Nevermind. Thanks for reply anyway. I will definitely continue to take a B complex for sure. I think the Nicotinamide takes a big role in this disease, as what Helen has just said.
You right. Electrolytes seems also important. I had seen several posts on pssdforum about mineral deficiencies like copper or sodium.
I'm not into taking any receptor agonist as they are not a cure and they risky so much.
What I think is that I have very low NMDA. A NMDA antagonist would kick me hard.
Now, there is only one thing I'm caring now, and this is kynurenine pathway. I'm highly suspecing that fluoxetine wrecked my KYNA/QUIN balance.
New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio. - PubMed - NCBI (Please look at it!)
As you can see here, Quinolinic acid further metabolized to the NAD+. This may explains why some pssd sufferers have low NADPH and picolinic acid (Helen's quote). Also it may explains why most of the pssd sufferers getting some improvements from niacin supplements. I'm not sure if these two substances are in the same pathway, though.
The studys says that KAT is upreguated and KMO is downregulated. So I think I have to do the opposite of it. But I must be careful because from what I read, quinolinic acid an its precursors are relatively neurotoxic as they are mostly excitatory substances.
@Helen @Area-1255
This is very promising. I think this will be the last attempt to find a cure before I will make something bad to myself. But I'm very hopefull to be honest. I may just need to know if I can heal %100 or not.
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I read it several times.
B2 - ✓ 50 mg
B3 (niacinamide form) - ✓ 50 mg
B6 (pyridoxine hcl) - ✓ 10 mg
K2 - ✓ 100 mcg
AFAIK, B3 will synthesized to NAD+ and so as well to NADPH
NADPH - ✓
FAD - ✓
I looked up to pyroluria symptoms but I have only 6 of them(42).
Pyroluria Questionnaire from The Antianxiety Food Solution - everywomanover29
Even, most of those are not in the common symptoms. Also, I may had telled wrong. I have no anxiety at all. This disease made me free from my every emotion including negative ones.
By the way, still no improvement. My cognitive and visual abilities still worsening.
I couldn’t understand what should I do on the electrolyte protocol.
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you should test your folate metabolism and b12 metabolims , SaME also
since dont forget to make glutamate and have NMDA signaling
you need to convert histidine into glutamic acid.
for that you need tetrafolate,
and if you have problems with making tetrafolate, you can have low glutamate.
Look up the thread where I posted blood results for PFS.
all of them show zero folates, and problems with folate and methionine cycle.
I assume this is because of lack of b12 recycling from methionine synthase reductase
My folate is at 7.98 ng/mL, in the range
Also my b12 was over the 1000, while I was using methylcobalamine( I started it after the pssd). And after it reduced to about 500 on the second test.
I don’t think I have any chance to check my SaME levels. Any suggestion to improve methionine cycle?
Again, I read all of the topic several times and I couldn't find any other thing that can help me.
I started this journey with reading medhelp stories, or some blog posts about how much fucked up SSRIs are. that times were horrible. I felt so lonely. And, 1 year later, I'm here. Considering all the theories I have seen until now, I think this is amazing to come up to this point. It would be tragedy to giving up and just leaving this world now.
But, unfortunately, this may will be necessary. Not only the pssd itself, but the school and family makes it life harder to cope by. Yesterday, I argued with my family and I used some very hard words. It's very hard to not being able to cry or feel guilty about something. Only thing left from my old self is bit of my anger. I don't want to live like a monster anymore. I don't want to upset them further.
Anyway.
I want to look at this in a basic way. Fluoxetine upregulates KAT and downregulates KMO. This doubles the effect, as there will be more substance and more enzyme activity.
Why don't these enzymes return to their normal? Can I correct the balance with a KMO inducer and a KAT inhibitor? If so, where can I find them?
I started this journey with reading medhelp stories, or some blog posts about how much fucked up SSRIs are. that times were horrible. I felt so lonely. And, 1 year later, I'm here. Considering all the theories I have seen until now, I think this is amazing to come up to this point. It would be tragedy to giving up and just leaving this world now.
But, unfortunately, this may will be necessary. Not only the pssd itself, but the school and family makes it life harder to cope by. Yesterday, I argued with my family and I used some very hard words. It's very hard to not being able to cry or feel guilty about something. Only thing left from my old self is bit of my anger. I don't want to live like a monster anymore. I don't want to upset them further.
Anyway.
I want to look at this in a basic way. Fluoxetine upregulates KAT and downregulates KMO. This doubles the effect, as there will be more substance and more enzyme activity.
Why don't these enzymes return to their normal? Can I correct the balance with a KMO inducer and a KAT inhibitor? If so, where can I find them?
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we tested several people for PSSD, and all of them have zero vitamin b2 in blood, now read my messages again.
Follow talkingant,
mine were normal....
Damn, B complex not doing any shit. It has b2 too.
I need some real stuff. I want to directly target the kynurenic pathway, if there is no any other main reason that keeps kynurenic pathway in this imbalanced state. KMO inducer and KAT inhibitor would be nice to try.
Nevermind
@Area-1255
I just wanted to thank you for your helps before going. Both, for the idea and your blog.