Minoxidil downregulates 5ar2 gene expression

[D4n]

Hi all, This study https://hrcak.srce.hr/file/284618 shows minox downregulates 5ar2. I used minox about 3 years ago and since then have suffered with most of the mental sides of pfs( consideribly better of late) still lacking libido though which is annoying. Hope someone can make better sense of this study. Thinking about getting a hair test soon to see where I’m at.

 

[Flynn]

Just out of interest what are you sexual side effects in detail from taking Minox, how did you take the minox?

Have you tried increasing testosterone levels (I'm not saying this is the problem, just interested in if it has no effect on symptoms).

Study does seem to suggest minox down regulates 5AR expression which is very interesting. Only by 0.22x though if I read correctly? of course this could be different depending on dosage, length of exposure and cel type

 

[D4n]

My sides are more the mental aspect of libido for example hard to get aroused, little lack of sensitivity pretty sure semen was watery on minox too, fine now though. Erection quality good. I used it topically in facial areas to increase facial hair growth lol. I had my testosterone level checked and it was in the 700s so I don’t think that’s the problem, I also gain muscle fairy easily when I got motivation for the gym. A google search backs up this lack of libido with minox. The potassium and 5ar link to it seems a bit suspicious.

 

[Flynn]

My sides are more the mental aspect of libido for example hard to get aroused, little lack of sensitivity pretty sure semen was watery on minox too, fine now though. Erection quality good. I used it topically in facial areas to increase facial hair growth lol. I had my testosterone level checked and it was in the 700s so I don’t think that’s the problem, I also gain muscle fairy easily when I got motivation for the gym. A google search backs up this lack of libido with minox. The potassium and 5ar link to it seems a bit suspicious.

OK so you have recovered libido, arousal now? yes it seems very suspect.

 

[M_Mitchell08]

My sides are more the mental aspect of libido for example hard to get aroused, little lack of sensitivity pretty sure semen was watery on minox too, fine now though. Erection quality good. I used it topically in facial areas to increase facial hair growth lol. I had my testosterone level checked and it was in the 700s so I don’t think that’s the problem, I also gain muscle fairy easily when I got motivation for the gym. A google search backs up this lack of libido with minox. The potassium and 5ar link to it seems a bit suspicious.

Just curious, what do you think seems suspicious between the 5ar and potassium link? Wasn't sure if you were referencing my post, because I am not sure I was even making sense - just sort of throwing stuff out there to see if others had better insight. How long did you use Minoxidil for?

 

[D4n]

I’ve had dry flaky skin on my face quite regularly since, which could be the 5ar2 link to sebum production.

 

[M_Mitchell08]

I’ve had dry flaky skin on my face quite regularly since, which could be the 5ar2 link to sebum production.

Gotcha! What did you mean by the potassium / 5ar link being suspicious? Also, how long did you use the product for?

 

[D4n]

I used minox for roughly 2 months I’d say, made some decent facial hair gains on it lol. It’s a potassium channel opener, I’m not sure what it does or weather it decreases or increases potassium, and potassium levels seem to affect progesterone levels, 5ar is linked to Dht. This is why I made links to pfs or pas to minox use( I could be completely wrong in what I’m saying so don’t count on it lol)

 

[D4n]

Minox is also a blood pressure medicine. This is quite interesting re aldosterone... “If decreased blood pressure is detected, the adrenal gland is stimulated by these stretch receptors to release aldosterone, which increases sodium reabsorption from the urine, sweat, and the gut. This causes increased osmolarity in the extracellular fluid, which will eventually return blood pressure toward normal.”

 

[Flynn]

I find it hard to believe using something topically could have such an effect on libido/sex drive. Like how is a large enough concentration being absorbed into the blood and then messing with 5AR in the brain. I don't doubt it, as I know too well how crazy side effects can be (Accutane user) but seems crazy. When something is taken orally if makes a lot more sense

 

[D4n]

It is hard to believe, maybe absorbed through the arteries in the neck running to the brain. What is weird is the only time I have a little amount of sex drive is that day after excessive alcohol consumption

 

[D4n]

Don’t know how credible this study is but I might run a cycle of r-Andro Androsterone a Major Factor in Sexual Desire - SuppVersity: Nutrition and Exercise Science for Everyone

 

[TubZy]

Hi all, This study https://hrcak.srce.hr/file/284618 shows minox downregulates 5ar2. I used minox about 3 years ago and since then have suffered with most of the mental sides of pfs( consideribly better of late) still lacking libido though which is annoying. Hope someone can make better sense of this study. Thinking about getting a hair test soon to see where I’m at.

Damn that is very good find, I will add this to the study section as well, thank you

check out the links in my sig when you get a chance

 

[D4n]

Thanks, great forum by the way