- Messages
- 5,415
Recently we talked about high and low DHT cases in PFS. These cases are totally different and react to absolutely different things. Here I will try to propose the explanation why and what is happening, based on everything that we know so far. ( the reactions of people to supplements, the reaction of people to anavar, the offical studies and CURES of postfinasteride syndrome which were posted in offical studies)
IN my opinion
1) low DHT people ( with inhibited axis) have overexpressed ARs in DHT sensitive tissues. This stops their 5AR from working, which impairs allopregnenolone levels ( they have anxiety)
These people react badly to DHT supplements and feel much better on anavar.( which blocks AR receptors) ,
2) high DHT people, have GABA A receptor problem , which stops 3 alpha hsd from working, which raises their progesterone, which blocks their AR receptors, and this then raises DHT levels. these people feel much better on ella which kills their progesterone and opens up androgen receptor.
Case 1. description.
feel terrible on androgens and crash on them even though their testosterone levels could be low in some cases.
These people need to go on testosterone low dose and keep at it, until they wont crash anymore. Testosterone does not create any low testosterone states.
Testosterone simply binds NADPH molecule and creates DHT. Testosterone plus NADPH= DHT. you cant handle DHT, you crash on it. so you need to take tiny amounts of it, to get your body used to DHT again. or take tiny amounts of testosterone which will keep pushing creation of DHT also in tiny amounts and slowly get your body to be accustomed to higher DHT levels
This is what tribulus does. and people keep crashing on it. but if you keep at it. it will restore you and as it restored many people on propeciahelp
This is what Cdnuts protocol is. Basicallly in this case you need to increase your 5AR and keep it high , so the body gets acclimated to higher DHT levels and downregulates the receptors.
when receptors get downregulated, the body will want more 5AR action, and this will increase allopregnenolone, all by itself and anxiety will stop.
Case 2 description
the main problem is GABA A receptor. These people should feel better on dht. since progesterone is blocking their Androgen receptor.
As soon as these people downregulate GABA A receptor , they 3 alpha hsd will open up and it will start converting progesterone further into allopregnenolone and DHT into 3 adiol. Progesterone will fall, and androgen receptor blockage will stop.
These people feel better on ella. the feel better on ginko. which is gaba receptor antagonist.( but IMO those are just stilts.)) I think these might be the people who responded to GHB and got cured.
So gaba agonist should make these people feel worse. but may be cure them over time.
So these things above if tried should make people feel worse when tried and work on snapbacks.( IMO how cure should be)
Now lets see stilts which should make these people better
1) these people feel better on anavar. these people feel better on gaba agonists. or gaba receptor agonists. they would feel better if they increase density of gaba a receptors.
2) these people feel better on DHT, and they feel better on gaba antagonists( ginko) . these people feel better if they increase density of their AR receptors
it is important to understand that these are stilts. you are basically not fixing anything. for instance in case of number 2. your progesterone is blocking your AR. so if you increase the density of the ARs, you will feel better ( but the goal is to fix gaba) and this will lower progesterone and free up androgen receptor.
here is the offical study https://www.omicsonline.org/open-ac...eview-of-the-literature-2472-1212-1000170.pdf
where they cured people from PFS with low levels of DHT n blood with test ( dht ) and aromatase inhibitors( which makes sense, since you basically do the opposite of what finasteride did to them)
Same therapy DID NOT work for high DHT people which is understanable why if this theory described above is correct.
Lets discuss this, I think this is pretty much straightforward.
This can be done with minerals and vitamins, also.
Low dose finasteride regimen( which worked for some people) creates spikes in NADPH after it unbinds it. in 4-7 hours. Basically like taking low doses of DHT. It creates DHT spikes.
So it would have been a proper way of getting off of it. Not really decreasing the dosages daily taken, but decreasing the number of days which you take it on.
This would keep that supersexual period last longer and it will give the body ability to get adjusted to it.
I mentioned before that fin binds NADPH. so if we keep spiking NADPH we can downregulate what fin was doing.
NADPH oxidase is the enzyme which breaks down NADPH, and this enzyme can be inhibited by hydrogen peroxide as an example.
NADPH oxidase is the enzyme which makes hydrogen perioxide for the thyroid gland. that is why NADPH oxidase effects your IMMUNE system ( since it is your IMMUNE SYSTM ) and also it effects thyroid since it makes thyroid hormones.. may be some people have forms of hashimoto
Lets discuss this. I could mix these cases with other
another possibility is that gaba problem causes LH inhibition in one cases. So we need to take into account, that cases could be inverted.
IN my opinion
1) low DHT people ( with inhibited axis) have overexpressed ARs in DHT sensitive tissues. This stops their 5AR from working, which impairs allopregnenolone levels ( they have anxiety)
These people react badly to DHT supplements and feel much better on anavar.( which blocks AR receptors) ,
2) high DHT people, have GABA A receptor problem , which stops 3 alpha hsd from working, which raises their progesterone, which blocks their AR receptors, and this then raises DHT levels. these people feel much better on ella which kills their progesterone and opens up androgen receptor.
Case 1. description.
feel terrible on androgens and crash on them even though their testosterone levels could be low in some cases.
These people need to go on testosterone low dose and keep at it, until they wont crash anymore. Testosterone does not create any low testosterone states.
Testosterone simply binds NADPH molecule and creates DHT. Testosterone plus NADPH= DHT. you cant handle DHT, you crash on it. so you need to take tiny amounts of it, to get your body used to DHT again. or take tiny amounts of testosterone which will keep pushing creation of DHT also in tiny amounts and slowly get your body to be accustomed to higher DHT levels
This is what tribulus does. and people keep crashing on it. but if you keep at it. it will restore you and as it restored many people on propeciahelp
This is what Cdnuts protocol is. Basicallly in this case you need to increase your 5AR and keep it high , so the body gets acclimated to higher DHT levels and downregulates the receptors.
when receptors get downregulated, the body will want more 5AR action, and this will increase allopregnenolone, all by itself and anxiety will stop.
Case 2 description
the main problem is GABA A receptor. These people should feel better on dht. since progesterone is blocking their Androgen receptor.
As soon as these people downregulate GABA A receptor , they 3 alpha hsd will open up and it will start converting progesterone further into allopregnenolone and DHT into 3 adiol. Progesterone will fall, and androgen receptor blockage will stop.
These people feel better on ella. the feel better on ginko. which is gaba receptor antagonist.( but IMO those are just stilts.)) I think these might be the people who responded to GHB and got cured.
So gaba agonist should make these people feel worse. but may be cure them over time.
So these things above if tried should make people feel worse when tried and work on snapbacks.( IMO how cure should be)
Now lets see stilts which should make these people better
1) these people feel better on anavar. these people feel better on gaba agonists. or gaba receptor agonists. they would feel better if they increase density of gaba a receptors.
2) these people feel better on DHT, and they feel better on gaba antagonists( ginko) . these people feel better if they increase density of their AR receptors
it is important to understand that these are stilts. you are basically not fixing anything. for instance in case of number 2. your progesterone is blocking your AR. so if you increase the density of the ARs, you will feel better ( but the goal is to fix gaba) and this will lower progesterone and free up androgen receptor.
here is the offical study https://www.omicsonline.org/open-ac...eview-of-the-literature-2472-1212-1000170.pdf
where they cured people from PFS with low levels of DHT n blood with test ( dht ) and aromatase inhibitors( which makes sense, since you basically do the opposite of what finasteride did to them)
Same therapy DID NOT work for high DHT people which is understanable why if this theory described above is correct.
Lets discuss this, I think this is pretty much straightforward.
This can be done with minerals and vitamins, also.
Low dose finasteride regimen( which worked for some people) creates spikes in NADPH after it unbinds it. in 4-7 hours. Basically like taking low doses of DHT. It creates DHT spikes.
So it would have been a proper way of getting off of it. Not really decreasing the dosages daily taken, but decreasing the number of days which you take it on.
This would keep that supersexual period last longer and it will give the body ability to get adjusted to it.
I mentioned before that fin binds NADPH. so if we keep spiking NADPH we can downregulate what fin was doing.
NADPH oxidase is the enzyme which breaks down NADPH, and this enzyme can be inhibited by hydrogen peroxide as an example.
NADPH oxidase is the enzyme which makes hydrogen perioxide for the thyroid gland. that is why NADPH oxidase effects your IMMUNE system ( since it is your IMMUNE SYSTM ) and also it effects thyroid since it makes thyroid hormones.. may be some people have forms of hashimoto
Lets discuss this. I could mix these cases with other
another possibility is that gaba problem causes LH inhibition in one cases. So we need to take into account, that cases could be inverted.
Last edited:
