Usually people are intolerant to salicylates since there is no bioavailable copper. histidine makes copper available, since copper becomes available when there is histamine production present. IF there is no histidine, copper will become unavailable, since copper breaks down histamine and without histidine , there is no histamine. If copper is not available zinc and b6 are suppressed also since they convert histidine into histamine. When b6 is suppressed( or stays in its inactive form) since there is no copper available , your cant convert glutamate into gaba, thus you get stuck with high glutamate. this causes anxiety. and low stress tolerance.
this is done on purpose since glutamate into gaba conversion makes CO2. and without histidine body cant afford extra copper or Co2 , since histidine makes carbon anhydrase enzyme stay active and utilize Co2. Thus body stays in high glutamate state to substitute for low methylation , since folic acid is not converted into its active form in histidine deficiency, since active folate converts histidine into glutamic acid.
This is why it worked for that woman in the thread that I posted to you. when you feed copper and histidine and selenium. It lowers glutamate and increases conversion of folate into active folate and this starts methylation. When methylation starts you get improvements with learning socializing etc.
I hope this makes sense
