How does PFS cause Premature Ejaculation

RebelWithACause

Well-Known Member
Messages
2,557
Both are shit. PE is bad if you want to build a relationship with a girl since she will start craving other dick. DE is shit because the girl will think she is not hot enough. I prefer DE over PE.

PE is a pain in the ass.

I read a thread on estrogen on a forum and guy said high estrogen made him have DE. He was on TRT and when he would get too high estrogen he could not orgasm or very hard time.

I also remember on a pick up forums was following, guys took high amounts of zinc for a while and a guy posted that he was getting PE from it. They were taking 100-150mg. I think that amount can lower your estrogen quite a bit.

PE could be caused by insensitive estrogen or something with estrogen in general.
 

MNK99

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Messages
5,356
Either can be temporarily rectified by lying.
Or negating the partner's pseudo-sufficient assumptions. Possibly bath mate usage as well. AND TIME (way more time than any of us want, sometimes).
Weaken their argument, and if the partner is not necessary for success, then allow oneself to separate entirely. After closing the deal at least.
If you are speaking about LTR's then... most of the above will not work.
 
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Walker

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Messages
509
It's an estrogen thing. Or it was for me..... I was the opposite prior PFS, I had DE. Literally having thirty, fourty minute....sometimes to an hour sessions. My now wife and others before her literally would bitch it took so long. I didn't enjoy it either, and honestly I think mine was probably due to a light porn addiction I didn't think was that odd......society, lol. Once PFS hit, it switched to the other extreme, PE.

For the PFS induced PE, I narrowed it down to estrogen, and low estrogen at that causing it. It would get substantially worse on R Andro. I added in 4 Andro, during my recovery - and it was like immediately cured. It came back again for a week or so after that R/4 Andro run, and then went away for good. Something in the estrogen receptor/system is what causes it, in my experience. Your mileage may vary, of course.

EDIT: clarity
 
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brix

Well-Known Member
Messages
593
It's an estrogen thing. Or it was for me..... I was the opposite prior PFS, I had DE. Literally having thirty, fourty minute....sometimes to an hour sessions. My now wife and others before her literally would bitch it took so long. I didn't enjoy it either, and honestly I think mine was probably due to a light porn addiction I didn't think was that odd......society, lol.

I narrowed it down to estrogen, and low estrogen at that causing it. It would get substantially worse on R Andro. I added in 4 Andro, during my recovery - and it was like immediately cured. It came back again for a week or so after that R/4 Andro run, and then went away for good. Something in the estrogen receptor/system is what causes it, in my experience. Your mileage may vary, of course.

So your DE went away after raising estro through 4 Andro?
 

Walker

Well-Known Member
Messages
509
So your DE went away after raising estro through 4 Andro?

Sorry, I didn’t clarify. The PE induced by PFS was resolved in this manner. Now, currently I’m back leaning more towards DE but not as bad as I was prior to PFS.

Just edited my original post for clarity.
 

hairsuit

Well-Known Member
Messages
460
It's an estrogen thing. Or it was for me..... I was the opposite prior PFS, I had DE. Literally having thirty, fourty minute....sometimes to an hour sessions. My now wife and others before her literally would bitch it took so long. I didn't enjoy it either, and honestly I think mine was probably due to a light porn addiction I didn't think was that odd......society, lol. Once PFS hit, it switched to the other extreme, PE.

For the PFS induced PE, I narrowed it down to estrogen, and low estrogen at that causing it. It would get substantially worse on R Andro. I added in 4 Andro, during my recovery - and it was like immediately cured. It came back again for a week or so after that R/4 Andro run, and then went away for good. Something in the estrogen receptor/system is what causes it, in my experience. Your mileage may vary, of course.

EDIT: clarity
Great info......
 

Snow1

Well-Known Member
Messages
180
It's an estrogen thing. Or it was for me..... I was the opposite prior PFS, I had DE. Literally having thirty, fourty minute....sometimes to an hour sessions. My now wife and others before her literally would bitch it took so long. I didn't enjoy it either, and honestly I think mine was probably due to a light porn addiction I didn't think was that odd......society, lol. Once PFS hit, it switched to the other extreme, PE.

For the PFS induced PE, I narrowed it down to estrogen, and low estrogen at that causing it. It would get substantially worse on R Andro. I added in 4 Andro, during my recovery - and it was like immediately cured. It came back again for a week or so after that R/4 Andro run, and then went away for good. Something in the estrogen receptor/system is what causes it, in my experience. Your mileage may vary, of course.

EDIT: clarity
Did you ever take minoxidil walker? My PE came from taking Minoxidil
 

joekool

Moderator
Messages
551
I want to touch on what @Walker is describing and make the point of receptors... though I'm sure I'll get the normal reply from someone on here.

In males, estrogen sensitizes the Androgen Receptor and allows for the uptake of DHT. @Walker used 4-Andro but oral DHEA converts to estrogen in males at a high rate too. I'd be interested in hearing of someone's results with 10 to 20 mg of DHEA about an hour before intercourse, relating to libido and orgasm, with or without R-Andro for it's DHT.

Additionally, as PFS sufferers go, there's a neurological component of the D2 / Dopamine receptor that's responsible for male orgasm & ejaculate. Mucuna-Pruriens has been shown to help this with it's work on dopamine:

Mucuna Pruriens

All this is safe to experiment with, even the dhea at dosages up to 50mgs if you felt something at 10 to 20...

Serotonin and GABA are also relevant too but I believe mucuna would be my first supplement to try as it's very safe and could improve other symptoms as dopamine is for overall well being. There are other supplements too, some to even block dopamine to up regulate the D2 receptor but I tend to feel that cycle could be risky for those in a depressed state so I won't list it.
 

Walker

Well-Known Member
Messages
509
Did you ever take minoxidil walker? My PE came from taking Minoxidil

Negative, I only had Saw Palmetto induced-PFS.
 

brix

Well-Known Member
Messages
593
Studies have recently showed that men with PE have low TSH, prolactin, and LH, with the latter being the most important.

My tsh and prolactin are high so maybe it is my LH that is low.
 

ballheadbuddha

Well-Known Member
Messages
86
Studies have recently showed that men with PE have low TSH, prolactin, and LH, with the latter being the most important.

My tsh and prolactin are high so maybe it is my LH that is low.

I don't belive it's that pontual.. might be from low/high serotonin, high histamine, low GABA @Walker saying about its relation with Estrogen, and now LH..
 

Helen

Well-Known Member
Staff member
Messages
5,415
I want to touch on what @Walker is describing and make the point of receptors... though I'm sure I'll get the normal reply from someone on here.

In males, estrogen sensitizes the Androgen Receptor and allows for the uptake of DHT. @Walker used 4-Andro but oral DHEA converts to estrogen in males at a high rate too. I'd be interested in hearing of someone's results with 10 to 20 mg of DHEA about an hour before intercourse, relating to libido and orgasm, with or without R-Andro for it's DHT.

Additionally, as PFS sufferers go, there's a neurological component of the D2 / Dopamine receptor that's responsible for male orgasm & ejaculate. Mucuna-Pruriens has been shown to help this with it's work on dopamine:

Mucuna Pruriens

All this is safe to experiment with, even the dhea at dosages up to 50mgs if you felt something at 10 to 20...

Serotonin and GABA are also relevant too but I believe mucuna would be my first supplement to try as it's very safe and could improve other symptoms as dopamine is for overall well being. There are other supplements too, some to even block dopamine to up regulate the D2 receptor but I tend to feel that cycle could be risky for those in a depressed state so I won't list it.



Estrogen increases copper in the cell, which increases methylation, so estrogen should lower number of ARs. by increasing signaling and it does.

Estrogen down-regulation of androgen receptors in cultured human mammary cancer cells (MCF-7). - PubMed - NCBI



DHEA binds estrogen receptor directly)) since it is an estrogen, it does not even have to convert anywhere,

and DHEA blocks androgen receptor.

DHEA has been found to directly act on several neurotransmitter receptors, including acting as a positive allosteric modulator of the NMDA receptor, as a negative allosteric modulator of the GABAA receptor, and as an agonist of the σ1 receptor.[28][25]


in some people DHEA is very high in PFS, which is blocking their androgen receptor. since DHEA itself is ANTIANDROGEN.



in PFS , DHT is very low in CSF, JOEKOOL. since its UPTAKE IS HUGE into the receptors)) the SIGNALING IS NOT WORKING>

thus the body created TONS OF RECEPTORS, and that is why you see LOW DHT in CSF. since it is all uptaken into the receptors and BOUND
 
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Blugrass

Well-Known Member
Messages
176
Estrogen increases copper in the cell, which increases methylation, so estrogen should lower number of ARs. by increasing signaling and it does.

Estrogen down-regulation of androgen receptors in cultured human mammary cancer cells (MCF-7). - PubMed - NCBI



DHEA binds estrogen receptor directly)) since it is an estrogen, it does not even have to convert anywhere,

and DHEA blocks androgen receptor.

DHEA has been found to directly act on several neurotransmitter receptors, including acting as a positive allosteric modulator of the NMDA receptor, as a negative allosteric modulator of the GABAA receptor, and as an agonist of the σ1 receptor.[28][25]


in some people DHEA is very high in PFS, which is blocking their androgen receptor. since DHEA itself is ANTIANDROGEN.



in PFS , DHT is very low in CSF, JOEKOOL. since its UPTAKE IS HUGE into the receptors)) the SIGNALING IS NOT WORKING>

thus the body created TONS OF RECEPTORS, and that is why you see LOW DHT in CSF. since it is all uptaken into the receptors and BOUND

My DHEA is always high above the range

Copper and ceruluplasmin are always low