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heavy drugs like that usually cause a problem with methylation and demethylation processes. thus there is hypo and hypermethylation going on.
This happens since these drugs effect the redox status in the cell, and redox status control availability of ascorbate which is a cofactor of all these processes.
Finasteride by impairing redox, causes severe oxidative stress, which impairs glutathione, and as per multiple tests we see that redox and reduces glutathione is very very low in PFS people,( you can find these tests on propecia help., there at least 20 people who tested this)
As the redox status is impaired, this impairs Glutathionie Ascorbate cycle Glutathione-ascorbate cycle - Wikipedia
Which basically lowers the levels of active reduced Ascorbate in the cell. now you have high DHA which is oxidized ascorbate.
Active reduced ascorbate is a cofactor for demethylating enzymes which take off methyl group . TET Regulation of the Epigenome by Vitamin C and also active ascorbate is what prohibits BH4 from oxidation thus increases methylation.
The process of methylation and demethylation is an ongoing process. It is constantly flowing.
Basically in PFS there is a heavy hypomethylation going since redox is impaired, but at the same time, when you took a drug, the body overmethylated some DNA parts.
So as you can see, methylation is impaired and Demethylation is also imparied when redox is impaired and this is why the body cant get back to normal on its own.
This is why methylation protocol helped so many people on propeciahelp to feel ALMOST normal and have erections and etc.
SO to be clear again. you take the drug, and the body overmethylates some DNA to support that drug. This drug influences redox process, mainly glutathione recycling process. This impairs both methylation and demethylation.
SO now the body cant get back to normal, since it cant methylate or demethylate these changes.
This is why I suggested the electrolytes protocol, Electrolytes protocol supports glutathione and restores the redox in the cell, which restores methylation and demethylation .
To methylate properly you need b vitamins, proteins, etc. to demethylate properly you need ASCORBATE in the cell. ASCORBATE Is a cofactors of TET enzymes that demethylate . Thus if redox in the cell is impaired , demethylation is impaired. and control of demethylation is impaired Regulation of the Epigenome by Vitamin C
I did use some demethylating agents like sulphoraphane etc and they helped . and some people used demethylation agents on propecia forum even drugs, they felt better but then it all came back. Since you cant control demethylation once, you have to constantly methylate and demethylate
Even if you use demethylating agents, you have to restore redox, otherwise ascorbate will not be there and methylation and demethylation will not work.
Ascorbate loss is the reason some people get EBV post finasteride. Since it is ascorbate which controls viral replication.
Also ascorbate is what support BH4. without BH4 you dont have eNOS. and endothelian disfunction ( erections, circulation problems) and without Bh4 you have no methylation.
here is the article that shows that when ascorbate goes down. It pushes all the processes to happen that we see in PFS
NADPH oxidase activation ( thus we see low b2)
iNOS activation, ( we see no nitric oxide)
Lipid peroxidation.
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury
I hope this is more clear to people, how important it is to restore ASCORBATE which control demethylation ( TET enzyme ) and methylation ( BH4) and Nitric oxide thru Bh4.
This happens since these drugs effect the redox status in the cell, and redox status control availability of ascorbate which is a cofactor of all these processes.
Finasteride by impairing redox, causes severe oxidative stress, which impairs glutathione, and as per multiple tests we see that redox and reduces glutathione is very very low in PFS people,( you can find these tests on propecia help., there at least 20 people who tested this)
As the redox status is impaired, this impairs Glutathionie Ascorbate cycle Glutathione-ascorbate cycle - Wikipedia
Which basically lowers the levels of active reduced Ascorbate in the cell. now you have high DHA which is oxidized ascorbate.
Active reduced ascorbate is a cofactor for demethylating enzymes which take off methyl group . TET Regulation of the Epigenome by Vitamin C and also active ascorbate is what prohibits BH4 from oxidation thus increases methylation.
The process of methylation and demethylation is an ongoing process. It is constantly flowing.
Basically in PFS there is a heavy hypomethylation going since redox is impaired, but at the same time, when you took a drug, the body overmethylated some DNA parts.
So as you can see, methylation is impaired and Demethylation is also imparied when redox is impaired and this is why the body cant get back to normal on its own.
This is why methylation protocol helped so many people on propeciahelp to feel ALMOST normal and have erections and etc.
SO to be clear again. you take the drug, and the body overmethylates some DNA to support that drug. This drug influences redox process, mainly glutathione recycling process. This impairs both methylation and demethylation.
SO now the body cant get back to normal, since it cant methylate or demethylate these changes.
This is why I suggested the electrolytes protocol, Electrolytes protocol supports glutathione and restores the redox in the cell, which restores methylation and demethylation .
To methylate properly you need b vitamins, proteins, etc. to demethylate properly you need ASCORBATE in the cell. ASCORBATE Is a cofactors of TET enzymes that demethylate . Thus if redox in the cell is impaired , demethylation is impaired. and control of demethylation is impaired Regulation of the Epigenome by Vitamin C
I did use some demethylating agents like sulphoraphane etc and they helped . and some people used demethylation agents on propecia forum even drugs, they felt better but then it all came back. Since you cant control demethylation once, you have to constantly methylate and demethylate
Even if you use demethylating agents, you have to restore redox, otherwise ascorbate will not be there and methylation and demethylation will not work.
Ascorbate loss is the reason some people get EBV post finasteride. Since it is ascorbate which controls viral replication.
Also ascorbate is what support BH4. without BH4 you dont have eNOS. and endothelian disfunction ( erections, circulation problems) and without Bh4 you have no methylation.
here is the article that shows that when ascorbate goes down. It pushes all the processes to happen that we see in PFS
NADPH oxidase activation ( thus we see low b2)
iNOS activation, ( we see no nitric oxide)
Lipid peroxidation.
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury
I hope this is more clear to people, how important it is to restore ASCORBATE which control demethylation ( TET enzyme ) and methylation ( BH4) and Nitric oxide thru Bh4.
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