Cyclosporine and brain 5AR

IHateFin

IHateFin

Moderator
Messages
1,156
Greater conversion of testosterone to 5 alpha-dihydrotestosterone, reflecting increased peripheral 5 alpha-reductase activity in nude mice treated wi... - PubMed - NCBI

Has any one looked at this? I saw this mentioned in ray peat a while ago and someone had great improvements on propecia help but never ended up posting how he did after a while. I emailed him so I hope he gets back to me and it worked like a charm.

I also feel like I read that this cured someone else who got it prescribed after they injured their arm or something.

The thought behind this is when we get sick like with the flu and our immune system lowers we feel remission of symptoms. I found a source of this stuff and wonder how useful it could be.
It increases 5AR where it matters (in the brain and CNS) one of the broken feedback loops thanks to draining GABAneric nurosteroids with fin use.

Just wanted to see what you guys thought and if you have also heard of recoveries using immunosuppressive drugs like this one in particular.

"In addition to 5 alpha-DHT, enhanced formation of delta 4-androstenedione (delta 4), 5 alpha-androstan-3 beta,17 beta-diol (3 beta-diol) and 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol) were also observed in the treated groups. These results show a significantly increased formation of 5 alpha-DHT (and Adiol) in nude mice treated with high dose-levels of CsA."
 
F

Flynn

Well-Known Member
Messages
207
This is interesting. From the link you posted though, how do you know this increases 5AR in the brain and CNS??? I don't see this mentioned anywhere.

Taking immunosuppressants is fairly dangerous as they are pretty serious drugs. But if a substance was able to cross the blood brain barrier and increase 5AR expression in the brain. It would be well worth researching. I guess the issue here, is whether it increases 5AR activity or expression. I think the expression needs to be increased.
 
IHateFin

IHateFin

Moderator
Messages
1,156
Flynn said:
This is interesting. From the link you posted though, how do you know this increases 5AR in the brain and CNS??? I don't see this mentioned anywhere.

Taking immunosuppressants is fairly dangerous as they are pretty serious drugs. But if a substance was able to cross the blood brain barrier and increase 5AR expression in the brain. It would be well worth researching. I guess the issue here, is whether it increases 5AR activity or expression. I think the expression needs to be increased.
Click to expand...

From what I have read it's upregulation in expression in the brain. I'll have to sit down n pull some of my findings when I get home from work to see what I have that I've read.

Some reports are anecdotal too. Guy on propecia help who had crippling brain fog was prescribed this and was the only thing that gave him relief. LDN made him worse.
He seemed to have made a ton of recovery even in sexual sides, but stopped giving updates on the thread. So for all we know it could have killed him aha
 
TubZy

TubZy

Well-Known Member
Staff member
Messages
2,591
We did look into this before the RPF thread was deleted. Travis also talked how cyclo is associated with electrolytes as well (potassium/sodium channels etc.), but side effects seem scary and it seems like a bandaid more than anything. If you do more research on it, cyclo regrows hair like crazy too.
 
bruschi11

bruschi11

Administrator
Staff member
Messages
3,000
Yea Grey Baron on PH/solve tried this. Minor success while on drug but nothing after coming off.
 
IHateFin

IHateFin

Moderator
Messages
1,156
bruschi11 said:
Yea Grey Baron on PH/solve tried this. Minor success while on drug but nothing after coming off.
Click to expand...

Ah gotcha! I was hoping to know the ultimate outcome on this. I emailed him too, but I figured it most likely didn't cure him since I'm sure he would be posting a huge update on it in that thread if that were the case
 
You must log in or register to reply here.