heres my hypothesis from another thread:
i was reading how saw plametto causes PFS since they are both similar drugs in terms of potency and the basics is that they bind to the progesterone receptor and reduce both estrogen and dht. maybe this is what trains the body to work in a way where dht stays low now that the body has been forced to regulate estrogen with progesterone. this is an idea that isnt new and Gbolduev has stated this himself; however, what if the cure is as simple as reducing prog and increasing estrogen AND increasing dht.
ru will lower prog and will increase esrogen since it will upregulate the receptors in the absence of progesterone; however, since ru is also slightly antiandrogen its not guarenteed that DHT will be increased and triggered as the body's main estrogen opposition once again.
i believe that maybe for most PFS cases that if we can lower prog with a SUPER low dose of ru say 10mg, increase estrogen with maybe some licorice AND activate our own dht production through boron, trib, creatine and LCarnatine we can cure this.
this is probably why when taking exogenous DHT + estrogen will alleviate all pfs sides. only issue is they wont stick since its not your body producing these hormones and once the hormones are withdrawn all the benefits go with it.
CDnuts protocol cycles through different herbs that can raise hormones including estrogens so maybe if we can get the right mix of antiprog (which alone will increase estrogen), pro estrogen and pro DHT then maybe that is all that we need to cure this.
saw plametto binds to prog and lowers estrogen and dht so surely doing the exact opposite of this will cure the syndrome.
maybe the reason why RU has yet to fully cure us is because it fixes prog, estrogen and cort but doesnt necessarily always increase DHT since it is a weak anti-androgen. although we have yet to experiment with doses in the range of 10mg so maybe a dose like this can be enough to kill prog whcih will increase estrogen indirectly and allow androgens to rein unopposed.
i know this seems too simple to be the cure, but maybe it is this simple, but there is no ONE drug that can increase estrogen, decrease prog AND upregulate DHT.
all studies on ru486 do show that it increases androgens and adrenal androgens, but those are in bodies that dont have PFS and receptor issues or bodies that fight estrogen with the incorrect hormone. this is a lot to ponder, but im thinking that my next cycle (which would be early 2018) would be 10mg of ru (which IS enough to reduce prog significanly according to literature), some licorice and Boron, Lcarnatine and creatine. heck maybe the licorice wouldnt even be needed since the prog reduction alone will be enough to increase estrogen and estrogen receptor sensativity. i just need some true DHT boosters in there and after speaking with @jacknap i believe Boron and LCarnatine are a must and i personally like creatine for its increase in DHT as well.
what do you guys think of this? seems like a solid theory on paper, but we just need to put it in practice. RU486 works so well cuz it address EVERYTHING except for androgens since it is an antoandrogen. without this trait it could be the finasteride cure that could literally be as easy as popping a pill.
Just out of interest, has anyone tried the DHT + estrogen route. I know its only a temporary fix but surely it would be very useful to know whether it actually works. As surely if people tried this route and it didn't work or do anything, then all the other protocols may need to be rethought? Wouldn't it make sens to try DHT + estrogen? just to make sure we're actually on the right track here.