PFS possible reason.

[Helen]

Guys, if you look at Melcangi study and Wuf's blood tests and CSF values. You will clearly see, that DHT is zero in CSF. It is very low and testosterone is high in CSF

Testosterone is not being converted into DHT in the brain. It is very clear. And since testosterone is already high there body wants to bind stuff with SHBG
You can see it here, that SHBG controls the entrace of testosterone into CSF The effects of sex hormone binding globulin (SHBG) on testosterone transport into the cerebrospinal fluid. - PubMed - NCBI

So this tells you that 5AR is not working in the brain. Possible since the body does not want to convert testosterone into DHT.


Now if you look further into that study. and Wuf's tests. You will see that progesterone and pregnenolone are also super low in CSF.

Why? The only way how they could be low is if they are bound by CBG( transcortin ) in blood. and transcortin binds cortisol also mainly


Now follow me. if progesterone is low in CSF , then how would testosterone convert into DHT in the brain. 5AR reductase will be prohibited, since 5AR will convert progesterone further down into its metabolites, but it is already low.

This is your fork.

And I think this might have happened, since androgen deprivation caused GR overexpression, and AR overexpression.

And then when you quit the drug, both CBG( transortin ) and SHBG go up . trying not to let DHT and Cortisol into the brain. and by doing this. They bind other hormones also, like estro and progesterone.

And binding of progesterone stops even remote possibility of downregulation of AR since 5AR will never go up.

 

[Helen]

This explains recoveries from progesterone, this explains recoveries from tribulus, this explains recoveries from cortisol supplements,

this explains feeling totally cured on RU, since it blocks AR and GR which lowers SHBG and CBG

 

[Helen]

We should try to test CBG( transcortin ) and match it with bloods.

@talkingant

 

[barbaar]

We should try to test CBG( transcortin ) and match it with bloods.

@talkingant

I'll try to get this done next week too

 

[RebelWithACause]

WTF is this PSSD or PFS?

 

[Pescagrullas]

Guys, if you look at Melcangi study and Wuf's blood tests and CSF values. You will clearly see, that DHT is zero in CSF. It is very low and testosterone is high in CSF

Testosterone is not being converted into DHT in the brain. It is very clear. And since testosterone is already high there body wants to bind stuff with SHBG
You can see it here, that SHBG controls the entrace of testosterone into CSF The effects of sex hormone binding globulin (SHBG) on testosterone transport into the cerebrospinal fluid. - PubMed - NCBI

So this tells you that 5AR is not working in the brain. Possible since the body does not want to convert testosterone into DHT.


Now if you look further into that study. and Wuf's tests. You will see that progesterone and pregnenolone are also super low in CSF.

Why? The only way how they could be low is if they are bound by CBG( transcortin ) in blood. and transcortin binds cortisol also mainly


Now follow me. if progesterone is low in CSF , then how would testosterone convert into DHT in the brain. 5AR reductase will be prohibited, since 5AR will convert progesterone further down into its metabolites, but it is already low.

This is your fork.

And I think this might have happened, since androgen deprivation caused GR overexpression, and AR overexpression.

And then when you quit the drug, both CBG( transortin ) and SHBG go up . trying not to let DHT and Cortisol into the brain. and by doing this. They bind other hormones also, like estro and progesterone.

And binding of progesterone stops even remote possibility of downregulation of AR since 5AR will never go up.

No doubt that i get better with R-Andro or ella, can you recomend me a supplement for cortisol? maybe Ashawanda? i have a very crap skin (wrinkles ,stretch marks, dryness) due to cortisol probbaly so i want to try..it
thanks mate

 

[ruprmurdoch]

WTF is this PSSD or PFS?

pfs-post fiinasteride syndrome
pssd- post ssri sexual dysfunction

 

[freeflow]

Helen just realized what wuf was saying that DHT is 0 in the brain, and not because it is in its little home
Nice topic btw, simple yet most probable explanation.

Coffee increases brain progesterone as well, occasionally it gives me a very good personality boost.

 

[BC2018]

This explains recoveries from progesterone, this explains recoveries from tribulus, this explains recoveries from cortisol supplements,

I know for a fact that's a lie, Mew on Propeciahelp emphatically told me Tribulus doesn't work.

 

[RebelWithACause]

pfs-post fiinasteride syndrome
pssd- post ssri sexual dysfunction

I mean people from PSSD are testing stuff for a PFS theory. It made no sense to me.

 

[Helen]

I mean people from PSSD are testing stuff for a PFS theory. It made no sense to me.

I posted at least 3 studies where it says that SSRI upregulates GR receptor. so it could be the same. as I posted at least 2 studies yesterday that androgen deprivation upregulates GR receptor

 

[RebelWithACause]

I posted at least 3 studies where it says that SSRI upregulates GR receptor. so it could be the same. as I posted at least 2 studies yesterday that androgen deprivation upregulates GR receptor

Ah ok my bad

 

[ruprmurdoch]

I mean people from PSSD are testing stuff for a PFS theory. It made no sense to me.

you can mess your body only in two main pathologies, or too high prolactine, or too high cortisol. it's a big shortcut, beacuse they may be subgroups. but no matter what you take, in my observation you can fuck up yourself in two main ways.

 

[ruprmurdoch]

in my observation its mushroms vs bacteria
almost all time bacteria was winning, but now mushroms are.
mushroms-cortisol
prolactin-bacteria
till 1900's what soups people eat ? fermented aka beer aka yeasts soup. Beacuse we were full of bacterias. We had very low tension, and we want to raise it.
Now everybody eat too much sugar, and this is what dont like bacterias, and yeasts like. We have hypertension.
Of course I will say like Helen -90 % have to much yeasts, and 10 % too much bacterias. But last few thousand years it was opposite.

I think main cure or stilt is take opposite. If you have yeasts problem, take bacterias . If you have bacterias problem, take yeasts.

 

[Reverse]

in my observation its mushroms vs bacteria
almost all time bacteria was winning, but now mushroms are.
mushroms-cortisol
prolactin-bacteria
till 1900's what soups people eat ? fermented aka beer aka yeasts soup. Beacuse we were full of bacterias. We had very low tension, and we want to raise it.
Now everybody eat too much sugar, and this is what dont like bacterias, and yeasts like. We have hypertension.
Of course I will say like Helen -90 % have to much yeasts, and 10 % too much bacterias. But last few thousand years it was opposite.

I think main cure or stilt is take opposite. If you have yeasts problem, take bacterias . If you have bacterias problem, take yeasts.

My first few months of total crash was a lot of strange and odd gastric noises and movement along with rumbling. Something was rewired in my gut/digestive system.

Maybe it's not a candida or whatever for all of us but most likely the gut flora was altered along with organ linings.

There's a lot of "recalibration" needed to get out of this.

We need to fix all three brains...

 

[Helen]

in my observation its mushroms vs bacteria
almost all time bacteria was winning, but now mushroms are.
mushroms-cortisol
prolactin-bacteria
till 1900's what soups people eat ? fermented aka beer aka yeasts soup. Beacuse we were full of bacterias. We had very low tension, and we want to raise it.
Now everybody eat too much sugar, and this is what dont like bacterias, and yeasts like. We have hypertension.
Of course I will say like Helen -90 % have to much yeasts, and 10 % too much bacterias. But last few thousand years it was opposite.

I think main cure or stilt is take opposite. If you have yeasts problem, take bacterias . If you have bacterias problem, take yeasts.

it is serotonin , acetylcholine balance.


like if you have low serotonin and high acetylcholine, you will be helped by acetaldehyde things. like old cheeses with mold, mayo. etc

if you have higher serotonin and lower acetylcholine, probiotics.


But all of this caused not by bacteria.

high acetylcholine is caused by aluminum which inhibits acetylcholinesterase.

high serotonin is caused by mercury lead. by killing cysteine to detox them. and thus inhibiting ALDH enzyme, and killing break down of histamine and serotonin and all amines.


soon people will need to constantly live on chelators , too much of stuff going in.

 

[Nina]

it is serotonin , acetylcholine balance.


like if you have low serotonin and high acetylcholine, you will be helped by acetaldehyde things. like old cheeses with mold, mayo. etc

if you have higher serotonin and lower acetylcholine, probiotics.


But all of this caused not by bacteria.

high acetylcholine is caused by aluminum which inhibits acetylcholinesterase.

high serotonin is caused by mercury lead. by killing cysteine to detox them. and thus inhibiting ALDH enzyme, and killing break down of histamine and serotonin and all amines.


soon people will need to constantly live on chelators , too much of stuff going in.

Also progesterone inhibits it or something no? It blocks acetylcholine and then makes it go too high when progesterone finally goes down

 

[ruprmurdoch]

it is serotonin , acetylcholine balance.


like if you have low serotonin and high acetylcholine, you will be helped by acetaldehyde things. like old cheeses with mold, mayo. etc

if you have higher serotonin and lower acetylcholine, probiotics.


But all of this caused not by bacteria.

high acetylcholine is caused by aluminum which inhibits acetylcholinesterase.

high serotonin is caused by mercury lead. by killing cysteine to detox them. and thus inhibiting ALDH enzyme, and killing break down of histamine and serotonin and all amines.


soon people will need to constantly live on chelators , too much of stuff going in.

Great point. There is new player in the game. Al and Hg. But, In my observation Hg raise prolactin, so its cooperating with bacterias. And Al is cooperating with yeasts beacuse it raise cortisol. But I may be wrong please checki it on your own.

 

[RebelWithACause]

it is serotonin , acetylcholine balance.


like if you have low serotonin and high acetylcholine, you will be helped by acetaldehyde things. like old cheeses with mold, mayo. etc

if you have higher serotonin and lower acetylcholine, probiotics.


But all of this caused not by bacteria.

high acetylcholine is caused by aluminum which inhibits acetylcholinesterase.

high serotonin is caused by mercury lead. by killing cysteine to detox them. and thus inhibiting ALDH enzyme, and killing break down of histamine and serotonin and all amines.


soon people will need to constantly live on chelators , too much of stuff going in.

Maybe chemtrails are real. Plus vaccines.

 

[Helen]

Aluminium actually increases acetylcholinestrase that metabolises acetylcholine, thereby reducing acetylcholine's concentration.

Protective effects of copper against aluminum toxicity on acetylcholinesterase and catecholamine contents of different regions of rat’s brain


there is so much confusing info on this topic.

ALS is caused by aluminum and treated with L serine.

L serine increases acetylcholinsterase