and both can make me a bit hypo and more hyper... but also control wtf it is I'm doing... like plan an entire day or month better ---> To an extent. Still get too "up" a bit... but just take something else to sleep like vitamin c, or exercise, or see a friend, or date, or... wait till tired.
--Actually: ** Falling asleep easily these days on TEI***. It's very good. Excellent.

This seems like thinking SSRI's or whatever permanently downregulate serotonin which I don't think is true, and I never did, when recovered. HOWEVER*, it definitely messes with a lot of things.
 
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tanedout

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Messages
538
And I started cycling Licorice root Tea ( same brand and dosage as Champstar in his recovery ), a few weeks after my R andro cycle in August so about 5 dose until now . You seem to have the same snapback as him but for me it was more like feeling really bad almost immediately after ingesting licorice, and getting better two days after, sometimes faster

Keep is posted on that! Do you have high or low cortisol? I've tried this in the past using Now brand licorice root extract and I noticed nothing at all, but the tea seems stronger.

@Jaxx so I'm guessing PSSD people were trying to increase cortisol when it was low, rather than try and increase already high cortisol, so they down-regulate their up-regulated receptors when they stop?
 

Jaxx

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Messages
683
Keep is posted on that! Do you have high or low cortisol? I've tried this in the past using Now brand licorice root extract and I noticed nothing at all, but the tea seems stronger.

@Jaxx so I'm guessing PSSD people were trying to increase cortisol when it was low, rather than try and increase already high cortisol, so they down-regulate their up-regulated receptors when they stop?
It was basically increasing low cortisol, which only works for a short time. It also gave me strong erections in the first week, but that effect went away soon.
 

Area-1255

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Staff member
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1,043
Never tried CDP-Choline ( was planning to ) or SJW but I did try L Dopa as Mucuna pruriens from CDnuts rotation of herbs . Love the herbs but didn't notice much from it compared to cordyceps Militaris for example ( whose profile is getting more and more interesting the deeper I dig into it ) . Wish I could try a real extract of cordyceps Sinensis .
As you know I already tried the Cannabis oil, RSO method of extraction but hated it .

And I started cycling Licorice root Tea ( same brand and dosage as Champstar in his recovery ), a few weeks after my R andro cycle in August so about 5 dose until now . You seem to have the same snapback as him but for me it was more like feeling really bad almost immediately after ingesting licorice, and getting better two days after, sometimes faster
CDP-Choline is fucking' Weird! Its a got a strangely INTENSE libido-increasing Effect. Yet neither Alpha-GPC, nor Uridine, nor any other "mixed-Cholinergic-Dopaminergic" does that For Me?
 

Area-1255

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Because your are incresing dopamine via other pathway, I dont remember the exact name but was pfs related, related to last study of hypocampus, etc.. sometjing about nicotinic receptors
Interesting. But Nicotine actually KILLS my libido despite increasing DHT & lowering E2...most likely because it causes vasoconstriction and reduction of Nitric-Oxide in the Brain!!! Your brain NEEDS nitric-oxide + Dopamine to have libido!