Guggul (guggulsterone) - FXR receptor antagonist

[tanedout]

Does anyone have any experience of using this stuff?

It's an FXR receptor antagonist and it looks like it's included in some supplements which are intended to improve bile flow;

Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump

20 Surprising Health Benefits of Guggul + Side Effects - SelfHacked

GUGGULSTERONES
These are the apparent bioactive compounds of guggul, an herbal extract from resin of the Commiphora mukul tree. Guggul is widely used in Ayurveda for its effect on blood lipids, and research suggests that guggulsterones may antagonize two nuclear hormone receptors involved in cholesterol metabolism.

For example, it has been demonstrated that guggulsterone is a selective modulator of a particular bile acid receptor called a “farnesoid X receptor” (FXR). By acting as an antagonist to FXR, the guggulsterone can regulate the bile salt export pump.

In other words, guggulsterone can modify the rate and amount of bile salts transported out of the liver (18, 19, 20).

Bile Flow Support

@Helen have you heard of this herb, do you think this could potentially be useful?

 

[shivgeorge]

I have the extract of Guggul from Himalaya. Initially I did not like it at all and put it at the back of my shelf. But recently I tried it again and it seemed to improve concentration. I must warn you, it is a very potent thing, so I usually take a quarter to a half of a capsule. When I initially tried a full capsule, it seemed to make the sexual problems worse, which was the reason I had decided to stop using it. Smaller amounts have no such affect.

 

[tanedout]

I have the extract of Guggul from Himalaya. Initially I did not like it at all and put it at the back of my shelf. But recently I tried it again and it seemed to improve concentration. I must warn you, it is a very potent thing, so I usually take a quarter to a half of a capsule. When I initially tried a full capsule, it seemed to make the sexual problems worse, which was the reason I had decided to stop using it. Smaller amounts have no such affect.

Did you try cycling it at all, like maybe a few days on, a few days off? So smaller amounts improve mental clarity?

 

[shivgeorge]

Yes. Coincidentally, I just tried it yesterday after having had it previously two or so months ago. No, I did not plan to cycle it because the first time I had it, I came to know how potent it was. I will probably try another small amount today or in a few days. I usually only cycle things (take them on for a few days consecutively) if they suit me. Things that don't - I just consume a small amount and then let it rest for a week or two.

Also, to clarify, I don't have the highest quality. I have the off-white stuff. The brown stuff with higher amounts of Gugglesterone is sold by Himalaya in the US, not in India.

 

[shivgeorge]

Can confirm my experience was not positive even with small amounts.

 

[tanedout]

Can confirm my experience was not positive even with small amounts.

Thanks for letting us know! So you didn't experience any 'rebound' a few days after stopping, or anything like that?

 

[Helen]

Thanks for letting us know! So you didn't experience any 'rebound' a few days after stopping, or anything like that?

isnt this one similar to beta sitosterol. In other worlds, doesn't this act like saw palmetto?

 

[shivgeorge]

Thanks for letting us know! So you didn't experience any 'rebound' a few days after stopping, or anything like that?

I just felt more lethargic. The negative effect disappeared on the second day.