PFS and immune connection

[Shadow]

....why?

Why? Because we are here to cure PFS and you are negating one of the most basic basic about the 5ar2 enzyme? You need more reasons?

Hold on, so WHY do you THINK that neurosteroid levels in the brain and the CSF are FUCKED UP on the drug and sometimes AFTER it?

He doesnt "think", Melcangi found it. http://www.pfsfoundation.org/tag/roberto-cosimo-melcangi/

 

[BeLikeWater]

Why? Because we are here to cure PFS and you are negating one of the most basic basic about the 5ar2 enzyme? You need more reasons?

Hold on, so WHY do you THINK that neurosteroid levels in the brain and the CSF are FUCKED UP on the drug and sometimes AFTER it?

He doesnt "think", Melcangi found it. http://www.pfsfoundation.org/tag/roberto-cosimo-melcangi/

That study refers to CNS not brain. There is plenty of 5ar2 in Spinal.

 

[Shadow]

Hold on, so WHY do you THINK that neurosteroid levels in the brain and the CSF are FUCKED UP on the drug and sometimes AFTER it?

He doesnt "think", Melcangi found it. http://www.pfsfoundation.org/tag/roberto-cosimo-melcangi/

That study refers to CNS not brain. There is plenty of 5ar2 in Spinal.

CNS is brain AND spinal cord

 

[TubZy]

Re: PFS and inmune connection

<r><QUOTE author="gbolduev" post_id="4504" time="1510961889" user_id="90"><s>

</s>
<QUOTE author="BeLikeWater" post_id="4502" time="1510961182" user_id="112"><s>

</s>
5ar2 and 5ar1 have different functions, the only one present in the brain is 5ar1 and seem to be opposed by T/DHT in blood, while 5ar2 ( sebaceous glands, prostate ) seems to be activated more by T/DHT in blood pointing to an inverse mechanism related to androgens. You definetly should check that out. Melcangi Pointed that we had very low neurosteroids that comes from 5ar1 in CNS. 5ar2 has no functions on brain.
<e>

</e></QUOTE>
<br/>
5 alpha R2 is what controls glucocorticoids.<br/>
<br/>
This is why when you feed glucocorticoids the expression of this enzyme goes up. This is how finasteride screws everything over by effecting cortisol and progesterone.<br/>
<br/>
I just took finasteride huge dosages 3 weeks ago. and had a huge crash. And today I am back to normal already.<br/>
<br/>
Here is what I am taking. Put some accent on copper and magnesium at the start to lower potassium levels.<br/>
<br/>
I am taking 3000 potassium chloride, (1/8 th of tea spoon)<br/>
magnesium gluconate 500-700<br/>
copper 4-6mg<br/>
zinc 30mg<br/>
taurine 2g<br/>
b2 -100<br/>
boron 2<br/>
calcium 200 <br/>
Also I take ACE( acezatolmide) here and there 250mg<br/>
Also I added tons of spinach to this protocol<br/>
<br/>
after a week<br/>
once a week thorne extra<br/>
and iron with manganese
<e>

</e></QUOTE>

What is the boron for again?</r>

 

[TubZy]

This also might sound dumb, but what about high dose progesterone and hydrocortisone? wouldn't that essentially downregulate both progesterone and cortisol at the same time? [mention]gbolduev[/mention]

 

[Helen]

This also might sound dumb, but what about high dose progesterone and hydrocortisone? wouldn't that essentially downregulate both progesterone and cortisol at the same time? @gbolduev

Posted that before. High dose progesterone, dexamethasone

 

[TubZy]

For some reason, I thought it had to be dexamethasone only as HC is way easier to get here and it is OTC here at least topically (or even prednisone). That makes much more sense now...

 

[TubZy]

[mention]Scenes[/mention]

 

[BeLikeWater]

For some reason, I thought it had to be dexamethasone only as HC is way easier to get here and it is OTC here at least topically (or even prednisone). That makes much more sense now...

People have been reporting curing themselves with both progesterone and HC, prednisone, etc... maybe we are in the good path! I will fund Gboldv with 10k$ if Im cured this year

 

[BeLikeWater]

Posted that before. High dose progesterone, dexamethasone

But didnt we were trying to upregulate cortisol activity? How can downregulate cortisol receptors do that?

 

[EsQimo]

Re: PFS and inmune connection

<t>In any case. I tested most of it, so I guess I can post here. Fin acts a progestin as we assumed correctly. Now the crash from fin and not ability to snap back is because there is a conflict between progesterone and cortisol created by fin. Basically after you get off fin, you have high progesterone and high cortisol and lowered 5 alpha reductase 2. Cortisol gets metabolized by 5 alpha reductase 2 , progesterone also. So you get stuck with high progesterone and high cortisol after fin. It should never be the case. Since progesterone should go high , cortisol low, cortisol high progesterone low. Since they regulate potassium in the cell.<br/>
<br/>
<br/>
In any case. when you take FIN it does indirectly inhibit 5 alpha reductase 2 by acting on progesterone and cortisol receptors.<br/>
<br/>
After you quit fin. You have high progesterone and high cortisol. And low acitivity of 5 alpha reductase 2. The reason why it does not snap back, since progesterone keeps retaining potassium and potassium stays high in the cell. Cortisol is keeping retaining sodium and causing alkalosis which puts potassium even higher in the cell and this puts a huge pressure on cortisol.<br/>
<br/>
5 alpha reductase 2 is what lowers cortisol. And it cant snap back, since cortisol is needed greatly at the moment.<br/>
<br/>
So the body is stuck. It cant increase 5 alpha reductase 2. And thus cortisol goes to cortisone excessively. This lowers insulin secretion to very low since cortisone lowers insulin in the body. And you are diabetic. <br/>
<br/>
So this is the my case. I am a case with low insulin. Fin has made be diabetic. <br/>
<br/>
Zinc is lost in the urine like crazy now. and iron stays in the liver. Since body thinks I have tons of progesterone and tons of cortisol. DHEA grows since zinc is going away.<br/>
<br/>
<br/>
So now I will break this loop by tanking potassium in the cell. tanking sodium in the cell. And forcing cortisol up by blocking <br/>
cortisol to cortisone converison, which will increase my insulin back to normal. Without insulin back to normal, All my attempts to increase zinc will be met with castration since zinc will increases progesterone which will retain more potassium which will increase metabolism and puts more pressure on cortisol which will lower 5 alpha reductase even lower. since 5 alpha reductase metabolizes cortisol.<br/>
<br/>
In this case , I will make my body have low potassium in the cell, and create increased cortisol( since I will stop cortisone conversion). Since increased cortisol should never exist with low cell potassium, body will have no other way to proceed but to upregulate 5 alpha reductase 2 to fight fatty liver and convert excessive cortisol . And I will get fixed from all these effects. Basically I will lower potassium, block cortisone , and force body to upregulate 5 alpha reductase 2</t>

What exactly is considered like high Progesteron?

I was roaming the forum searching for a connection between Cortisol and Progesteron.

This increase in Cortisol was the cause for my Progesteron to drop?
I have to increase my Cortisol for feeling good?
How exactly can i block the conversion of cortisol to cortisone as I am tanking potassium and sodium?

 

[expendable]

What exactly is considered like high Progesteron?

I was roaming the forum searching for a connection between Cortisol and Progesteron.

This increase in Cortisol was the cause for my Progesteron to drop?
I have to increase my Cortisol for feeling good?
How exactly can i block the conversion of cortisol to cortisone as I am tanking potassium and sodium?

I believe it was licorice root. Blocks cortisol -> cortisone pathway (inhibts the enzyme, can't remember which), increasing cortisol while decreasing cortisone.

 

[EsQimo]

I believe it was licorice root. Blocks cortisol -> cortisone pathway (inhibts the enzyme, can't remember which), increasing cortisol while decreasing cortisone.

Yes you are right.
It can be done by blocking 11β-HSD enzyme.
And licorice root can block it.

But Cortisol can take another pathway.
If 11β-HSD is blocked and 5αR2 is not working, it can brek down to its metabolites by 5βReductase.

Figure 1 from 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis. - Semantic Scholar