METHYLATION PROTOCOL

bruschi11

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want to point something about this threat.
From Melcangi study, we can read that the issue is the 5 alpha reductase enzyme who is missing in tissue of people.
It is missing in different quantity in liquor brain and other tissues depending from the person who got tested.
So, the issue is not about ARs but about 5alpha reductase enzyme not working properly and that is why we have suppressed DHT metabolites.
This is the issue with pfs, no other bullshit

You and researchers don’t look at this systemically. From this non stop 5ar enzyme perspective.

Helen knows a lot more about systemic illness Than melcangi. Melcangi looks at statistics. Helen looks at whole system.

All that melcangi is good for us feeding us some information. So Helen can get info from his studies to dig deeper. Because Melcangi is about 2 feet deep and Helen is 1000.

People go at this and have been cured in so many different ways. Majority go by making system strong whether it’s via nutrition, hormones, and so on.
 

wuf

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You and researchers don’t look at this systemically. From this non stop 5ar enzyme perspective.

Helen knows a lot more about systemic illness Than melcangi. Melcangi looks at statistics. Helen looks at whole system.

All that melcangi is good for us feeding us some information. So Helen can get info from his studies to dig deeper. Because Melcangi is about 2 feet deep and Helen is 1000.

People go at this and have been cured in so many different ways. Majority go by making system strong whether it’s via nutrition, hormones, and so on.
Sure. You're right.
But now Helen thinks that the root of pfs is NADPH.. So why not to test it?
 

Helen

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Sure. You're right.
But now Helen thinks that the root of pfs is NADPH.. So why not to test it?


Wuf, I dont think that root is NADPH, I said that it is a possibility , and I posted different possibilities which need to be tested.

I will outline everything I posted before in one post.
 
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bruschi11

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But I know also tons of people who ran Freddd protocol and went thru crzy detoxes and got cured. from crazy conditions.

Like gbold I know many who got better running similar thing here.

I’m not running it exactly. But finally getting to methyl/ adeno b12 today. After getting in b2 b5 biotin the last few days. The b12 is hitting me and putting me into one of craziest detoxes I’ve ever had.

This is really how I healed last fall. I didn’t take biotin and when I went deficient and really needed it I shot myself in the foot. I started using Dhea instead. And I think I was dumping too much iron and copper from liver into serum. I then donated blood and had worst crash of my life next to pfs. This was all last December.

As bad as the detox is… I believe this is my only escape route. My main toxicity I believe is oxygen. Usually when body starts handling oxygen it can do so pretty quick if you put the right things inside it. Trying to think optimistically here.

I think body really gets hit by h202 as methylation turns on.
 
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bruschi11

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What a lot of people don’t realize is…. B12 literally moves methylation from SAH to Methionine assuming copper (biotin) and zinc are ok. FAD (b2 and moly if needed) is up. NRF2/xc works (b5… active form pantithene May be needed.)

The science never siezes to amaze me. I’m so fascinated by it. As sick as I’ve gotten and been. It’s all so real.

I told someone I’m working with the other day. “I had to keep going. Even though I got way sicker than before. I got well with the same illness. I know this has been the same illness. I just have to get the science to cooperate.”

And it’s true. The aminos have been a mess ever since December when I crashed. The aminos govern the cell. But minerals play a major role in governing aminos.

It’s all so tricky for the common Joe to pickup. But it’s real. The power methylation and of mineral balance is something you’d never believe until you experience it yourself.
 
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bruschi11

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It’s not “detox”… it’s literally body just using up oxygen with iron and copper creating h202. That’s what happens when you have crazy reaction to b12s while biotin b2 b5 zinc manganese electorlytes are ok.

I’m starting to think FAD NAD balance is important where NAD is more histidine FAD more cysteine. Yes you need FAD for histidine but it’s not gonna get you to histidine by itself and it’s always gonna produce more cysteine.

That’s what I realized today forcing more b2 when I really didn’t need it this morning.

We need copper for histidine. So that’s why Biotin is so nice here. Chromium too can help for copper but chromium does upregulate NRF2 and act a bit like b5.

Methylation protocols purpose really is zinc finger and cu ghk at end of day. But most don’t have to take this approach I don’t think.

Gbold “copper histidine is what got me better end of day.” He said something like that. Well methylation protocol is in charge of getting to histidine and copper.

Last fall I’d have days where I’d give copper and one of those ahk or ghk patches. Giving histidine copper essentially and I’d feel so much better. But at the same time b12 was the biggest key to moving forward.

I was copper toxic from dumping at the time. Until I wasn’t and I severely needed biotin. Opted for Dhea, 6 weeks later I give blood. And boom I’m battling Parkinson’s or MS essentially just like that.

Posting a little diagram here that’s awesome. See how propionyl CoA is next to cysteine down there. That’s biotin. Biotin moves cysteine for b12’s use from there.

GRJ “FAD recycles b12.” I’m sure he’s right but if someone has cysteine issues… maybe long term FAD lowers b12. 2021 2.5 months of taking b2 what happens? Cobalt (b12) drops in hair. It’s really not all that simple mr GRJ.
 

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bruschi11

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I really think b12 is the big one when it comes to all this. For me. Oxidative stress illness.

It’s like b2, b5, biotin. They’re all just there to allow b12 go in and do it’s job.

I took too much biotin Sunday and again last night. Both were horrible things for me really horrible. Gluth goes down. Crazy h202 issues.

At this point in time, the goal is getting to b12. Biotin is a bridge from b2/b5 to b12.

Biotin moves cysteine… but what if you move too much cysteine and can’t make gluth?
Gluth goes down? System xc goes down. Cystine gets stuck. Now you’re just dumping copper without making gluth. That’s the worst thing you can do.

Now you’re stuck at Cu2 and that makes sod malfunction. Honestly that’s probably the sod dysfunction they talk about in ALS. Cuz SOD needs cu1.

My crashes the last 2 years. It began 3 weeks ago 2 years ago really. All these crashes. They all involved copper dumping. Oxygen therapies were horrid. It really has been combination of oxygen therapies and copper dumping… both with methylation down- that killed me.
 

bruschi11

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B12 retains coq10… really the center of glutathione recycling.

So b12 really is both cysteine and histidine. It helps create both NADH and NAD+.

Honestly think it’s something you need or you don’t. Like I did not need b12 when cobalt was good in hair. Some Lithium helped to help b12 work . But it wasn’t until I saw cobalt dying in hair until I needed it. This was late 2021… never really got b12 going until fall 2022.

Balancing b12 and biotin is very important in my eyes. Biotin (assuming zinc sufficiency) gets you to citrulline. Citrulline without Arginine is a poison. You have to get to Arginine from citrulline.

Glutathione recycling + magnesium and aspartate (active b6) gets you there. So b12 getting to coq10 can be big for the gluth recycling part. So can b5 , vitamin E.
 

bruschi11

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Nitric oxide production, which happened the last two days here via biotin b5, badly needs BOTH b12 and manganese.

I think b12 helps handle carbon monoxide. Manganese/ ornithine handles both carbon monoxide and peroxynitrate.

That’s how I’m seeing it. Honestly feel like I’m dying tonjght but better than a couple hours ago.

Ray Peat hated NO production but there’s no way to fix a person without normalizing NO. You want balanced NO. Maybe low end of range is better. But in order to tolerate body’s own NO production. You need manganese you need b12.

No wonder why I handled NO production extremely well in 2020. I had high manganese in hair and b12 (cobalt) was high end in hair as well.

What’s funny is…. The following months after fixing NO production in 2020… manganese dropped in hair. I’ve known that. But woww… so did cobalt. Both dropped by A LOT.
 

bruschi11

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Freddd in the Phoenix rising forum includes carnitine in his big 4 next to methylfolate and two b12 adeno methyl. Carnitine was taken during a few of best years of my life… long before I became deadly ill a majority of the last 2 years.

Carnitine is allowing me to take biotin in heavy doses 4mg yesterday. And b12 (GRJ’s stuff). B2 makes methylfolate and initially carnitine is making it so I don’t need b2/b5 at allll. Probably taking demand off PDH. BUT I really think I will start needing b2 shortly if not today.

I had no idea what I was doing in May. But b12 biotin allowed me to take b2 and it cleared brain a ton one day. Didn’t realize what I was clearing was oxygen… the next day I do ozone and get into the biggest hole of my entire life.

This entire summer was fight for my life and I truly believe the true “toxicity” has been oxygen.

Need to keep creating electrons. I believe “ATP generate” on my rife machine while simultaneously using a red lamp sauna could help here. I believe Electroconvulsive therapy helped in mid 2022 for this reason.

D-ribose, ALA , TmG can support. Lots of milk, fruit, meat.

B5 (LOW dose), zinc/manganese will be needed here the latter two maybe higher doses. But it seems carnitine takes demand off manganese.

A little copper may be needed. Just creating so much histidine glycine I believe it’s being used hence my histamine issues… although the histamine has been a lot worse.

This biofeedback device is really incredible and helping me get this altogether. Will use weekly for a bit and I’m considering breaking the bank and buying my own. When well enough becoming a practitioner make a little side job out of it. Technology is incredible.

I hope it’s not too late. I don’t think it is but who knows. I worry about brain barrier. But gotta just execute and block out that noise.
 

bruschi11

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“A little copper may be needed”… took hours to realize absolutely not.

But b2 needed to go in and is effective right now. I believe b2 and b5 are the next steps now that b12, biotin are in post carnitine loading. Demand was psycho on biotin initially before b2/b5 could go in.

That makes me think…. Maybe chromium can support both b5/ biotin/ copper. It absolutely did in 2020. That will be next thing to try with some vanadium.
 

bruschi11

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Everything telling me carnitine needed for b5 metabolism. Carnitine gets pantothenic to pantithene which gets to CoA.

So biotin —> lysine—> carnitine plays gigantic role in using pantothenic acid for pantithene/ gluth recycling/ CoA.

It’s funny this last week I just said to myself “why does biotin feel like I’m making more glutathione.” Well that’s it.

I think what I did was inflate carnitine a bit (needed.) And then getting biotin in just kept carnitine production up more.

It’s been a disastrous summer physically. But I’ve been feeding b5 in some way or form since April. Heck even March I gave a little. And now my biofeedback readings continuously show b5 pooling… why ? Because the process requires carnitine for b5 metabolism.

I honestly don’t think I’ve been getting to carnitine too well via biotin. Until I gave some carnitine. I don’t think I need to give much but a little bit of topping up of carnitine is required.

Another thing I learned is how pantothenic acid is created in the folate cycle. Histidine helps to make pantothenic. Sure a little pantothenic supplementation can help. But I have to be careful there. Honestly think if histdine is working… we are making a lot of pantothenic.

Last week I really got histdine working… as shown in biofeedback. And yes I gave some pantithene. What happens? B5 goes high.

For the first time I tested CoA. It was low. FAD and FMN were low. All cuz of the high b5. High b5 kills CoA!!

I have purchased my own biofeedback device. The indigo and will have on hand within a week or so. I used this for the first time last week and I love its views of amino acids, CoA, and minerals in comparison to the other machine.
 

bruschi11

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Crazy stuff this week. I gave citrulline stupidly last weekend. I was shooting for copper but that was silly. Biofeedback shower high citrulline low FMN low arginine.

I’ve realized basically that increasing biotin/carnitine/ active b5 depletes FMN.

FMN is step one NADH in electron transport chain. B2 (precursor to fmn) always saves me in past. This year not so much. It’s helped a lot but I’ve been dying . The whole system needs to be corrected this time.

So it’s clear now… my neglect for iodine/ selenium (really looking at selenium specifically) converting b2 to FMN has been really pathetic on my part.

I’m realizing some people just really need to get to FMN and not even take b2. I have a friend whose benefiting like crazy from selenium. He had high b6. FMN activates b6 with magnesium and zinc.

Zinc has been weak to me. But after giving selenium and b2 ? 100mg of zinc, which I know is a high dose, put me in craziest detox reaction imaginable. It’s the b6 being activated.

My biofeedback machine is here and just needs to be activated so I can use on myself. I am beyond excited about it. Being to measure nutrients and enzymes aminos minerals daily is a dream I never though could be real. And it’s going to start today or tomorrow for me.

When I look at this all I really see glutathione production and recycling shaping the urea cycle. And I also see how thyroid takes iron that hisitidine is dumping into serum from hemoglobin and thyroid is putting iron in liver for hormones to be made.

This is why thyroid increases hormones in many. You’re putting free iron in the liver where the hormones are made.

I think the problem is when there is no free iron. No free iron? Thyroid can cause iron deficiency in serum. So thyroid really needs histidne working.
 

bruschi11

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Crazy last time I wrote here was 3 years ago almost. 2.5. Long time. I was all over the place. I was really getting sick around then.

But here's a post from Freddd that talks about just how bad he was and what he did....

For starters, have you looked at the symptoms list over on the BASICS thread? These are the list of symptoms that generally go along with these listed diseases AND for the most part, are capable of repair to some extent up to 100%. A new version with nutrients that repaired them will be posted soon. The things we call diseases, syndromes (probably more accurate), and so forth. So on May 20, 2003, I had 200 symptoms of the 300 list, and about 300 on a prototype 400 list which really gives more detail but doesn't change anything. It may make finer distictions to be made. I weighed more or less 285 pounds. My abdomen was swollen and hard like a basketball with fluid. I had high blood pressure. I had trouble breathing from the pressure. My heart had trouble beating from the pressure. My doc called it congestive heart failure. My top of leg thigh muscle was the thickness of my thumb. I had massive muscle atrophy over my whole body. I was skin and bones under the watery fat. I floated with my head completely out of the water, who needs a life jacket? I had IBS, FMS, CFS, (ME symtoms but not diagnosed in the USA) severe chronic pain, RSD, Subacute Combined degeneration, sleep disorders, hormone disorders, disordered disorders, autoimmune issues, at one point I was falling and close to a wheelchair. I had no balance for 17 years. Exercise intolerance, MCS, asthma, allergies, dozens of kinds of pains, multisensory hallucinations (no delusions, just neurological noise manifesting as hallucinations from smell to vision and hearing and taste and touch. I could go on for pages like this just what I had. I haven't seen anybody here sicker with more things wrong though there are an unfortunate set that approximately equaled my degree of dys ease. I had been treated for dozens of things by approximately 100 doctors and not one of them succeeded. Oh sure, the Pain Clinic stepped in 2001 and gave me enough morphine I could manage a decent night’s sleep for the first time in 30 years. I slept 16 hours that first night. That was most helpful symptom management, but not healing.



I would have been long dead at this point, after a short stint in a wheel chair, if I hadn't healed substantially. That list of diseases, CFS, FMS, Supra Nuclear Palsy, Parkinson's, MS, Subacute combined degeneration, ALS, for instance, includes the diseases in which studies show depressed CSF levels of cobalamin, and additional studies have also identified elevated MMA ANDOR HCY. Other studies have shown various neurological responses with all these various people to B12s given in various ways and trials. Since most of those were 3 months or so, no healing occurred. Do you know what the difference is between MS and SACD? Let’s see. With MS “b12 deficiency is ruled out” by having a serum level over 160pg/ml (PA threshold level). However, as MS also is known to have a CNS deficiency of b12 how does a ridiculously low threshold on body level rule out b12 deficiency? Seems contradictory to me. Also, lucky me, SACD has approximately equal bilateral damage while MS tends to be more one sided. Did you know that MS responds to the Deadlock Quartet just the same as SACD. Both MS and SACD have demyelization in the cord and brain. Some of this is permanent damage and some can be repaired. I’ve managed to repair about 75% of the SACD damage and holding. Also, I lost 85 pounds of water. I didn’t diet. It’s the same color it always was. I then lost 40 pounds of fat and put on 40-50 pounds of muscle. All of that occurred with the Deadlock quartet, in stages mapped out near the beginning of this thread. I no longer have CFS, FMS, IBS, RSD, asthma, MCS, seasonal allergies, daily vomiting, body wide inflammation, most of the peripheral neuropathies (hard to tell the details when the spinal nerves are not working right), congestive heart failure is gone, exercise intolerance is gone, balance is largely back. I am no longer diagnosable with any of these things because I am down to a handful of symptoms, mostly attributable to a car crash and other physical traumas along the way, and SACD damage that just keeps on giving.
 

bruschi11

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@bruschi11 I don't get it so he fixed all his issue with B12?
He considered the “deadlock quartet” adob12, meb12, carnitine, methyl folate to be his core.

But he was on TRT and started it a few years before b12s etc.

He needed the rest of nutrients. Like staples zinc ca mg b complex choline inositol. Few years in lithium was huge for him like 20mg daily.

He really thought fluoride was a big problem as his dad was a dentist.

One thing that gives me promise. He said in 2009 that he started in 2003 with b12s etc. but he said in those 6 years? He only healed during 2 of the years because the intricacies and learning. And I just hope I’m in that same ballpark.

My first time of healing with b12 was late 2022.
 
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