I’m highly suspecting from NMDA imbalance

[Enricks]

I has been quite different from the people on pssd community. My problems are more like a neurodegeneration rather than a sexual dysfunction.

List of the symptoms I have been dealing with:

- EXTREME Cognitive impairment (all the type of memories, memory retention, verbal processing, imagination, etc.)

- Fine motor skill dysfunctions. ( I was able to type with 10 fingers, and I was really fast. Now, I’m BARELY HOLDING A PEN. I forgot to how to move of my body. I’m retyping literally every word several times.) Because of it, I had to stop talking. I can't pronounce words correctly most of the time.)

- My muscles are trembling. This one the last symptom I have observed so far because it’s the sign of a really serious problem. They are constantly trembling(I feel in my inside) and sometimes I’m getting random shocks (myoclonic jerks, I guess).

- No emotion at all. Even the negative ones. (Again, I used to be very emotional person. And I was also a victim of serious anxiety disorder.)

- Zero libido

- Shivering. I’m much more sensitive to cold.

- General Fatigue

- Visual problems (I checked my eyes. I’m sure That’s absolutely because of the pssd.)

- Loss of taste and smell perception

- Muscle weakness

- Estrogen dominance symptoms ( fat on the belly, gynocomestia(unilateral), etc.)


Notes.
——————————————————

- I have been in this since a year ago.
- The med was Prozac.
- Everything started on the 3rd day with the symptom which is hypersomnia
- I totally used it for 20 days
- I didn’t use any med after that day or also I hadn’t use any med before that.
- I was completely functional and normal before the med
- I’m 17 and at 1.75 tall, 61 kg weight.
- I was using my English more correctly before that, But it made me really stupid that I can’t even use my native language proprietaly. So sorry ;(
- Caffeine and masturbation accelerating progress of the disease.
- Cyproheptadine didn’t do anything. Even on doses like 4 mg (I got serious hypoglycemia from that)
- All of my problems progressively worsening since that day. No windows at all. Muscle jerks and trembles are happening so frequent this week.
- That’s the result paper of my hormone test:






- Cortisol is on the lower range.....



What I’m suspecting
———————————————

There is a problem with the NMDA or with glutamate. Nearly all of my symptoms are checks with the “Low NMDA signalling”. But also I feel like it’s a excitotoxicity. Look at the huntington disease...

Also İ had seen that low nmda can induce excitotoxicty by the disinhibiton of GABA neurons. So I’m really desperate this point. I don’t want to harm myself further but I will probably not even able to talk a few months later.

I need a way to hard reset my NMDA system...

 

[Helen]

did you try to cycle l theanine


this can increase gaba , downregulate its receptor over time, and upregulate NDMA

 

[talkingant]

I've had good results with Profrontal (Sarcosine + NAC) for anhedonia. This combo supposedly enhances NMDA signaling. I dont have anywhere near as bad of symptoms as you but if you suspect NDMA then it's worth a shot, IMO. It took a little over a month for me to notice improvements.

 

[Area-1255]

I’m guessing the OP read my Low NMDA Symptoms article...try E-Pharm Test Force II (DAA + Sarcosine), and one teaspoon of Diyesta
CEYLON Cinnamon per day. Cinnamon is both neuroprotective + enhances/extends NMDA-signaling!

 

[Maxin]

I has been quite different from the people on pssd community. My problems are more like a neurodegeneration rather than a sexual dysfunction.

List of the symptoms I have been dealing with:

- EXTREME Cognitive impairment (all the type of memories, memory retention, verbal processing, imagination, etc.)

- Fine motor skill dysfunctions. ( I was able to type with 10 fingers, and I was really fast. Now, I’m BARELY HOLDING A PEN. I forgot to how to move of my body. I’m retyping literally every word several times.) Because of it, I had to stop talking. I can't pronounce words correctly most of the time.)

- My muscles are trembling. This one the last symptom I have observed so far because it’s the sign of a really serious problem. They are constantly trembling(I feel in my inside) and sometimes I’m getting random shocks (myoclonic jerks, I guess).

- No emotion at all. Even the negative ones. (Again, I used to be very emotional person. And I was also a victim of serious anxiety disorder.)

- Zero libido

- Shivering. I’m much more sensitive to cold.

- General Fatigue

- Visual problems (I checked my eyes. I’m sure That’s absolutely because of the pssd.)

- Loss of taste and smell perception

- Muscle weakness

- Estrogen dominance symptoms ( fat on the belly, gynocomestia(unilateral), etc.)


Notes.
——————————————————

- I have been in this since a year ago.
- The med was Prozac.
- Everything started on the 3rd day with the symptom which is hypersomnia
- I totally used it for 20 days
- I didn’t use any med after that day or also I hadn’t use any med before that.
- I was completely functional and normal before the med
- I’m 17 and at 1.75 tall, 61 kg weight.
- I was using my English more correctly before that, But it made me really stupid that I can’t even use my native language proprietaly. So sorry ;(
- Caffeine and masturbation accelerating progress of the disease.
- Cyproheptadine didn’t do anything. Even on doses like 4 mg (I got serious hypoglycemia from that)
- All of my problems progressively worsening since that day. No windows at all. Muscle jerks and trembles are happening so frequent this week.
- That’s the result paper of my hormone test:

View attachment 1392
View attachment 1393
View attachment 1394


- Cortisol is on the lower range.....



What I’m suspecting
———————————————

There is a problem with the NMDA or with glutamate. Nearly all of my symptoms are checks with the “Low NMDA signalling”. But also I feel like it’s a excitotoxicity. Look at the huntington disease...

Also İ had seen that low nmda can induce excitotoxicty by the disinhibiton of GABA neurons. So I’m really desperate this point. I don’t want to harm myself further but I will probably not even able to talk a few months later.

I need a way to hard reset my NMDA system...

My symptoms are not as dramatic as yours, but I’m having the same ones! I’m so sorry you are going through this. It’s hell on earth.

 

[Enricks]

did you try to cycle l theanine





this can increase gaba , downregulate its receptor over time, and upregulate NDMA

I didn’t try it before. How much is the dosage needed for that effect? İf it’s not so much, despite the caffeine content of the green tea, I can drink that regularly.



Otherwise, I can buy a solgar l-thenaine.

I've had good results with Profrontal (Sarcosine + NAC) for anhedonia. This combo supposedly enhances NMDA signaling. I dont have anywhere near as bad of symptoms as you but if you suspect NDMA then it's worth a shot, IMO. It took a little over a month for me to notice improvements.

Sarcosine is not available here. In this country, I can’t order any med from the abroad without doctor privilege. I can’t order anything even from Amazon.



But, I can buy NAC easily from local pharmacy here. It’s cheap also. Just, I really don’t sure if this is NMDA hypofunction or hyperfunction. Progressive worsening + hypofuncion symptoms are seeming weird to me.

I’m guessing the OP read my Low NMDA Symptoms article...try E-Pharm Test Force II (DAA + Sarcosine), and one teaspoon of Diyesta

CEYLON Cinnamon per day. Cinnamon is both neuroprotective + enhances/extends NMDA-signaling!

Yes, I read your article, that blog absolutely is a blessing for me.



I have Ceyloan Cinnamon at my home. I had used it for a week or a bit longer but it didn’t do anything. Sarcosine or DAA is not available here. Or I can’t order them from abroad.



Do you have any opinion about what’s happening to me right now? I was always been very very anxious person before, Even, I can say that I was seeing some symptoms of glutamate excitotoxicity. But, days “after” the my antidepressant usage, I slowly losed my intellectual ability, motor functions, emotions, and my generalized anxiety...



It’s like that antidepressant deactivated one of my defence system and I slowly become intoxicated to a level that I don’t have enough excitatory signalling to induce any type of anxiety (NMDA internalization).



These are just my highly imaginative guesses, though. Maybe that’s just a simple nmda hypofunction.

My symptoms are not as dramatic as yours, but I’m having the same ones! I’m so sorry you are going through this. It’s hell on earth.

Thanks so much.

 

[Aflac94]

I has been quite different from the people on pssd community. My problems are more like a neurodegeneration rather than a sexual dysfunction.

List of the symptoms I have been dealing with:

- EXTREME Cognitive impairment (all the type of memories, memory retention, verbal processing, imagination, etc.)

- Fine motor skill dysfunctions. ( I was able to type with 10 fingers, and I was really fast. Now, I’m BARELY HOLDING A PEN. I forgot to how to move of my body. I’m retyping literally every word several times.) Because of it, I had to stop talking. I can't pronounce words correctly most of the time.)

- My muscles are trembling. This one the last symptom I have observed so far because it’s the sign of a really serious problem. They are constantly trembling(I feel in my inside) and sometimes I’m getting random shocks (myoclonic jerks, I guess).

- No emotion at all. Even the negative ones. (Again, I used to be very emotional person. And I was also a victim of serious anxiety disorder.)

- Zero libido

- Shivering. I’m much more sensitive to cold.

- General Fatigue

- Visual problems (I checked my eyes. I’m sure That’s absolutely because of the pssd.)

- Loss of taste and smell perception

- Muscle weakness

- Estrogen dominance symptoms ( fat on the belly, gynocomestia(unilateral), etc.)


Notes.
——————————————————

- I have been in this since a year ago.
- The med was Prozac.
- Everything started on the 3rd day with the symptom which is hypersomnia
- I totally used it for 20 days
- I didn’t use any med after that day or also I hadn’t use any med before that.
- I was completely functional and normal before the med
- I’m 17 and at 1.75 tall, 61 kg weight.
- I was using my English more correctly before that, But it made me really stupid that I can’t even use my native language proprietaly. So sorry ;(
- Caffeine and masturbation accelerating progress of the disease.
- Cyproheptadine didn’t do anything. Even on doses like 4 mg (I got serious hypoglycemia from that)
- All of my problems progressively worsening since that day. No windows at all. Muscle jerks and trembles are happening so frequent this week.
- That’s the result paper of my hormone test:

View attachment 1392
View attachment 1393
View attachment 1394


- Cortisol is on the lower range.....



What I’m suspecting
———————————————

There is a problem with the NMDA or with glutamate. Nearly all of my symptoms are checks with the “Low NMDA signalling”. But also I feel like it’s a excitotoxicity. Look at the huntington disease...

Also İ had seen that low nmda can induce excitotoxicty by the disinhibiton of GABA neurons. So I’m really desperate this point. I don’t want to harm myself further but I will probably not even able to talk a few months later.

I need a way to hard reset my NMDA system...

This sounds a lot like my pFS post crash state / symptoms. I never really had sexual symptoms. Never lost libido or erections ability. All neurological

 

[Area-1255]

I didn’t try it before. How much is the dosage needed for that effect? İf it’s not so much, despite the caffeine content of the green tea, I can drink that regularly.



Otherwise, I can buy a solgar l-thenaine.







Sarcosine is not available here. In this country, I can’t order any med from the abroad without doctor privilege. I can’t order anything even from Amazon.



But, I can buy NAC easily from local pharmacy here. It’s cheap also. Just, I really don’t sure if this is NMDA hypofunction or hyperfunction. Progressive worsening + hypofuncion symptoms are seeming weird to me.







Yes, I read your article, that blog absolutely is a blessing for me.



I have Ceyloan Cinnamon at my home. I had used it for a week or a bit longer but it didn’t do anything. Sarcosine or DAA is not available here. Or I can’t order them from abroad.



Do you have any opinion about what’s happening to me right now? I was always been very very anxious person before, Even, I can say that I was seeing some symptoms of glutamate excitotoxicity. But, days “after” the my antidepressant usage, I slowly losed my intellectual ability, motor functions, emotions, and my generalized anxiety...



It’s like that antidepressant deactivated one of my defence system and I slowly become intoxicated to a level that I don’t have enough excitatory signalling to induce any type of anxiety (NMDA internalization).



These are just my highly imaginative guesses, though. Maybe that’s just a simple nmda hypofunction.




Thanks so much.

NMDA hypofunction could be caused by excess Kynurenic Acid; this endogenous compound blocks NMDA receptors and causes Disorganized Thought Process. Schizophrenics have high Kynurenic Acid. Kynurenic avid messes with the Frontal Cortex. Causes poor uptake of neurotransmitters in frontal Lobe.

 

[Helen]

NMDA hypofunction could be caused by excess Kynurenic Acid; this endogenous compound blocks NMDA receptors and causes Disorganized Thought Process. Schizophrenics have high Kynurenic Acid. Kynurenic avid messes with the Frontal Cortex. Causes poor uptake of neurotransmitters in frontal Lobe.

that is because kynurenine bulds up when you are lacking Kynurenine monooxygenase

which is FAD enzyme, with a cofactor NADPH.

most PSSD people have very low b2 in blood , some undetectable. and some have very low NADPH.



this low B2 also stops from getting to vitamin k2 since k to k2 is fad enzyme., which increases calcium in blood which slows down metabolism, and this lowers estrogen, causing lack of emotions etc. and NMDA etc. noradrenaline


That is why Schizophrenics are given niacin, to increase progesterone which raises potassium, increases metabolism which raises estrogen and uses up free copper in the brain


other enzymes to get to QA use b6 active form.

 

[Helen]

@Area-1255 kynurenic pathway is important also to make picolinic acid. Which is responsible for zinc absorption. that is why some slow oxidizers have high zinc on their hairtest. since it is not bound to picolinic acid.


this is why I gave all this stuff in electrolytes protocol to support this pathway, first.

And loss of zinc is what is called pyroluria.



Kynurenine monooxygenase creates free radicals. and thus has to contain Glutathione reductase components, FAD and NADPH

thus if those are available , kyrurenine pathway can go forward, and create free radicals and agonize NDMA with quinolinic acid

 

[Helen]

this is why I mentioned pyroluria treatment for some people will get rid of alot of symptoms.

 

[Enricks]

@Helen @Area-1255

So, what should I do in order to fix my kynurenic pathway?
Menaquinone-7, B6, B2, B3? How much the dosage should be?
Will they be enough to increase kynurenine monooxygenase and reverse my progressive neurodegeneration?

I looked up to pyroluria symptoms but they didn’t seemed similar actually. I don’t even have any anxiety problem anymore, despite that I had serious problems before using ssri.

I also had used some zinc a few weeks ago (15 mg zinc sulphate, 1 week). It didn’t do anything.

 

[barbaar]

@Helen @Area-1255

So, what should I do in order to fix my kynurenic pathway?
Menaquinone-7, B6, B2, B3? How much the dosage should be?
Will they be enough to increase kynurenine monooxygenase and reverse my progressive neurodegeneration?

I looked up to pyroluria symptoms but they didn’t seemed similar actually. I don’t even have any anxiety problem anymore, despite that I had serious problems before using ssri.

I also had used some zinc a few weeks ago (15 mg zinc sulphate, 1 week). It didn’t do anything.

I'd say take a high quality b complex and Menaquinone-7. A few days ago I felt like I crashed back to square one but this has improved me back to near-baseline super fast.

 

[Enricks]

Okay. I made a order of a bottle of b-complex and menaquinone-7. I wonder if you have any more suggestion though.

This situation worsened as hell and I must stock some ideas before I will go full brain dead. I’m literally worsening day by day, it’s unbelievable.

 

[barbaar]

Okay. I made a order of a bottle of b-complex and menaquinone-7. I wonder if you have any more suggestion though.

This situation worsened as hell and I must stock some ideas before I will go full brain dead. I’m literally worsening day by day, it’s unbelievable.

Give the stuff you ordered a go, I think it should help.

 

[Enricks]

@Helen @barbaar

Today, I started to B complex and MK-7

These are what my b complex contains:

Thiamine hydrochloride - 50 mg
Riboflavin - 50 mg
Niacinamide - 50 mg
Pantotenic acid - 50 mg
Pyridoxine Hydrochloride - 10 mg
Cobalamin - 50 mcg
Folic acid - 400 mcg
Biotin - 300 mcg
choline bitartrate - 25 mg
Inositol - 50 mg

Also 100 mcg menaquinone-7.

Both of them, 1x per day.

my B complex contains titanium dioxide as additive, so should I do something about that? it’s glutamate reuptake blocker and have potent neurotoxic effects afaik. Also it has pro-diabetic effects too. Both of them are the worst thing I can get while now.

 

[barbaar]

@Helen @barbaar

Today, I started to B complex and MK-7

These are what my b complex contains:

Thiamine hydrochloride - 50 mg
Riboflavin - 50 mg
Niacinamide - 50 mg
Pantotenic acid - 50 mg
Pyridoxine Hydrochloride - 10 mg
Cobalamin - 50 mcg
Folic acid - 400 mcg
Biotin - 300 mcg
choline bitartrate - 25 mg
Inositol - 50 mg

Also 100 mcg menaquinone-7.

Both of them, 1x per day.

my B complex contains titanium dioxide as additive, so should I do something about that? it’s glutamate reuptake blocker and have potent neurotoxic effects afaik. Also it has pro-diabetic effects too. Both of them are the worst thing I can get while now.

It's probably better to get something without titanium dioxide to be safe. I don't know a lot about it but it seems especially TiO2 nanoparticles are a bad thing to get into your body. Titanium dioxide in our everyday life; is it safe?

 

[Enricks]

@barbaar I researched a bit, but I couldn't find any usable B complex other than this. If I ignore the titanium dioxide content, this supplements is way better than the others I could find, to be honest. So, I have to continue with it.

Anyway.


It's been 3 days, I don't know if it somehow affected me so far. Still have zero libido, terrible brain fog, terrible motor functions etc. Maybe emotional numbness bit worse now.


Despite that my situation worsening progressively just like how it happens in an neurodegeneration (I guess it's only happens when someone have excitotoxicity) I'm quite sure that I have very low NMDA. Thanks to Area1255, Now I know that Kynurenic pathway may be responsible for it.


Taking a B complex will fix it? It just seems bit much unrealistic to me. Is that supposed to be fix the pathway (KMO, NADPH etc.) or not?

 

[barbaar]

@barbaar I researched a bit, but I couldn't find any usable B complex other than this. If I ignore the titanium dioxide content, this supplements is way better than the others I could find, to be honest. So, I have to continue with it.

Anyway.


It's been 3 days, I don't know if it somehow affected me so far. Still have zero libido, terrible brain fog, terrible motor functions etc. Maybe emotional numbness bit worse now.


Despite that my situation worsening progressively just like how it happens in an neurodegeneration (I guess it's only happens when someone have excitotoxicity) I'm quite sure that I have very low NMDA. Thanks to Area1255, Now I know that Kynurenic pathway may be responsible for it.


Taking a B complex will fix it? It just seems bit much unrealistic to me. Is that supposed to be fix the pathway (KMO, NADPH etc.) or not?

I'm sorry man, I don't know. B complex just helps my fatigue and K2 seems to have pulled me out of a pretty bad crash. I'm still not fixed myself, although it has gotten a lot more manageable. Anyways 3 days is definitely too short to judge if it is helping or not. I'd stick to this for a while if you can.

 

[MNK99]

-B complex as well as eggs (raw eggs/ deyolked or one with yolk, several white), help digestion. --B complex and var helped. But did not cure, but was pretty good. even better not injured. I think helps fatigue too, as in wake up quicker. When I had chronic fatigue...... I don't know what would help except for a major detox - in my case water fasting.

-I think it helped fat metabolism... maybe bile acid production (I know Mg and Egg whites can help that part).
-Crash or mini crash less and less over time. No real crashes but some bad days for sure, but not only from PFS. Initially yeah, for months and months PFS was the main thing on my mind.
-Electrolytes (defunct) or TEI can help take all the things in unison, and will be tough at first, but mostly worth it.
-- Maybe things that block Cortisol or make you run on cortisol can work better or worse on B complexes. Not sure. mine was similar to Barbaar's.
--It's also in Min Plex B in TEI I think as well as several other supplements they have. Anti prolactin and dopamine affecting (the receptors...? I forget). It's like dostinex.......
-but "natural". ---also many B 50 have choline, and various B's in similar but different ratios.

--No matter how much better I got... I think NDMA things still messed up my stomach such as Collagen. Sometimes not so much, but definitely even with
perfect or near it digestion on day 1 day 3 day 4 day 5 for instance, taking it on day 2 or day 1 night would mess up day 2's digestion.
--NDMA antagonists such as the weak Mg and the stronger Li Orotate helped me. ---> I used those to lower heart rate, and also get rid of aggression/irritation/ or to take off the edge from a stimulant, as well as sometimes to help sleep.
--I probably have whatever mutations make it so that NDMA antagonists are needed and not NDMA agonizing things. --maybe that will go away/ who knows.