FINASTERIDE SIGNIFICANTLY UPREGULATES ANDROGEN RECEPTOR in this study ( PROTOCOLS and discussions for PFS)

[noprop]

No it is sign of the LH shut down))

Since when you quit fin your NADPH levels go up and this produces a lot of test , but since the AR is crazy upregulated, then the body just shuts you down

THX. So, now with reduced testo it means NADPH levels decreased?
But my AR are still upsentisized?
So, thats why I feel good on prog?

 

[wuf]

Very intetesting. Do you have any bloodwork from then?
I am maybe a special case AS well: Had at the beginning of pfs above range testo and free testo. But felt awful, supershrinkage etc. Then 2-3 months later, testo low-middle.
Question: Is this a sign of downregulation of AR as the body tries to get androgenic effects by shooting more testo on receptors? Body then realizes no effect and reduces level to upsentisize AR?
For me the only reasonable answer. THX

Sure I have hormonal blood tests since I have PFS. I also have had very high testo, since I crashed with DHEA and I had an under range testo.
We are not special cases, this is PFS-- it is well documented that in PFS suffer, the AR IS UPREGULATED.

 

[Troy]

Sure I have hormonal blood tests since I have PFS. I also have had very high testo, since I crashed with DHEA and I had an under range testo.
We are not special cases, this is PFS-- it is well documented that in PFS suffer, the AR IS UPREGULATED.

You tried adding the potassium to your protein shakes yet?

 

[wuf]

You tried adding the potassium to your protein shakes yet?

I did try it here and there but I am not sure in what I am doing so, I am suspicious and I don't want to create more damages.
At the moment I am in a condition where I am functional and I am feeling here and there everything coming back like old times, so not sure if it is the case to touch something that I even don't know if it will harm or help my recover.

 

[Troy]

I did try it here and there but I am not sure in what I am doing so, I am suspicious and I don't want to create more damages.
At the moment I am in a condition where I am functional and I am feeling here and there everything coming back like old times, so not sure if it is the case to touch something that I even don't know if it will harm or help my recover.

Fair enough. So do you feel like you have improved?

 

[Helen]

How much potassium were you actually taking daily?

May be 30k LOL

 

[wuf]

Fair enough. So do you feel like you have improved?

Yes definitely..
I started to improve since I added protein shake (mass gainer) to my diet, having a mediterranean diet and trying supplementing here and there with electrolities, chloride potassium etc... but not so much since I really don't know what I am doing (I still don't have an hair test).
By the way it is still depending from one day to the other, for sure I am not dieing anymore and I can feel improvements in all area...still not at the place where I want to be.

 

[Troy]

yeah, I got crazy gaba reactions from it. could not breathe , and my heart was going nuts

but I took Bs, and it was better.

Basically cortisol sits there wastes potassium. Without potassium there is no Nitric oxide possible, since nitric oxide is a duaretic.

And progesterone works like crazy to conserve this shit as much as it can.

And as I said, it is a fork. high cortisol which wastes potassium and high progesterone which conserves it))

And all of this is because zinc finger got fucked.

Was just thinking after I said aminos to lower cortisol and potassium for the progesterone.

If we are in a fork where both are high, shouldn’t we just try to lower the cortisol and keep the progesterone high. So take the aminos but leave out the potassium?

 

[noprop]

Sure I have hormonal blood tests since I have PFS. I also have had very high testo, since I crashed with DHEA and I had an under range testo.
We are not special cases, this is PFS-- it is well documented that in PFS suffer, the AR IS UPREGULATED.

So I need to downregulate. Make them less sensitive?
Ru or Ella in this case?

 

[Admiral]

Don’t get it. Most PFS member have low hormonal output, at least from my experience here and at solvepfs/propeciahelp. Only estrogen and TSH are often elevated.

 

[noprop]

I think my AR are downregulated due to uprising levels DHT. They were upsentisized on fin, no question. But no more. Thats why putting testo does not do a lot. If they were still upsentisized like one guy experienced on ph you would be hypersexual. Thats it.
And we do have neurosteroidal imbalances. How to treat that? Yeah.

 

[Helen]

Was just thinking after I said aminos to lower cortisol and potassium for the progesterone.

If we are in a fork where both are high, shouldn’t we just try to lower the cortisol and keep the progesterone high. So take the aminos but leave out the potassium?

I think my AR are downregulated due to uprising levels DHT. They were upsentisized on fin, no question. But no more. Thats why putting testo does not do a lot. If they were still upsentisized like one guy experienced on ph you would be hypersexual. Thats it.
And we do have neurosteroidal imbalances. How to treat that? Yeah.

LOL did you not you read that 18 people were tested and all their receptors were upregulated. that is years off of finasteride.


You are not going to hypersexual with upregulated AR< you will have low estrogen action. and will feel like you are taking aromatase inhibitor. Try to be supersexual on that


Plus we do have 2 cases here any way.

Why are you asking all these questions if the first post answers all of them.

 

[IHateFin]

they stay upregulated all the time. the androgen receptor simply work on zinc finger and arginine.

there is no upregultaed or downregulated. If zinc finger is upregulated you have low estrogen stopping it from working. If you have it downregulated you have prolactin shutting you down

So drugs will never CURE PFS< you will be flying from one side to another

Exactly if the receptors are upregulated , HTPA inhibits itself and you run on low estrogen. take AI and tell me how you will be hyperandrogenic



People seem to miss what I am saying.


You need 3 systems working properly for AR and androgen receptor to work properly


IT is cysteine system( glutathione) it is histidine system ( histamine ) and arginine system( nitric oxide)


This is because androgens release nitric oxide. and so when there is no nitric oxide, body will stop androgen production

Same as if there is no glutathione body will shut you down also.

Now tell me how taking drugs will fix these systems.

Even before fin or SRRIs you guys had problems, with these systems

And your crazy libido had nothing to do with normal libido. It was just histamine induced itch. It was not normal androgen receptor functioning


SO taking drugs like anavar, will put you from low histamine state to high . That is all. and you will get crazy hairloss. stupid obsessive behaviour about sex etc

this is not Normal androgen functioning. This is as sick as being in PFS state


This is why I am saying balancing these systems can be achieved by some drug))

It is all about minerals balance inside of your body.

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .


Since with drugs youdont fix minerals, you just fly from one side to another. With major problems on all sides

Like you think Tubzy wll live with a hairloss LOL


NO he wont. If he uses superdrol or anvar., fixes PFS, get histamine imbalance and what's there. There will be many histamine problems. And then he will start fixing his hair LOL which he will lose in weeks

And go right back to PFS again.

wait so if receptors are upregulated then wouldnt mct oil or capriyic acid hurt us then?

 

[Helen]

wait so if receptors are upregulated then wouldnt mct oil or capriyic acid hurt us then?

you dont know how capric acid works. I think it works thru estrogen receptor


I am trying it out.


plus this upregultated downregulated - we have 2 cases here obivously

 

[IHateFin]

they stay upregulated all the time. the androgen receptor simply work on zinc finger and arginine.

there is no upregultaed or downregulated. If zinc finger is upregulated you have low estrogen stopping it from working. If you have it downregulated you have prolactin shutting you down

So drugs will never CURE PFS< you will be flying from one side to another

Exactly if the receptors are upregulated , HTPA inhibits itself and you run on low estrogen. take AI and tell me how you will be hyperandrogenic



People seem to miss what I am saying.


You need 3 systems working properly for AR and androgen receptor to work properly


IT is cysteine system( glutathione) it is histidine system ( histamine ) and arginine system( nitric oxide)


This is because androgens release nitric oxide. and so when there is no nitric oxide, body will stop androgen production

Same as if there is no glutathione body will shut you down also.

Now tell me how taking drugs will fix these systems.

Even before fin or SRRIs you guys had problems, with these systems

And your crazy libido had nothing to do with normal libido. It was just histamine induced itch. It was not normal androgen receptor functioning


SO taking drugs like anavar, will put you from low histamine state to high . That is all. and you will get crazy hairloss. stupid obsessive behaviour about sex etc

this is not Normal androgen functioning. This is as sick as being in PFS state


This is why I am saying balancing these systems can be achieved by some drug))

It is all about minerals balance inside of your body.

This is why long term. no matter who is doing what on this site, like hormones, like this and that. you all will come to mineral balancing


And something like electrolytes protocol or TEI or ARL will fix all these system downthe line .


Since with drugs youdont fix minerals, you just fly from one side to another. With major problems on all sides

Like you think Tubzy wll live with a hairloss LOL


NO he wont. If he uses superdrol or anvar., fixes PFS, get histamine imbalance and what's there. There will be many histamine problems. And then he will start fixing his hair LOL which he will lose in weeks

And go right back to PFS again.

What you're saying makes sense BUT I personally would rather be sick and hypersexual and happy than sick and have little sex drive n be sad (PFS) ... I feel like the hypersexual and happy was me pre finasteride since I obviously was sick enough for my hair to literally be melting off my head lol

 

[IHateFin]

you dont know how capric acid works. I think it works thru estrogen receptor


I am trying it out.


plus this upregultated downregulated - we have 2 cases here obivously

I'm trying it out today as the first day too!
So if lowering dht/ 5AR makes me feel better than would I be the downregulated case of up regulated? Shit is starting to get confusing haha

 

[noprop]

LOL did you not you read that 18 people were tested and all their receptors were upregulated. that is years off of finasteride.


You are not going to hypersexual with upregulated AR< you will have low estrogen action. and will feel like you are taking aromatase inhibitor. Try to be supersexual on that


Plus we do have 2 cases here any way.

Why are you asking all these questions if the first post answers all of them.

Go on ph and look what it is written about that guy. Some people have androgen resistance due to what?
Those two cases are a guess. Nothing that is underlied with any study, right?
So guesses are okay AS long AS they are communicated AS such. Best

 

[Ingeno]

LOL did you not you read that 18 people were tested and all their receptors were upregulated. that is years off of finasteride.


You are not going to hypersexual with upregulated AR< you will have low estrogen action. and will feel like you are taking aromatase inhibitor. Try to be supersexual on that


Plus we do have 2 cases here any way.

Why are you asking all these questions if the first post answers all of them.

This is exactly what I got after I quit finasteride, every supplement that lowered my estrogen I felt bad on it, depression, dry eyes/skin low motivation, you name it. @Helen what about Zinc? I felt great on zinc before finasteride, now It seems I can't tolerate zinc anymore. Also aromatase inhibitor?

 

[Helen]

I'm trying it out today as the first day too!
So if lowering dht/ 5AR makes me feel better than would I be the downregulated case of up regulated? Shit is starting to get confusing haha

it is confusing , since the receptor is combined from 3 systems, so you cant really say upregulated or downregulated IMO

 

[BeLikeWater]

I feel like after the crash androgen receptors probably don't stay up regulated... if that were the case we would be stuck hyper androgenic and we all seem hypo androgenic... I think at a point the receptors are sensitive then the rush of dht down regulates them and at the same time the spike in dht causes a negative feedback loop and the HPTA inhibits its self. Once it slowly comes back receptors are in a lot of cases still fried

Have you look at teh last emails of postfinasteride syndrome? They are talking that they think our issues come from upregulated androgen receptors, it has been studied that if a receptor is completly upregulated it stops making it works