PFS and Post SSRI

[freeflow]

How that? Autophagy (Dr.Eric Berg)?

For my case its probably copper coming back to be bioavailable again and it makes my dopamine come back. And hgh cortisol switches on 5ar enzymes and my personality is recovering while fasting too, motivation.
I did 13 day water last summer but results slowly faded away. This summer i plan at least 20.

 

[barbaar]

@barbaar You need to do couple more cycles of ARL , if not good, then contact me and we will try to deal with PSSD directly thru skype. if succesful then others can repeat what you did.

Roger that, I'll keep my log updated

 

[Shadow]

No one is focused on DHT and no one even talks about DHT here.

I know, Im talking about people on other forums. But this acetylcholine thing is very interesting!! Thank you

@MNK99 your "craziness" and maniac effects wasnt related to post ssri I think. If you become maniac while on SSRI theres something else there, I have 2 friends who were misdiagnosed and they took SSRI and became maniac with other weird behavior, turned ou that one of them is bipolar(ssris are known to cause mania in them) and the other one I cant remember what he had. but was something were ssris arent recommended. Maybe you ADHD played a role.

Visit SA forum or PSSDForum, no one there is maniac, but suicidal, with ruminations, running thoughts, anehdonia, not to mention the physical symptoms.

 

[Jaxx]

@Shadow I know you are in a bad position and you dont try many things. But unless you test everything you wont know what to take. Or you need to experiment.

Basically if you want to increase serotonin sensitivity you need to block acetylcholine. It is parasympathetic systems, so they go back and forth.

Forskolin increases break down of acetylcholine. But on the snap back it will have you with even higher acetylcholine.

Atropine blocks acetylcholine and on the snap back it will have lower acetylcholine and higher serotonin action.

I like the theory of how acetylcholine is involved. I do wonder if the 2 cases also mean an opposite approach. I have seen people being cured by cycling something they felt bad on, but felt great during the off-cycle days. But also (perhaps even more) cases where people felt great taking something (like progesterone), but also got cured.

Looking at the symptoms, i seem to fall in the low acetylcholine group, but i feel great on progesterone. Trial and error might be the best way forward

 

[MNK99]

True true @Shadow, as we discussed.
I didn't just mean pssd of course ADHD/BPII played a role. BUT* I also had 99's while skipping school for exams, whereas after effexor I was on academic probation, and didn't know the day of the week. I didn't even smoke weed, after, all my friends were "sketchy" - clearly it did something to me. --NOT just pssd. AND with or without my dual diagnosis --- IT probably made it worse. It probably worsened both conditions. And I hope fin didn't too.

What kind of luck is that?
Misdiagnosis, blackouts, ADHD, BPII, PFS, hair loss, and worse. That's fucking crazy.

But yes... No one with bipolar should take these antidepressants but at 19-20 they're all misdiagnosed. Literally the average is beyond ten years for proper diagnosis.
-the old treatment model (before my time perhaps or in my early days), was a mood stabilizer + an antidepressant, now it's just a mood stabilizer and ADJUNCT meds if need be. 2-3 rather than like 5-10 or whatever some people are on. I'm on just one for ADHD. And if I didn't care about money, success, and all that bs, zero.
-Stimulants make me happier, but I have a love/hate relnship sort of.

I'd like to short sell that bitch's entire portfolio, become manager of their teaching hospital, and fire everyone.

 

[Area-1255]

@Shadow I know you are in a bad position and you dont try many things. But unless you test everything you wont know what to take. Or you need to experiment.

Basically if you want to increase serotonin sensitivity you need to block acetylcholine. It is parasympathetic systems, so they go back and forth.

Forskolin increases break down of acetylcholine. But on the snap back it will have you with even higher acetylcholine.

Atropine blocks acetylcholine and on the snap back it will have lower acetylcholine and higher serotonin action.

There's no "compensatory" responses that I know of with regard to Forskolin.
There's no increased or "higher" Acetylcholine because of more breakdown (by AChE) but there might be *slightly* more sensitive receptors (possibly).
Serotonin can UP or DECREASE Parasympathetic Activity; it depends on which Receptor. The autoreceptors tend to decrease it, mainly 5-HT1A.
5-HT1A inhibits NMDA, boosts Acetylcholine, inhibits AMPA, inhibits Glutamate etc - thus by both "autoreceptors" (decreasing serotonin) and by "heteroreceptors" inhibiting others - it would shift the CNS into a PARASYMPATHETIC NERVOUS SYSTEM DOMINANCE.

 

[Helen]

There's no "compensatory" responses that I know of with regard to Forskolin.
There's no increased or "higher" Acetylcholine because of more breakdown (by AChE) but there might be *slightly* more sensitive receptors (possibly).
Serotonin can UP or DECREASE Parasympathetic Activity; it depends on which Receptor. The autoreceptors tend to decrease it, mainly 5-HT1A.
5-HT1A inhibits NMDA, boosts Acetylcholine, inhibits AMPA, inhibits Glutamate etc - thus by both "autoreceptors" (decreasing serotonin) and by "heteroreceptors" inhibiting others - it would shift the CNS into a PARASYMPATHETIC NERVOUS SYSTEM DOMINANCE.

If you use forskolin to lower acetylcholine, when you stop you get much worse than before. there is a snap back. transcriptional inducers and their upregulation of acetylcholinesterase does not last. Your acetylcholine action will be more since receptors will be more sensitive. Forskolin was tried for this many times and it fails for this cause.( IMO should never be used)

5 ht1A decreases acetylcholine. acetylcholine can be used for sympathetic and parasympathetic system. 5 ht1A decreases acetylcholine in certain parts of the brain , this is why 5ht1a decreases memory. The role of 5-HT1A receptors in learning and memory - ScienceDirect

In any case this all has nothing to do with all of this anyway, there are no mistakes made by the body. Glutathione recylcing has to be returned this will increases sugar metabolism , this will increase vitamin C recycling , this will increases noradrenaline , body will use fats . and this will allow acetylcholine to come down on its own.
This is how forskolin works, only forskolin should not be used, instead B vitamins should be used along with vitamin C, and may be some copper and histidine.


the goal in all these imbalances is tostart up sugar metabolism , and use fats at the same time. NADPH is impaired so bile acids are gone. and gone for a long time. Without them there is no lipids. Body has to use protein for energy. this raises and keep cortisol high, fats cant be used since noradrenaline is not allowed, since that will decrease Co2. Once you increase b1 and b vitamins, this will increase glutathione recylcing, and increase vitamin C. and increase noradrenaline. vitamin C with NADPH converts cholestrol into bile acids, within couple of weeks if you eat good fats , you will retain lipids. And now your body will run on sugar and lipids at the same time. This will increase stress response.

Cortisol will come down, ammonia will be down. Acetylcholine will have to go down since it is not needed anymore.

Body is not stuck in parasympathetic , it chose to do it on purpose.

 

[Helen]

@Area-1255 ARL understands all of these imbalances and mostly gives the correct things for all the body chemistries. Sometimes they do have problems with dosages. And detox reaction.

Also the major problem could be that lipids wont be absorbed fast enough to substitute for cortisol. this happens since bile was stagnant for so long without vitamin C and NADPH , there were no bile acids, and all that biluribin and cholesterol are just stuck as a huge mess in the gallbladder, this is why I highly recommend the liver flushes for anyone with PFS PSSD or any other disorders.

In electrolytes protocol all of it has been written out for months. but not many people do this unfortunately.

 

[freeflow]

If you use forskolin to lower acetylcholine, when you stop you get much worse than before. there is a snap back. transcriptional inducers and their upregulation of acetylcholinesterase does not last. Your acetylcholine action will be more since receptors will be more sensitive. Forskolin was tried for this many times and it fails for this cause.( IMO should never be used)

5 ht1A decreases acetylcholine. acetylcholine can be used for sympathetic and parasympathetic system. 5 ht1A decreases acetylcholine in certain parts of the brain , this is why 5ht1a decreases memory. The role of 5-HT1A receptors in learning and memory - ScienceDirect

In any case this all has nothing to do with all of this anyway, there are no mistakes made by the body. Glutathione recylcing has to be returned this will increases sugar metabolism , this will increase vitamin C recycling , this will increases noradrenaline , body will use fats . and this will allow acetylcholine to come down on its own.
This is how forskolin works, only forskolin should not be used, instead B vitamins should be used along with vitamin C, and may be some copper and histidine.


the goal in all these imbalances is tostart up sugar metabolism , and use fats at the same time. NADPH is impaired so bile acids are gone. and gone for a long time. Without them there is no lipids. Body has to use protein for energy. this raises and keep cortisol high, fats cant be used since noradrenaline is not allowed, since that will decrease Co2. Once you increase b1 and b vitamins, this will increase glutathione recylcing, and increase vitamin C. and increase noradrenaline. vitamin C with NADPH converts cholestrol into bile acids, within couple of weeks if you eat good fats , you will retain lipids. And now your body will run on sugar and lipids at the same time. This will increase stress response.

Cortisol will come down, ammonia will be down. Acetylcholine will have to go down since it is not needed anymore.

Body is not stuck in parasympathetic , it chose to do it on purpose.

I feel like im in this, arl wrote me im in parasymphathetic state. I can arely put on some muscle, no matter how much protein im eating and working out very hard.

 

[Kiwiii]

I Think @Helen is right. When I was young I had cholinergic chocs when I was bathing in too hot water.

But why would ACE higher CO2 it is a diuretic known to lower CO2