FINASTERIDE SIGNIFICANTLY UPREGULATES ANDROGEN RECEPTOR in this study ( PROTOCOLS and discussions for PFS)

Helen

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I've had enormous improvement 4 weeks after stopping a protocol of aminos + potassium chloride. I got all the aminos including histidine, cysteine and arginine. I improved the more potassium chloride I added in.

Improvements havent really started to kick in until about 3.5 to 4 weeks post stopping the protocol.


Yes. Potassium lowers ZINC in the cell.( so lowers zinc finger)

May be this is what progesterone is trying to do, keep potassium in the cell so zinc leaves

I think people need to try to load on potassium like me 10000 and more for a week. And see how this effects them
 

Troy

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Yes. Potassium lowers ZINC in the cell.( so lowers zinc finger)
I feel shocking on the protocol and slightly after taking the protocol. Well not shocking, but I don't feel right. But it's definitely worked. I'll probably have to do it again to get fully cured.

I'm not sure whether it was the aminos or whether it was the potassium that had the biggest influence.
 

wuf

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Holy shit, bro. they cut a piece of your penis. you are a crazy italian. )) same as me a crazy russian LOL
You deserve to get cured , bud. Just for this. I think we are very close to getting this thing SHUT down for ever
Yes my friend, I still have the scar (not so much visible), but yes...they made this study at Trieste hospital and that was the place where I met the suffer "CHI" (now he's recovered)...we were like 18 guys getting tested.
I am following you and praying to get up to something.
 

Helen

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We have catalase in the medical books for sure, in reality is way down, its iron on it, plus glutathione peroxidase which selenium is on it. If this part is overworking then glutathione reductase will be as well and thats what drains NADPH. The CAT and GPx should be the main focus and not necessarily the results of their overwork.

You dont have PFS. you have an overexpressed Sods. which do drain your h2o2 enzymes.

You need to slow down, so the oxygen delivery in the cell slows. this way your SOds let down.

Dont mix threads)) bud

Lay down on those borons foods and lets see if this increases your calcium and magnesium levels, so your become less acidic and oxygen stays put out of the cell
And your catalase does not get oxidized that much. catalase is just a pool of NADPH . which helps GPX to do its job.
think about catalase as a NADPH storage. IMO that is all it does.

So if your NO is not working, or arginase gets upregulated, body will use NADPH oxidase to generate ROS. So you have to think about that also.

May be consider some sulfur to lower arginase. or selenium.
 
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Troy

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Yes. Potassium lowers ZINC in the cell.( so lowers zinc finger)

May be this is what progesterone is trying to do, keep potassium in the cell so zinc leaves

I think people need to try to load on potassium like me 10000 and more for a week. And see how this effects them
I recommend building up slowly though. There reached a tipping point for me where it was too much and I clearly didn't have the supporting hormones to back it up. I was getting panic attacks and things felt a bit weird with my heart.
 

Helen

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I recommend building up slowly though. There reached a tipping point for me where it was too much and I clearly didn't have the supporting hormones to back it up. I was getting panic attacks and things felt a bit weird with my heart.


I saw potassium leaving my body big time during this last crash, I felt terrible taking it. but I was loading 10000 of it every 5 hours LOL

IN 2-3 days, My metabolism turned back up
 

Helen

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I recommend building up slowly though. There reached a tipping point for me where it was too much and I clearly didn't have the supporting hormones to back it up. I was getting panic attacks and things felt a bit weird with my heart.


Remember progestereone is there to convserve potassium in the body. So to lower progesterone you need to give the body potassium.
 

Troy

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I saw potassium leaving my body big time during this last crash, I felt terrible taking it. but I was loading 10000 of it every 5 hours LOL

IN 2-3 days, My metabolism turned back up
Did you get panic attacks from it? Or weird heart sensations?
 

Helen

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Did you get panic attacks from it? Or weird heart sensations?

yeah, I got crazy gaba reactions from it. could not breathe , and my heart was going nuts

but I took Bs, and it was better.

Basically cortisol sits there wastes potassium. Without potassium there is no Nitric oxide possible, since nitric oxide is a duaretic.

And progesterone works like crazy to conserve this shit as much as it can.

And as I said, it is a fork. high cortisol which wastes potassium and high progesterone which conserves it))

And all of this is because zinc finger got fucked.
 
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Troy

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yeah, I got crazy gaba reactions from it. could not breathe , and my heart was going nuts

but I took Bs, and it was better.

Basically cortisol sits there wastes potassium. Without potassium there is no Nitric oxide possible, since nitric oxide is a duaretic.

And progesterone works like crazy to conserve this shit as much as it can.

And as I said, it is a fork. high cortisol which wastes potassium and high progesterone which conserves it))

And all of this is because zinc finger got fucked.
So if you take aminos you can lower cortisol and then take potassium and you should get out of the fork.
 

Helen

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So if you take aminos you can lower cortisol and then take potassium and you should get out of the fork.

that was the plan amigo.

This is why It think on electrolytes full protocol, people can recover from everything, ffrom hairloss, from pfs from anything

body is fast enough to regulate itself, but we need to give it stuff in crazy amounts so it just rewrites everything
 

hairsuit

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Yeah, this is what happened to me. Took superdrol, then came off, receptors were downregulated, got flooded with estrogen then DHT (I did no PCT and felt great coming off cycle, zero negative PCT symptoms). I had insane libido and lot of sebum post cycle. About 3-6 months later I noticed my hair thinned out very quick, then started to even get thinner after that. Then I took fin which stopped the hair thinning and I regained a lot of my hair back since it upregulated androgen receptors, but at the cost of very low libido and a million other sides. I also used the topical drug RU58841 during a short time coming off fin which blocks the AR which would even upregulate the AR even MORE, same reason why @jacknap crashed from RU58841 (different from the anti prog drug RU on here). Funny thing is I responded greatly both to fin and RU58841 from a hair perspective, both of them totally reversed and regrew my hair in a short period of time, but at a cost.

So I went from normal receptors then to downregulated receptors then to upregulated receptors and now need to downregulate them again LOL

I do agree that most steroids won't work. Some steroids that could work are potentially anavar, turinabol or superdrol, but the safe more balanced route is zinc finger or ARL/TEI that does it slower...hoping to fine tune the electrolyte (zinc finger) protocol soon when @Helen finalizes it in a new thread/google doc to avoid confusion.
Yeah @TubZy , same here. Used Fin and RU58841 VERY successfully. Had I kept using it, I probably would still be fine today. It was in making the decision to stop Fin that started the cascade. Then when crashed from stopping I stopp RU58841 thinking it could be a culprit as well... things only got worse. Double edged sword.
 

HerrFisch

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Finally some PFS people that are not microdosing Potassium ^^.

Always thought you would need more K for that high Prog but too scared to advise someone to be a guinea pig.
...And be careful. Try to dilute KCl as much as possible.
I think I had some gastritis from too little dilution when using too much. Some stomach problems, and I switched to Coconut water for some time.

@supernature
What are you if you are not PFS and where is your log :D
 

supernature

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You dont have PFS. you have an overexpressed Sods. which do drain your h2o2 enzymes.

You need to slow down, so the oxygen delivery in the cell slows. this way your SOds let down.

Dont mix threads)) bud

Lay down on those borons foods and lets see if this increases your calcium and magnesium levels, so your become less acidic and oxygen stays put out of the cell
And your catalase does not get oxidized that much. catalase is just a pool of NADPH . which helps GPX to do its job.
think about catalase as a NADPH storage. IMO that is all it does.

So if your NO is not working, or arginase gets upregulated, body will use NADPH oxidase to generate ROS. So you have to think about that also.

May be consider some sulfur to lower arginase. or selenium.


...


What are you if you are not PFS and where is your log :D

...
 
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Nina

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I saw potassium leaving my body big time during this last crash, I felt terrible taking it. but I was loading 10000 of it every 5 hours LOL

IN 2-3 days, My metabolism turned back up

How much potassium were you actually taking daily?
 

Minime

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Finally some PFS people that are not microdosing Potassium ^^.

Always thought you would need more K for that high Prog but too scared to advise someone to be a guinea pig.
...And be careful. Try to dilute KCl as much as possible.
I think I had some gastritis from too little dilution when using too much. Some stomach problems, and I switched to Coconut water for some time.

@supernature
What are you if you are not PFS and where is your log :D
Not everyone has high progesterone though. Mine is:
Progesterone: 0.1 ng/dL [< or = 0.2].
Does this mean I should stay away from potassium?
 

Helen

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Boron topically in the shampoo caused hair loss, even more diffusing on top mainly.

Sulfur makes me tired when tried feet soaking in Mg SO4, also B1 makes sweat stinks unusual. If not histidine and arginine, it might be cysteine along with selenium for GPx support. SOD's overexpression, what do you reffer to this ? The snips one has in their SOD genes, they are increased of function i think, not supressed function of the genes.
Overexpressed SODs: this topic havent been discussed so far and Im pretty sure there will be not very few ppl with copies in SODs, eNOS genes for ex, it would be interesting those to be reviewed in more details as well, but from that perspective and not to mix threads, probably in separate thread would fit best.




I dont have one, im not sure if i can hold one either.


overexpressed not in SNPS, as a regulation of metabolism. they work normal for you metabolism

What do SNPS have to do with anything. I presume SNPS are just deficiencies in some minerals. and excess of others.

Overexperssion meaning SODS have to express more in your metabolism. If you have high metabolism SODS will be overexpressed. and will cause too much H2o2 generation

Stop thinking SNPS it is the way nowhere. All SNPS can be changed. I saw it many times on 23 and me. boom and no more mutation LOL

after that I quit looking at them all together
 

noprop

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You are wrong.
i HAVE pfs FROM 12/13 YEARS and after 6 years having it, I got tested and doctors cut me a piece of penis' skin to analise it and they saw that AR is way up up-regulated.
So what @Helen is saying is fucking right.
I do have study about this and about my singular case...they testes something like 18 guys, all had the same issue with upregulated AR.
Very intetesting. Do you have any bloodwork from then?

I am maybe a special case AS well: Had at the beginning of pfs above range testo and free testo. But felt awful, supershrinkage etc. Then 2-3 months later, testo low-middle.
Question: Is this a sign of downregulation of AR as the body tries to get androgenic effects by shooting more testo on receptors? Body then realizes no effect and reduces level to upsentisize AR?
For me the only reasonable answer. THX
 

Helen

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Very intetesting. Do you have any bloodwork from then?

I am maybe a special case AS well: Had at the beginning of pfs above range testo and free testo. But felt awful, supershrinkage etc. Then 2-3 months later, testo low-middle.
Question: Is this a sign of downregulation of AR as the body tries to get androgenic effects by shooting more testo on receptors? Body then realizes no effect and reduces level to upsentisize AR?
For me the only reasonable answer. THX

No it is sign of the LH shut down))

Since when you quit fin your NADPH levels go up and this produces a lot of test , but since the AR is crazy upregulated, then the body just shuts you down
 
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