To be honest, i try to separate things as much as possible so I recommend kelp pill if you want Iodine. Multis have things I try to avoid.
- Messages
- 2,590
Where does it show RU blocks AR in particular? Also, people felt better baseline after RU not just on as well
- Messages
- 5,415
RU is a progestin which acts on progesterone different ways. agonizing when progesterone is missing, and antagonizing when it is not,
and blocking cortisol, so lowering CBG,
RU has a possibility of a cure. Since if it blocks cortisol, then it lowers CBG and allows progesterone to retain potassium. this then allows 5AR reductase to start converting testosterone which is high to DHT in CSF.
This is why poor mini experienced what upregulated androgen receptor feels like
Last edited:
- Messages
- 5,415
- Messages
- 2,590
Interesting however why did DHT increase in that study though wihile taking RU? While taking fin and anavar both lowered DHT if they all block AR.
NVM just saw your second post
Update:
I am finally 100% normal. This is such a relief. It could fade away but I don’t think so. My current regimen is one drop of avodart every 5 days. My plan is to stay like this for months if not longer and then very carefully start expanding the duration, like over six months or a year or something.
Couple thoughts: really interesting how high the testosterone went with such a low dose of avodart. Although my testosterone was 1200-1300 when I checked pre-pfs. The shbg was really high couple weeks ago. I thought it could be related to fluctuating levels of T because I was taking 2.5 drops every 12 days. ( it was high pre pfs too) I thought a lower dose more frequently was better and I quickly noticed the improvement. This regimen definitely improved me and this last month w adjusting the dosing got me to 100%. I feel great! Strong/ strong erection like the old days. No PE. Not even close. Geez that would come up too often and it’s so demoralizing. I feel strong, good weight. Great mood. Great morning wood. Not taking any other supplements. Not sure if Sam-e helped initially or not. I thought about doing this so long ago but was afraid of the pills. I hope it could help others. My DHT was high ( not sure if your dht is normal or low , if it will work). and I totally noticed an improvement even transiently when I started. It’s hard to tell if you are over or under dosing.
I think using finesteride to do this may be problematic bc of shorter half life and dht would fluctuate too much.
I am finally 100% normal. This is such a relief. It could fade away but I don’t think so. My current regimen is one drop of avodart every 5 days. My plan is to stay like this for months if not longer and then very carefully start expanding the duration, like over six months or a year or something.
Couple thoughts: really interesting how high the testosterone went with such a low dose of avodart. Although my testosterone was 1200-1300 when I checked pre-pfs. The shbg was really high couple weeks ago. I thought it could be related to fluctuating levels of T because I was taking 2.5 drops every 12 days. ( it was high pre pfs too) I thought a lower dose more frequently was better and I quickly noticed the improvement. This regimen definitely improved me and this last month w adjusting the dosing got me to 100%. I feel great! Strong/ strong erection like the old days. No PE. Not even close. Geez that would come up too often and it’s so demoralizing. I feel strong, good weight. Great mood. Great morning wood. Not taking any other supplements. Not sure if Sam-e helped initially or not. I thought about doing this so long ago but was afraid of the pills. I hope it could help others. My DHT was high ( not sure if your dht is normal or low , if it will work). and I totally noticed an improvement even transiently when I started. It’s hard to tell if you are over or under dosing.
I think using finesteride to do this may be problematic bc of shorter half life and dht would fluctuate too much.
- Messages
- 2,590
Crazy man, I guess dut can really balance your metabolism if microdosed properly and you actually know your hormones. I think the ideal doses they prescribe is way overkill. Dut was always preferred over on the old forum PHG I used to be on (Swiss temples) than fin and many of them did not get sides from it I assume do to much more stable levels from the half life.... Of course they are both bad but it is interesting nonetheless.
- Messages
- 5,415
He keeps lowering the duration between dosages. I hope soon it wont be 1 drop a day. as we saw from this all experience, the body keeps adjusting and moving.
It would be nice if it stays in one position, but it seems moving.
SO it would be nice if it stays the same over a long period of time. then we can say, that avodart is just misdosed. And it is a good drug for high DHT people, but dosages are totally not correct.
Last edited:
Just FYI...Actually on May 18th I reported DHT 77 5 days after dosing. I rechecked after about the same time and it was lower at 66, so I don't think I was becoming tolerant or even resistent to Avodart. Now dosing 1 drop at 5 days and previously was at 2.5 drops at 11-12 days. So I haven't continued to go up on the medication.
I do feel better than I have ever felt ( PFS). I never felt 100% normal, and I do now. At this point, I do believe the drug had changed me ( us) and this could be the eipigenetic change previously discussed. So for me, I have to be on the Avodart ( even micro dose) to feel " normal." As I said, I will plan to increase the time between dose very slowly after I am absolutely certain the recoovery is durable. Hopefully it will continue! I'll continue to reports back every couple weeks, as I have been doing.
- Messages
- 5,415
Avodart has 5 weeks half life. taking 2 drops for 11 days, and taking any drops for 5 days should be a huge difference and an increase. Because it accumulates. So taking avodart 2 drops for 12-14 days, and taking avodart 1 drop for 5 days will result in quite substantial increase of dosage in 3-4 weeks
but in any case, I 'm cheering for you that you can stay steady on some dosage and not move. That would be good for you. Good luck, man.
but if you happen to move and this dosage for some reason won't work. You need to reconsider this stilt
Last edited:
I’ve heard them say that as well, and I don’t understand how that’s a possibility, right? 5ar1 is most active in the brain I thought. That is the key differentiator between fin and Dut is 5ar1 inhibition. I just don’t see how it can’t be worse than fin, and yet they all swore that Dut didn’t cause sides anywhere near as bad as Fin. Head scratcher.
@Jack17 so awesome man. Congrats. Love to see this working.
- Messages
- 5,415
I hope you realize that he took avodart originally and not fin. And he felt good while on avodart before. He crashed when he came off. So when he went back on he is ok
But if fin does inhibit only certains 5ARs and dut inhibits all of them , then fin can create certain imbalances among them possibly.
I still don't get how fin does not inhibit 5AR1 though, since in Melcangi study this is exactly what is not working in CSF of PFS victims.
Also don't forget we have the same crashes from RU58841 which does not even touch 5AR, it just blocks androgen receptor causing the same crash after you come off.
SO it is obvious that changes while androgen deprived is what is causing this.
Also I think people before they ever touch fin or dut, should always test their DHT levels. Since I think people who would benefit from the drugs, are those with Gilberts syndrome where they lack glucorinidation and their DHT levels and level of all other 5AR metabolites like 3 adiol are extremely high.
Of course it is better to try to support glucorinidation at first . But I saw folks take fin with low DHT levels which makes zero sense to me and they obviously crash while on fin.
Also I want to mention that if people have problems with glucorinidation then I assume their 5AR gets closed down a little anyhow.
So I would prefer to deal with glucorinidation, which actually increases 5AR in this case. and not go on fin or dut which closes 5AR and deals with high DHT and 3 adiol this way, since 5AR is used in tons of reactions in the body, in cortisol and aldosterone systems. in GABA systems. and obviously if you introduce 5AR inhibitor, those systems get affected. SO potentially this is a mechanism why the body is trying to adjust and move.
Last edited:
Aleksandr
Well-Known Member
- Messages
- 1,285
Whats this PHG forum? Are you the swiss temples guy?!
Trump_1776
Well-Known Member
- Messages
- 403
It was a private homosexual hair forum
Trump_1776
Well-Known Member
- Messages
- 403
Now all we need is a replication!!
jinstewart
Well-Known Member
- Messages
- 189
I'm tempted... I'd like to wait a few months and see though if it sticks and/or can be weened off.
I do not have the balls Jack17 has!
...Random question, what does avodart taste like? Is it horrid?
Trump_1776
Well-Known Member
- Messages
- 403
Tastes like vagina