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<QUOTE author="BeLikeWater" post_id="4401" time="1510913047" user_id="112"><s>
BeLikeWater post_id=4401 time=1510913047 user_id=112 said:
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Can we relate to the thread theme dont interfere.<br/>
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For example take exogenous test or increase DHT with things like Sorghum end up with better 5arw activity (better sebum) but feeling worse mentally, brain fog, etc... Seems the key here is upgrade 5ar1 activity to have DHT in brain, allo, etc...
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This is related to this thread and immune response. PFS puts you into alkalosis and this does not allow immune response to happen. Usually when you get sick, you go into acidosis. In PFS you cant do it. And thus you are getting chronic infections, which when you start fixing alkalosis you will FEEL so much it is not even funny. You will be sick big time.<br/>
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taking exogenous test or DHT causes you to downregulate 3 beta hsd and 450scc. Which is already downregulated. thus your iron is not being used HENCE no immune response.<br/>
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Same happens with POIS people. when POIS people get sick, their pois disappears. they dont get sick often since they are in alkalosis. In alkalosis there is no immune response. And when you have flu body tries to go into acidosis , which lowers cortisol since acidosis tanks potassium in the cell. When potassium is tanked , cortisol needs to be broken down. and it is broken down by 5 alpha reductase 2. Thus its activity goes UP and most PFS and POIS symptoms disappear. The only problem is this will raise progesterone requirement and wont allow 5 alpha reductase to go online fully. Thus you need to create an environment when both progesterone and cortisol ARE NOT NEEDED. only this will put 5 alpha reductase back online.<br/>
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Taking cortisol tanks immune system. And increases 5 alpha reducates 2. since it is needed to break down cortisol and progesterone into it metabolites.<br/>
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taking high dose progesterone or dexamethasone at the same time would force the body to upregulate 5 alpha reductase 2.<br/>
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But it is much easier to do the same with mineral route which I outlined<br/>
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Copper keep thyroid low, while you increase potassium. This will allow both cortisol and progesterone to come down. And this will allow upregulation of 5 alpha reducate 2<br/>
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Bottom line. Finasteride blocks 5 alpha reductase 2. this happens since finasterid is progestine which effects both cortisol and progesterone. this causes the unsolvable alkalotic discrepancy between cortisol and progesterone.<br/>
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Cortisol lowers potassium in the cell, progesterone increases potassium in the cell. HERE you have both high progesterone and high cortisol . And cortisol cant come down, since progesterone is retaining the potassium. And progesterone cant come down, since 5 alpha reductase 2 is down. 5 alpha reductase 2 cant go back up, since cortisol is needed, since potassium is sky high in the cell, because of alkalosis.<br/>
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You see the mechanism here. <br/>
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To break this mechanism. you need to create an environment when both cortisol and progesterone are satisfied.<br/>
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Progesterone is satisfied by potassium. Cortisol is satisfied by lower metabolism( copper) Mangesium gets rid of sodium retention which cortisol caused. B2 lowers serotonin<br/>
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INSULIN will go up , only when progesterone COMES DOWN. Since high progesterone signal the body potassium deficiency, and in potassium deficiency insulin secretion will be ZERO. Since insulin puts potassium in the CELL.<br/>
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PROGESTERONE causes INSULIN TO BE ZERO and actually causes FRANK DIABETES.<br/>
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<URL url="http://www.pnas.org/content/99/24/15644.full">http://www.pnas.org/content/99/24/15644.full</URL> <br/>
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RU486 reverses this.<br/>
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But progesterone is raised in the body when potassium is deficient. Thus you better off take the mineral route that I outlined
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